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nicotine metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (5) Isotope-Labeled Compounds (1) mAChR (2) nAChR (3) Opioid Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (6) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W104368

Nicotinic acid riboside	Endogenous Metabolite	Metabolic Disease Cancer
Nicotinic acid riboside is a NAD ⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD ⁺ metabolism .

HY-121027

Anagyrine (-)-Anagyrine; Monolupine; Rhombinine	mAChR nAChR	Neurological Disease
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to *muscarinic and nicotinic* acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR*, and Anagyrine can directly, without metabolism*, desensitize nAChR .

HY-B0143A

Niacin hydrochloride Nicotinic acid hydrochloride; Vitamin B3 hydrochloride	Endogenous Metabolite Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

HY-155456

CYP2A6-IN-1	Cytochrome P450	Metabolic Disease
CD-6 is a flavonoid CYP2A6 inhibitor (IC₅₀: 1.566 μM). CYP2A6 inhibits the metabolism of nicotine to cotinine, resulting in an increase in the amount of nicotine available in the blood, leading to increased smoking behavior. CD-6 mediates CYP2A6 inhibition and can be used in research on smoking cessation or smoking-related diseases .

HY-W015467

Pyridine-3-sulfonic acid Pyridine-3-sulphonic acid	Drug Derivative	Metabolic Disease
Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid .

HY-W856819

Eseroline	Opioid Receptor Cholinesterase (ChE) Drug Metabolite nAChR	Neurological Disease
Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its K_i values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease .

HY-W742088

Nicotinic acid riboside-d4	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Nicotinic acid riboside-d₄ is the deuterium labeled Nicotinic acid riboside (HY-W104368). Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism .

HY-160251

3-HC-Gluc (3'R,5k'S)-trans-3'-Hydroxycotinine glucuronide	Drug Metabolite	Others
3-HC-Gluc ((3’R,5k’s)-trans-3’ -Hydroxycotinine glucuronide) The trans-structure of 3-HC, the main metabolite of nicotine .

HY-121027A

Anagyrine hydrochloride (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride	mAChR nAChR	Neurological Disease
Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to *muscarinic and nicotinic* acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR*, and Anagyrine hydrochloride can directly, without metabolism*, desensitize nAChR .

HY-W104368R

Nicotinic acid riboside (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease Cancer
Nicotinic acid riboside (Standard) is the analytical standard of Nicotinic acid riboside (HY-W104368). This product is intended for research and analytical applications. Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism .

HY-P3241A

Nucleoside Phosphorylase, bacterial	Endogenous Metabolite	Metabolic Disease
Nucleoside Phosphorylase, bacterial (EC 2.4.2.1), is a pentosesyltransferase. Nucleoside Phosphorylase participates in three metabolic pathways: purine metabolism, pyrimidine metabolism, and nicotinic acid and nicotinamide metabolism. Its two substrates are purine nucleosides and phosphates, and its two products are purines and α-D-ribose-1-phosphate.

Pyridine-3-sulfonic acid Pyridine-3-sulphonic acid	Biochemical Assay Reagents
Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W104368

Nicotinic acid riboside	Alkaloids Classification of Application Fields Agrostidoideae Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Triticum aestivum L. Source Classification	Endogenous Metabolite
Nicotinic acid riboside is a NAD ⁺ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD ⁺ metabolism .

HY-121027

Anagyrine (-)-Anagyrine; Monolupine; Rhombinine	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Plants Disease Research Fields Lupinus albus Linn. Cancer Source Classification	mAChR nAChR
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to *muscarinic and nicotinic* acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR*, and Anagyrine can directly, without metabolism*, desensitize nAChR .

HY-B0143A

Niacin hydrochloride Nicotinic acid hydrochloride; Vitamin B3 hydrochloride	Alkaloids Classification of Application Fields Ketones, Aldehydes, Acids Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases .

HY-121027A

Anagyrine hydrochloride (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride	Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Source Classification	mAChR nAChR
Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to *muscarinic and nicotinic* acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR*, and Anagyrine hydrochloride can directly, without metabolism*, desensitize nAChR .

HY-W104368R

Nicotinic acid riboside (Standard)	Alkaloids Structural Classification Agrostidoideae Pyridine Alkaloids Plants Triticum aestivum L. Source Classification	Endogenous Metabolite Reference Standards
Nicotinic acid riboside (Standard) is the analytical standard of Nicotinic acid riboside (HY-W104368). This product is intended for research and analytical applications. Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism .

Cat. No.	Product Name	Chemical Structure

HY-W742088

Nicotinic acid riboside-d4
Nicotinic acid riboside-d₄ is the deuterium labeled Nicotinic acid riboside (HY-W104368). Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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