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Results for "

hAKR1B1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aldose Reductase (1) Apoptosis (1) c-Myc (1) Endogenous Metabolite (1) GSK-3 (1) Mitochondrial Metabolism (1) Reactive Oxygen Species (ROS) (1) β-catenin (1)
By Research Areas:	Metabolic Disease (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Soyasaponin Ba 1 Publications Verification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc	Metabolic Disease
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

Sandosaponin A Soyasaponin Bd	Endogenous Metabolite	Others
Sandosaponin A (Soyasaponin Bd) is a saponin with inhibitory activity against human recombinant aldehyde reductase (hAKR1B1). Sandosaponin A can inhibit the reduction of l-idose and 4-hydroxynonenal to varying degrees. The presence of Sandosaponin A reveals the challenges posed by the masking effect of conventional aldehyde reductase inhibitors in mixtures when exploring differential aldehyde reductase inhibitors. The inhibitory mechanism of Sandosaponin A may be related to its mode of action on different substrates .

Soyasaponin Ba 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

Sandosaponin A Soyasaponin Bd	Triterpenes Leguminosae Terpenoids Plants Phaseolus vulgaris Linn. Source Classification	Endogenous Metabolite
Sandosaponin A (Soyasaponin Bd) is a saponin with inhibitory activity against human recombinant aldehyde reductase (hAKR1B1). Sandosaponin A can inhibit the reduction of l-idose and 4-hydroxynonenal to varying degrees. The presence of Sandosaponin A reveals the challenges posed by the masking effect of conventional aldehyde reductase inhibitors in mixtures when exploring differential aldehyde reductase inhibitors. The inhibitory mechanism of Sandosaponin A may be related to its mode of action on different substrates .

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