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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

human TRPV4 channels

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18662
    RQ-00203078
    5+ Cited Publications

    		 TRP Channel Neurological Disease Cancer
    RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .
    RQ-00203078
  • HY-19976
    RN-1747
    5 Publications Verification

    		 TRP Channel Cardiovascular Disease Metabolic Disease
    RN-1747 is a selective TRPV4 channel agonist, with EC50 values of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 acts as an antagonist of TRPM8, with an IC50 of 4 μM. Topical cutaneous administration of RN-1747 induces hypothermia, increases tail heat loss via cutaneous vasodilation, and promotes cold-seeking behavior in rats. Intracerebroventricular administration of RN-1747 does not induce hypothermia in rats .
    RN-1747
  • HY-110270
    RN-9893

    		TRP Channel Inflammation/Immunology
    RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively .
    RN-9893

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