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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
progesterone receptor membrane component-1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "progesterone receptor membrane component-1" in MCE Product Catalog:
Cat. No.: HY-115625
CAS No.: 1375078-57-1
Research Areas:
AG-205 is a progesterone receptor membrane component 1 (PGRMC1) antagonist and CGT inhibitor, with an IC50 of 50 μM against rat CGT. AG-205 exhibits antimitotic, antimigratory and anti-invasive activities. AG-205 increases the expression of genes encoding cholesterol biosynthesis pathway or steroidogenic enzymes. AG-205 promotes the regulation of cell cycle by apoptosis and reduces the migratory and invasive capacities of ovarian and breast cancer cells. AG-205 can be used in research related to renal cancer and breast cancer .
Cat. No.: HY-121012
CAS No.: 442656-02-2
Research Areas:
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .
Cat. No.: HY-P87283
Synonyms: HPR6.6 antibody; membrane associated progesterone receptor component 1 antibody; membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; progesterone binding protein antibody; progesterone receptor membrane component 1 antibody
Cat. No.: HY-P87283A
Synonyms: HPR6.6 antibody; membrane associated progesterone receptor component 1 antibody; membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; PGRMC antibody; Pgrmc1 antibody; progesterone binding protein antibody; progesterone receptor membrane component 1 antibody
Cat. No.: HY-116968
CAS No.: 2089059-30-1
Target:
Research Areas:
JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
