MAP4K3 Protein, Human (S170A, sf9, GST, Flag)
MAP4K3 Protein, Human (S170A, sf9, GST, Flag) is the recombinant human-derived MAP4K3, expressed by sf9 insect cells , with GST, Flag labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
MAP4K3 Protein, Human (S170A, sf9, GST, Flag) is the recombinant human-derived MAP4K3, expressed by sf9 insect cells , with GST, Flag labeled tag.
MAP4K3 is a serine/threonine kinase that plays a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway (by similar: PubMed:9275185). As an activator of the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, MAP4K3 acts in parallel to and is partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, establishing MAP4Ks as components of the expanded Hippo pathway (by similar: PubMed:26437443).
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST;Flag
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Accession
Q8IVH8-1 (M1-G380, S170A)
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Gene ID8491
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Protein Length
Partial
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Synonyms
MAP4K3; MEK Kinase Kinase 3; Prev. RAB8IPL1; Mitogen-Activated Protein Kinase Kinase Kinase Kinase; GLK; Non-Specific Serine/Threonine Protein Kinase; MAPKKKK3; Germinal Center Kinase-Like Kinase; Germinal Center Kinase-Related Protein Kinase; Uncharacter
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AA Sequence
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYG
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Predicted Molecular Mass
71 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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