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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
platelet-derived growth factor receptor beta
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "platelet-derived growth factor receptor beta" in MCE Product Catalog:
4
4 Cited Publications
Research Areas:
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
4
Research Areas:
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
2
2 Cited Publications
Cat. No.: HY-P990859
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-W011266
CAS No.: 627518-40-5
JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM) .
Cat. No.: HY-160053
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM .
Synonyms: SIM010603
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .
Cat. No.: HY-162888
CAS No.: 2376694-72-1
Research Areas:
WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .
Cat. No.: HY-13894R
CAS No.: 146535-11-7
Synonyms: AG1296 (Standard)
Target:
Research Areas:
Tyrphostin AG1296 (Standard) is the analytical standard of Tyrphostin AG1296. This product is intended for research and analytical applications. Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma .
Cat. No.: HY-174548
Human PDGFRB mRNA encodes the human platelet derived growth factor receptor beta (PDGFRB) protein, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRB is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.
Cat. No.: HY-P86327
Synonyms: PDGFRB; PDGFR; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P82180
Synonyms: PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P83737
Synonyms: PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P83317
Synonyms: PDGFRB; PDGFR; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P82180A
Synonyms: PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P702756
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PDGFRB; PDGFR-beta; Prev. PDGFR; beta platelet-derived growth factor receptor; PDGFR1; Activated Tyrosine Kinase PDGFRB; CD140b; CD140b Antigen; JTK12; NDEL1-PDGFRB; platelet-derived growth factor receptor, beta Polypeptide; IBGC4; beta-Type platelet-derived growth factor receptor; OPDKD; platelet-derived growth factor receptor beta; PENTT; platelet-derived growth factor receptor 1; IMF1; CD140 Antigen-Like Family Member B; KOGS; PDGF-R-beta; platelet derived growth factor receptor beta; PDGFR-1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85320
Synonyms: PDGFRB; PDGFR; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri
Cat. No.: HY-P80278
Synonyms: CD140b, PDGFR, PDGFR1, PDGFRB, platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, platelet-derived growth factor receptor 1, PDGFR-1
Cat. No.: HY-P74644
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDGFRB; PDGFR-beta; Prev. PDGFR; beta platelet-derived growth factor receptor; PDGFR1; Activated Tyrosine Kinase PDGFRB; CD140b; CD140b Antigen; JTK12; NDEL1-PDGFRB; platelet-derived growth factor receptor, beta Polypeptide; IBGC4; beta-Type platelet-Deri
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
