13 Results for "

free sulfhydryl groups

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "free sulfhydryl groups" in MCE Product Catalog:

mPEG5000-Mal
mPEG5000-Mal
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Cat. No.: HY-W020780
CAS No.: 724722-89-8
Synonyms: mPEG5000-Maleimide
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .
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N-Ethylmaleimide-d5
N-Ethylmaleimide-d5
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Cat. No.: HY-D0843S
CAS No.: 360768-37-2
Synonyms: NEM-d5
N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor . N-ethylmaleimide specific inhibits phosphate transport in mitochondria . N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor .
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4-Arm PEG-SH (MW 10000)
4-Arm PEG-SH (MW 10000)
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Cat. No.: HY-W1048849B
Synonyms: 4-Arm PEG-thiol (MW 10000)
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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4-Arm PEG5000-SH
4-Arm PEG5000-SH
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Cat. No.: HY-W1048849A
Synonyms: 4-Arm PEG5000-thiol
4-Arm PEG5000-SH (4-Arm PEG5000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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4-Arm PEG20000-SH
4-Arm PEG20000-SH
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Cat. No.: HY-W1048849C
Synonyms: 4-Arm PEG20000-thiol
4-Arm PEG20000-SH (4-Arm PEG20000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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800CW maleimide
800CW maleimide
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Cat. No.: HY-D1869
800CW maleimide is an infrared dye that can be used for labeling molecules that contain free sulfhydryl (–SH) groups (Ex: 778 nm; Em: 796 nm). 800CW maleimide binds to plasma proteins .
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Preactivated PE-Cy5 Maleimide
Preactivated PE-Cy5 Maleimide
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Cat. No.: HY-D2182
Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
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Preactivated APC-Cy5.5 Maleimide
Preactivated APC-Cy5.5 Maleimide
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Cat. No.: HY-D2180
Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
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4-Arm PEG40000-SH
4-Arm PEG40000-SH
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Cat. No.: HY-W1048849D
Synonyms: 4-Arm PEG40000-thiol
4-Arm PEG40000-SH (4-Arm PEG40000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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Senecionine acetate
Senecionine acetate
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Cat. No.: HY-N7594
CAS No.: 126642-77-1
Synonyms: O-Acetylsenecionine
Category:  

Alkaloids Erinacea anthyllis Link Pyrrole Alkaloids Other Diseases Plants Compositae Disease Research Fields

Target:  

Mitochondrial Metabolism

Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca 2+ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .
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PerCP Maleimide
PerCP Maleimide
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Cat. No.: HY-D2094
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
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Oxophenarsine hydrochloride
Oxophenarsine hydrochloride
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Cat. No.: HY-105789
CAS No.: 538-03-4
Target:  

HIV Bacterial

Research Areas:  

Infection Inflammation/Immunology

Oxophenarsine hydrochloride is an anti-syphilitic agent, and also has non-classical applications including treating chronic discoid lupus erythematosus, inhibiting HIV-1 protein synthesis, and prolonging the duration of insulin action . Oxophenarsine hydrochloride forms an unstable insulin complex via sulfhydryl groups or free amino groups, thereby prolonging the hypoglycemic effect of insulin. Oxophenarsine hydrochloride inhibits HIV-1-specific protein synthesis and virus production .
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2-Deacetyl-4-tigloylchamissionolide
2-Deacetyl-4-tigloylchamissionolide
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Cat. No.: HY-N19808
CAS No.: 173401-52-0
Category:  

Terpenoids Sesquiterpenes Plants Compositae

Target:  

Drug Derivative

2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .
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