2644673-07-2
2644673-07-2
Chemical Structure
PDGFR-IN-1
- CAS No.: 2644673-07-2
- Formula:C25H30N8O
- Molecular Weight:458.56
IUPAC Name: N2-(4-(4-ethylpiperazin-1-yl)-3-methoxyphenyl)-N4-(1H-indazol-6-yl)-5-methylpyrimidine-2,4-diamine
InChIKey: PQIKUMYNSRASMV-UHFFFAOYSA-N
SMILES: CC1=CN=C(N=C1NC2=CC3=C(C=C2)C=NN3)NC4=CC=C(C(OC)=C4)N5CCN(CC5)CC
Biological Activity: PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma[1].
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PDGFR-IN-1 | 98.84% | PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma. | ||||||||||||||||||||
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