Search Result

Results for "

free sulfhydryl groups

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (5) Cathepsin (1) Deubiquitinase (1) Drug Derivative (1) Fluorescent Dye (4) Mitochondrial Metabolism (1) TRP Channel (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W020780

mPEG5000-Mal mPEG5000-Maleimide	Biochemical Assay Reagents	Cancer
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .

HY-D0843S

N-Ethylmaleimide-d5 NEM-d₅	Cathepsin Deubiquitinase	Others
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor . N-ethylmaleimide specific inhibits phosphate transport in mitochondria . N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor .

HY-W1048849B

4-Arm PEG-SH (MW 10000) 4-Arm PEG-thiol (MW 10000)	Biochemical Assay Reagents	Others
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849A

4-Arm PEG5000-SH 4-Arm PEG5000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG5000-SH (4-Arm PEG5000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849C

4-Arm PEG20000-SH 4-Arm PEG20000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG20000-SH (4-Arm PEG20000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-D1869

800CW maleimide	Fluorescent Dye	Others
800CW maleimide is an infrared dye that can be used for labeling molecules that contain free sulfhydryl (–SH) groups (Ex: 778 nm; Em: 796 nm). 800CW maleimide binds to plasma proteins .

HY-D2182

Preactivated PE-Cy5 Maleimide	Fluorescent Dye	Others
Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-D2180

Preactivated APC-Cy5.5 Maleimide	Fluorescent Dye	Others
Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-W1048849D

4-Arm PEG40000-SH 4-Arm PEG40000-thiol	Biochemical Assay Reagents	Others
4-Arm PEG40000-SH (4-Arm PEG40000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-N7594

Senecionine acetate O-Acetylsenecionine	Mitochondrial Metabolism	Others
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca ²⁺ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .

HY-D2094

PerCP Maleimide	Fluorescent Dye	Inflammation/Immunology Cancer
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .

HY-N12639

β-Sanshool	TRP Channel	Others
β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness .

HY-N19808

2-Deacetyl-4-tigloylchamissionolide	Drug Derivative	Cancer
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .

Cat. No.	Product Name	Type

HY-D1869

800CW maleimide	Fluorescent Dyes
800CW maleimide is an infrared dye that can be used for labeling molecules that contain free sulfhydryl (–SH) groups (Ex: 778 nm; Em: 796 nm). 800CW maleimide binds to plasma proteins .

HY-D2182

Preactivated PE-Cy5 Maleimide	Fluorescent Dyes
Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-D2180

Preactivated APC-Cy5.5 Maleimide	Fluorescent Dyes
Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-D2094

PerCP Maleimide	Fluorescent Dyes
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .

Cat. No.	Product Name	Type

HY-W020780

mPEG5000-Mal mPEG5000-Maleimide	Biochemical Assay Reagents
mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .

mPEG5000-Mal

mPEG5000-Maleimide

Biochemical Assay Reagents

mPEG5000-Mal (mPEG5000-Maleimide) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG5000-Mal can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the protein's secondary structure; secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG5000-Mal can react with free cysteine in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG5000-Mal can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG5000-Mal can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses .

HY-W1048849B

4-Arm PEG-SH (MW 10000) 4-Arm PEG-thiol (MW 10000)	Biochemical Assay Reagents
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849A

4-Arm PEG5000-SH 4-Arm PEG5000-thiol	Biochemical Assay Reagents
4-Arm PEG5000-SH (4-Arm PEG5000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849C

4-Arm PEG20000-SH 4-Arm PEG20000-thiol	Biochemical Assay Reagents
4-Arm PEG20000-SH (4-Arm PEG20000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

HY-W1048849D

4-Arm PEG40000-SH 4-Arm PEG40000-thiol	Biochemical Assay Reagents
4-Arm PEG40000-SH (4-Arm PEG40000-thiol) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7594

Senecionine acetate O-Acetylsenecionine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Erinacea anthyllis Link Other Diseases Plants Compositae Disease Research Fields Source Classification	Mitochondrial Metabolism
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca ²⁺ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .

HY-N12639

β-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Natural Products Rutaceae Plants Source Classification	TRP Channel
β-Sanshool is found in Zanthoxylum bungeanum and has a unique pungent taste. β-Sanshool is a TRPV1 activator that activates TRPV1 to increase intracellular calcium concentration. β-Sanshool has antioxidant effects and enhances free radical scavenging activity. β-Sanshool increases the thermal denaturation temperature and stabilizes protein structures. β-Sanshool induces sensory experiences of numbness and bitterness .

HY-N19808

2-Deacetyl-4-tigloylchamissionolide	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Source Classification	Drug Derivative
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor . N-ethylmaleimide specific inhibits phosphate transport in mitochondria . N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

free sulfhydryl groups

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products