Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
late endosomes/lysosomes
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "late endosomes/lysosomes" in MCE Product Catalog:
18
Cat. No.: HY-DY1040
CAS No.: 231946-72-8
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-162160
CAS No.: 1221739-85-0
Cat. No.: HY-D2465
Target:
Research Areas:
CY5-Dextran (MW60-80k) is a fluorescent probe formed by covalent conjugation of the cyanine dye Cy5 to dextran. It is a pH-insensitive fluid-phase endocytosis tracer (the pH of endosomal lumen is precisely quantified by the fluorescence ratio of FITC/Cy5). CY5-Dextran (MW60-80k) is internalized by cells via a clathrin-independent fluid-phase pinocytosis pathway, and is sequentially evidenced by early endosomes, late endosomes are transported to lysosomes. CY5-D I cannot pass through the limited pore size formed by uncoating of human rhinovirus type 2 (HRV2), but can be released into the neutral cytoplasm upon adenovirus-mediated endosomal rupture, thus distinguishing between the two viral modes of "pore-forming escape" and "lysis escape". CY5-Dextran (MW60) -80k) has an excitation wavelength of 635 nm, and it can also be used for time-lapse imaging of endocytosis dynamics of stromal cells in tissues such as rat salivary glands under in vivo two-photon microscopy .
Cat. No.: HY-177120
CAS No.: 133156-42-0
DMBP is a VPS41 inhibitor. DMBP induces methuosis and inhibits autophagy in cancer cells. DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes. DMBP effectively inhibits metastasis in a mouse metastatic melanoma model. DMBP can be used for the study of melanoma .
Cat. No.: HY-D2321
CAS No.: 2324152-35-2
Cat. No.: HY-165426
CAS No.: 3031522-14-9
Target:
Research Areas:
HB-230 is a Transglutaminase-2 (TG2) (human IC50 = 4.9 μM) inhibitor and a selective fluorescent imaging probe for active TG2 localization. HB-230 modifies TG2 Cys277 to sustain the enzyme open conformation. HB-230 forms a ternary complex with TG2 and α2-macroglobulin, undergoes receptor-mediated endocytosis, and trafficks directly to lysosomes without early/late endosome fusion. HB-230 exhibits TG2 activity-dependent and α2-macroglobulin-dependent uptake. HB-230 can be used for the research of celiac disease, (Ex/Em = 649/665 nm) .
Cat. No.: HY-D3163
Target:
Research Areas:
Endo-pH is a cell-permeable, pH-responsive fluorescent probe based on BODIPY, with a pKa of 5.08. When pH decreases from 7.32 to 4.97, Endo-pH undergoes protonation under acidic conditions, resulting in a 79-fold increase in fluorescence intensity at 786 nm. The detection wavelengths of its protonated form are Ex/Em=688/786 nm, while the absorption wavelength of its non-protonated form is 745 nm. Endo-pH can be used for staining late endosomes in live cells and determining the fusion time of late endosomes and lysosomes .
Cat. No.: HY-W339816
CAS No.: 325466-03-3
Research Areas:
(S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.
Cat. No.: HY-D3130
Target:
Research Areas:
Mem-pH is a ratiometric fluorescent probe used for measuring vesicular pH. Mem-pH inserts into the plasma membrane bilayer and localizes to the vesicular lumen, switching between its basic and acidic forms via protonation during vesicular acidification to enable ratiometric pH readout. In aqueous media, Mem-pH forms non-emissive aggregates through aggregation-induced quenching, and then depolymerizes and recovers its fluorescent activity upon binding to the plasma membrane. The excitation/emission wavelengths of the basic form of Mem-pH are 405/450-550 nm, while those of the acidic form are 488/500-700 nm .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
