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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
germinal center kinase
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "germinal center kinase" in MCE Product Catalog:
2
2 Cited Publications
GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-Abl WT and Bcr-Abl T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies .
Synonyms: HMSL 10017-101-1
HG6-64-1 (HMSL 10017-101-1) is a B-raf kinase modulator.HG6-64-1 modulates B-raf kinase activity, including the V600E mutant form and the drug-resistant gatekeeper mutation T529I. HG6-64-1 is a germinal center kinase inhibitor. HG6-64-1 induces cell cycle arrest and apoptosis. HG6-64-1 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .
Cat. No.: HY-143868
CAS No.: 2268794-52-9
HPK1-IN-27 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-27 has the potential for the research of cancer diseases (extracted from patent WO2019016071A1, compound 38) .
Cat. No.: HY-143871
CAS No.: 2700292-56-2
HPK1-IN-30 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-30 has the potential for the research of cancer diseases (extracted from patent WO2021175271A1, compound 3) .
Cat. No.: HY-P703250
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAP4K3; MEK kinase kinase 3; Prev. RAB8IPL1; Mitogen-Activated Protein kinase kinase kinase kinase; GLK; Non-Specific Serine/Threonine Protein kinase; MAPKKKK3; germinal center kinase-Like kinase; germinal center kinase-Related Protein kinase; Uncharacter
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P810829
Synonyms: RAB8IPL1; Mitogen-activated protein kinase kinase kinase kinase 3; germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
Cat. No.: HY-P706071
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAP4K5; germinal center kinase-Related; Mitogen-Activated Protein kinase kinase kinase kinase 5; MEK kinase kinase 5; KHS; MEKKK 5; kinase Homologous To SPS1/STE20; Mitogen-Activated Protein kinase kinase kinase kinase; KHS1; Non-Specific Serine/Threonine
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-10943R
CAS No.: 839706-07-9
Target:
Research Areas:
GNF-7 (Standard) is the analytical standard of GNF-7 (HY-10943). This product is intended for research and analytical applications. GNF-7 is a multiKinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 Kinase 1) and GCK (germinal center Kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
