2 Results for "

hAKR1B1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "hAKR1B1" in MCE Product Catalog:

1
Soyasaponin Ba
Soyasaponin Ba
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1 Cited Publications
Cat. No.: HY-N0309
CAS No.: 114590-20-4
Category:  

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields

Target:  

Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc

Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .
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Sandosaponin A
Sandosaponin A
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Cat. No.: HY-107302
CAS No.: 135272-91-2
Synonyms: Soyasaponin Bd
Category:  

Triterpenes Leguminosae Terpenoids Plants Phaseolus vulgaris Linn.

Target:  

Endogenous Metabolite

Sandosaponin A (Soyasaponin Bd) is a saponin with inhibitory activity against human recombinant aldehyde reductase (hAKR1B1). Sandosaponin A can inhibit the reduction of l-idose and 4-hydroxynonenal to varying degrees. The presence of Sandosaponin A reveals the challenges posed by the masking effect of conventional aldehyde reductase inhibitors in mixtures when exploring differential aldehyde reductase inhibitors. The inhibitory mechanism of Sandosaponin A may be related to its mode of action on different substrates .
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