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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
farnesyl pyrophosphate synthase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "farnesyl pyrophosphate synthase" in MCE Product Catalog:
4
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Research Areas:
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
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Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium Monohydrate can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium Monohydrate inhibits tumor cell proliferation (such as ER + breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium Monohydrate is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
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1 Cited Publications
Cat. No.: HY-B0515B
CAS No.: 138844-81-2
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Ibandronate Sodium is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium inhibits tumor cell proliferation (such as ER+ breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
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Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC50 of 3 nM, and also an antagonist of P2X2/3 receptors with an IC50 of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer .
1
1 Cited Publications
Cat. No.: HY-W585869
CAS No.: 92692-39-2
Target:
Category:
Natural Products Plants Eupatorium buniifolium Hook. & Arn. Cytokinin Agricultural Research Umbelliferae Phytohormone Disease Research Fields Inflammation/Immunology Cancer
Target:
Cat. No.: HY-P75196
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FDPS; FPP synthase; farnesyl Diphosphate synthase; FPS; (2E,6E)-farnesyl Diphosphate synthase; Alternative Protein FDPS; farnesyl pyrophosphate synthase; FPP Synthetase; farnesyl pyrophosphate Synthetase, Dimethylallyltranstransferase, Geranyltranstransfe
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P75197
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FDPS; FPP synthase; farnesyl Diphosphate synthase; FPS; (2E,6E)-farnesyl Diphosphate synthase; Alternative Protein FDPS; farnesyl pyrophosphate synthase; FPP Synthetase; farnesyl pyrophosphate Synthetase, Dimethylallyltranstransferase, Geranyltranstransfe
Species:
Human
Source:
E. coli
Cat. No.: HY-176855
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Research Areas:
RAM1147 is a farnesyl pyrophosphate synthase (FPPS) inhibitor. RAM1147 disrupts protein isoprenylation, inhibiting tumor cell proliferation. RAM1147 is promising for research of cancers (e.g., myeloma, breast cancer) and bone metabolism disorders (e.g., osteoporosis) .
Cat. No.: HY-117012
CAS No.: 105462-23-5
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NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme .
Cat. No.: HY-B0515R
CAS No.: 138926-19-9
Synonyms: BM-210955 (Standard); RPR-102289A (Standard)
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Research Areas:
Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) (Standard) is the analytical standard of Ibandronate Sodium Monohydrate (HY-B0515). This product is intended for research and analytical applications. Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium Monohydrate can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium Monohydrate inhibits tumor cell proliferation (such as ER + breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium Monohydrate is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
Cat. No.: HY-182516
CAS No.: 32545-60-1
Target:
Aminobutane bisphosphonate is a Trypanosoma cruzi farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC50 of 30.77 μM against Trypanosoma cruzi. Aminobutane bisphosphonate inhibits proliferation of intracellular amastigote Trypanosoma cruzi and lacks activity against non-infective epimastigote forms. Aminobutane bisphosphonate reduces osteoclastic bone resorption, osteoid surface extent, and osteoclast number per mm of bone surface. Aminobutane bisphosphonate can be used for the research of american trypanosomiasis (chagas' disease) and immobilization-related bone loss .
Cat. No.: HY-P70224
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GGPS1; GGPPS1; Geranylgeranyl Diphosphate synthase 1; Geranylgeranyl Diphosphate synthase; Geranylgeranyl pyrophosphate synthase; GGPP synthase; (2E,6E)-farnesyl Diphosphate synthase; GGPPSase; Dimethylallyltranstransferase; MUDHLOV; farnesyl Diphosphate
Species:
Human
Source:
E. coli
Cat. No.: HY-P702577
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GGPS1; GGPPS1; Geranylgeranyl Diphosphate synthase 1; Geranylgeranyl Diphosphate synthase; Geranylgeranyl pyrophosphate synthase; GGPP synthase; (2E,6E)-farnesyl Diphosphate synthase; GGPPSase; Dimethylallyltranstransferase; MUDHLOV; farnesyl Diphosphate
Species:
Human
Source:
HEK293
Cat. No.: HY-W100829
CAS No.: 51527-19-6
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Research Areas:
FPPS ligand 3 (compound 2) is a farnesyl pyrophosphate synthase (FPPS) ligand. FPPS ligand 3 binds to the hydrophobic base region of the FPPS pocket. FPPS ligand 3 can be used to design and synthesize FPPS inhibitors .
Cat. No.: HY-165186
CAS No.: 104261-69-0
Synonyms: NE-58051
Homorisedronate (NE-58051) is a MMP inhibitor with high bone mineral affinity but low bone antiresorptive activity in vivo. Homorisedronate inhibits the proteolytic activity of MMP-2, MMP-9, and MMP-12 through zinc chelation and phosphonate groups, with IC50 values of 40 μM, 160 μM, and 80 μM for human MMP-2, mouse MMP-9, and rabbit MMP-12, respectively. Homorisedronate inhibits breast cancer and melanoma cell proliferation without inducing MRONJ-like lesions, altering osteoclast activity, or changing serum TRAcP-5b levels. Homorisedronate is suitable for research related to breast cancer and melanoma .
Cat. No.: HY-16108
CAS No.: 157126-18-6
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BMS-187745 is a squalene synthase inhibitor. BMS-187745 reduces cholesterol synthesis. BMS-187745 does not induce significant myotoxicity in skeletal muscle .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
