5 Results for "

neuromyelitis optica spectrum disorders

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "neuromyelitis optica spectrum disorders" in MCE Product Catalog:

Cat. No.: HY-P99112
CAS No.: 1535963-91-7
Synonyms: RG-6168; SA-237

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .
loading...
    loading...
Cat. No.: HY-P2459
CAS No.: 163158-19-8
Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

MOG (35-55), human is a synthetic encephalitogenic peptide fragment (residues 35-55) of human myelin oligodendrocyte glycoprotein, and also serves as a myelin oligodendrocyte glycoprotein peptide epitope. MOG (35-55), human induces mild central nervous system inflammation in mice, but does not trigger demyelinating lesions, only causing mild clinical neurological symptoms. MOG (35-55) induces experimental autoimmune encephalomyelitis mouse models that recapitulate the features of optic neuritis, multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated diseases, and neuromyelitis optica spectrum disorders .
loading...
    loading...
Cat. No.: HY-W668775
CAS No.: 871100-12-8
Quin-C7 is an orally active FPR2/ALX antagonist. Quin-C7 binds to the orthosteric ligand-binding pocket of FPR2/ALX, modulates receptor activation, and inhibits pro-inflammatory ERK signaling mediated by serum amyloid A (SAA). Quin-C7 reduces pro-inflammatory mediators TNF-α levels, increases anti-inflammatory IL-10, decreases inflammatory neutrophils and pro-inflammatory M1 macrophages, downregulates ERK1/2 phosphorylation, and upregulates JNK1/2/3 phosphorylation. Quin-C7 blocks FPR2/mFpr2 signaling, reduces brain lesion volume. Quin-C7 can be used for the research of inflammatory bowel disease and neuromyelitis optica spectrum disorder .
loading...
    loading...
Cat. No.: HY-P991869
Synonyms: AQmabAM; rAb-53

Target:  

Aquaporin

Research Areas:  

Neurological Disease

Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}
loading...
    loading...
Cat. No.: HY-P991514A

Target:  

CD20

Research Areas:  

Cancer

MIL62 (FUT8-KO) is a CD20-targeting antibody that prepared by knocking out the fucosyltransferase 8 gene (FUT8) to remove fucose and thereby enhance the ADCC activity of the antibody .
loading...
    loading...