![[MePhe7]-Neurokinin B](https://file.medchemexpress.com/product_pic/hy-p3862.gif "Click to View [MePhe7]-Neurokinin B Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
neurokinin-B
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "neurokinin-B" in MCE Product Catalog:
Cat. No.: HY-P0242
CAS No.: 86933-75-7
6
6 Cited Publications
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SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders .
Cat. No.: HY-P0242A
CAS No.: 101536-55-4
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
Cat. No.: HY-P3862
CAS No.: 110880-53-0
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Cat. No.: HY-P3847
CAS No.: 131019-53-9
Synonyms: Tyr-NKB
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Cat. No.: HY-P3850
CAS No.: 109212-72-8
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Cat. No.: HY-116822
CAS No.: 264618-44-2
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SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM .
Cat. No.: HY-P71349
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TAC3; Tachykinin-3; Prev. NKNB; neurokinin-B Protein; ZNEUROK1; Preprotachykinin-B; LncZBTB39-1:2; Gamma Tachykinin 3; LncZBTB39; Preprotachykinin B; NKB; neurokinin Beta; NK3; PRO1155; Neuromedin K; HH10; Tachykinin 3; Tachykinin Precursor 3; neurokinin
Species:
Human
Source:
E. coli
Cat. No.: HY-116268
CAS No.: 1133706-08-7
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GSK256471 is a non-peptide tachykinin NK3 receptor antagonist with a pKi of 8.9 for the human recombinant NK3 receptor and 8.4 for the guinea pig native receptor. GSK256471 exhibits >100-fold selectivity for NK1 (pKi = 5.2) and NK2 (pKi = 7.3) receptors. GSK256471 noncompetitively inhibits neurokinin B (NKB) (HY-P0242)-induced inositol phosphate accumulation, and this inhibition is irreversible. GSK256471 inhibits wet dog shaking behavior and suppresses dopamine release. GSK256471 could be used to study schizophrenia .
Cat. No.: HY-19633A
CAS No.: 216776-73-7
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CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
