Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
insoluble peptide
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "insoluble peptide" in MCE Product Catalog:
27
Target:
Research Areas:
β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
27
27 Publications Verification
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: Amyloid β-peptide (1-42) (human)
Target:
Research Areas:
β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
27
27 Publications Verification
Cat. No.: HY-P1363B
CAS No.: 107761-42-2
Target:
Research Areas:
β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
Cat. No.: HY-P4882A
Target:
Research Areas:
Cat. No.: HY-P1387
CAS No.: 144409-98-3
Research Areas:
Cat. No.: HY-151786
CAS No.: 2408993-33-7
Target:
Research Areas:
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-W004128
CAS No.: 73401-74-8
Synonyms: 4HMPAA
Target:
Research Areas:
4-(Hydroxymethyl)phenylacetic acid can serve as the main body of insoluble polypeptide. 4-(Hydroxymethyl)phenylacetic acid can react with DEPBT and 4-acetylaniline to form amide intermediates. 4-(Hydroxymethyl)phenylacetic acid is a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota. 4-(Hydroxymethyl)phenylacetic acid significantly inhibits 6-MP oxidation and has no significant inhibition on xanthine oxidation .
Cat. No.: HY-P1363S1
Target:
Research Areas:
Cat. No.: HY-P5906
Synonyms: Citrullinated Aβ (1-40); Citrullinated Aβ40
Target:
Research Areas:
Cat. No.: HY-151787
CAS No.: 2408993-39-3
Target:
Research Areas:
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-P0248F1
Research Areas:
Kemptide-FITC is a fluorescently labeled Kemptide (HY-P0248). Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA). Kemptide-FITC enables the quantification of PKA activity and can also indirectly determine cAMP concentrations through the activation of PKA in sperm insoluble fractions. Kemptide-FITC is applicable for kinase mobility shift assay (KiMSA), and its fluorescent signal shows a linear response with increasing peptide amount within a specific range on agarose gels .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
