163158-19-8
Chemical Structure
MOG (35-55), human
- CAS No.: 163158-19-8
- Formula:C120H179N35O28S
- Molecular Weight:2591.99
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](N)CCSC)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O
Biological Activity: MOG (35-55), human is a synthetic encephalitogenic peptide fragment (residues 35-55) of human myelin oligodendrocyte glycoprotein, and also serves as a myelin oligodendrocyte glycoprotein peptide epitope. MOG (35-55), human induces mild central nervous system inflammation in mice, but does not trigger demyelinating lesions, only causing mild clinical neurological symptoms. MOG (35-55) induces experimental autoimmune encephalomyelitis mouse models that recapitulate the features of optic neuritis, multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated diseases, and neuromyelitis optica spectrum disorders[1][2].
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MOG (35-55), human | 98.10% | MOG (35-55), human is a synthetic encephalitogenic peptide fragment (residues 35-55) of human myelin oligodendrocyte glycoprotein, and also serves as a myelin oligodendrocyte glycoprotein peptide epitope. MOG (35-55), human induces mild central nervous system inflammation in mice, but does not trigger demyelinating lesions, only causing mild clinical neurological symptoms. MOG (35-55) induces experimental autoimmune encephalomyelitis mouse models that recapitulate the features of optic neuritis, multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated diseases, and neuromyelitis optica spectrum disorders. | ||||||||||||||||||||
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References
- [1]. Albouz-Abo S, et al. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. European journal of biochemistry. 1997 May 15;246(1):59-70. [Content Brief]
- [2]. Capper EN, et al. MOG-induced EAE model of optic nerve inflammation compared to MS, MOGAD and NMOSD related subtypes of human optic neuritis. Journal of neuroinflammation. 2025 Apr 07;22(1):102. [Content Brief]
