Oxophenarsine hydrochloride
Oxophenarsine hydrochloride is an anti-syphilitic agent, and also has non-classical applications including treating chronic discoid lupus erythematosus, inhibiting HIV-1 protein synthesis, and prolonging the duration of insulin action. Oxophenarsine hydrochloride forms an unstable insulin complex via sulfhydryl groups or free amino groups, thereby prolonging the hypoglycemic effect of insulin. Oxophenarsine hydrochloride inhibits HIV-1-specific protein synthesis and virus production.
For research use only. We do not sell to patients.
- CAS No.: 538-03-4
- Formula: C6H7AsClNO2
- Molecular Weight:235.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Oxophenarsine (18 h) hydrochloride forms an unstable complex with purified Lilly Isletin insulin, and this complex reverts to unmodified insulin after 2 weeks of storage at low temperature[1].
Oxophenarsine hydrochloride (0.15-12 μg/mL; 4-12 days) shows no cytotoxicity against H9 T cells and PHA-stimulated peripheral blood lymphocytes at concentrations up to 6.0 μg/mL, and toxicity is only observed at concentrations of 12 μg/mL and above[2].
Oxophenarsine hydrochloride (0.038-6.0 μg/mL; 12 days) potently suppresses acute HIV-1 infection in PHA-stimulated peripheral blood lymphocytes and H9 T cells. After 12 days of incubation, concentrations of 0.15 μg/mL and above achieve over 5 log10 inhibition[2].
Oxophenarsine hydrochloride (0.06-60 μg/mL) does not inhibit the activity of purified HIV-1 reverse transcriptase even at concentrations as high as 60 μg/mL[2].
Oxophenarsine hydrochloride (0.006-6.0 μg/mL; 4 weeks) completely inhibits HIV-1 production by lymphocytes from HIV-1 seropositive subjects that are co-cultured with PHA-stimulated peripheral blood lymphocytes for 4 weeks at concentrations of 0.6 μg/mL and above[2].
Oxophenarsine hydrochloride (0.6-6.0 μg/mL; 0-40 days) potently inhibits HIV-1 production in H9-HIV-1 persistently infected cells at concentrations of 0.6 μg/mL and above, eliminates detectable viral p24, reverse transcriptase activity and infectious virus within 4-7 days, and the inhibitory effect is reversible after drug withdrawal[2].
Oxophenarsine hydrochloride (0.6-6.0 μg/mL; 10 days) inhibits the synthesis of HIV-1-specific proteins in acutely infected H9 cells at concentrations of 0.6 μg/mL and higher, without affecting viral DNA or RNA levels[2].
Oxophenarsine hydrochloride (0.6-6.0 μg/mL; 20 days) inhibits the synthesis of HIV-1-specific proteins in H9-HIV-1 persistently infected cells at concentrations of 0.6 μg/mL and above, without affecting viral DNA or RNA levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 538-03-4
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Molecular Weight 235.50
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Formula C6H7AsClNO2
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SMILES
O=[As]C1=CC=C(C(N)=C1)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
LEONARD CS. Influence of oxophenarsine on hypoglycemic action of insulin. Proc Soc Exp Biol Med. 1948 Jan;67(1):89-92.
[Content Brief]
[2]. Gupta P, et al. Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes. AIDS research and human retroviruses. 1990 Dec;6(12):1417-23. [Content Brief]
[3].
HYMAN AB. Oxophenarsine hydrochloride in treatment of lupus erythematosus. Arch Derm Syphilol. 1946 Jan;53:26-30.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxophenarsine hydrochloride Related Classifications
HY-105789 Related Classifications
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