216776-73-7
Chemical Structure
CS-003
- CAS No.: 216776-73-7
- Formula:C34H39Cl3N2O6S
- Molecular Weight:710.11
InChIKey: IHDDYKNRVLPVEV-XSBGGQKVSA-N
SMILES: O=S1C2(CCN(CC2)CC[C@@]3(C4=CC(Cl)=C(C=C4)Cl)CN(CCO3)C(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6C1.Cl
Biological Activity: CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists[1].
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CS-003 | CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists. | |||||||||||||||||||||
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Keywords
