Search Result

Results for "

prolyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIF/HIF Prolyl-Hydroxylase (52) Prolyl Endopeptidase (PREP) (45) Akt (1) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (3) Antibiotic (1) Apoptosis (13) Autophagy (2) Bacterial (7) Biochemical Assay Reagents (2) Bradykinin Receptor (1) Calcium Channel (7) Cannabinoid Receptor (1) Carboxypeptidase (1) Caspase (1) Cathepsin (1) CETP (1) Collagen (1) COX (2) Cyclophilin (2) Deubiquitinase (1) Dipeptidyl Peptidase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (8) Drug Derivative (2) Drug Intermediate (2) Drug Metabolite (3) Endogenous Metabolite (6) ERK (1) FAP (4) Ferroptosis (3) FKBP (3) Fluorescent Dye (4) Fungal (2) GLUT (1) HCV (1) iGluR (1) IKZF Family (1) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (2) JNK (2) Ligands for E3 Ligase (1) MDM-2/p53 (2) MicroRNA (1) Microtubule/Tubulin (1) MMP (4) Molecular Glues (1) mTOR (2) Neprilysin (1) NF-κB (3) NO Synthase (2) Parasite (10) PIN1 (9) PINK1/Parkin (2) Polo-like Kinase (PLK) (1) PPAR (3) Reactive Oxygen Species (ROS) (6) Reference Standards (19) Ser/Thr Protease (3) Sodium Channel (7) STAT (1) TGF-beta/Smad (7) TGF-β Receptor (1) Thrombin (1) Wnt (1) α-synuclein (1) β-catenin (1)
By Research Areas:	Cancer (59) Cardiovascular Disease (30) Endocrinology (3) Infection (26) Inflammation/Immunology (32) Metabolic Disease (24) Neurological Disease (26)

By Targets:

HIF/HIF Prolyl-Hydroxylase (52)

Prolyl Endopeptidase (PREP) (45)

Akt (1)

Amino Acid Derivatives (2)

Aminoacyl-tRNA Synthetase (3)

Antibiotic (1)

Apoptosis (13)

Autophagy (2)

Bacterial (7)

Biochemical Assay Reagents (2)

Bradykinin Receptor (1)

Calcium Channel (7)

Cannabinoid Receptor (1)

Carboxypeptidase (1)

Caspase (1)

Cathepsin (1)

CETP (1)

Collagen (1)

COX (2)

Cyclophilin (2)

Deubiquitinase (1)

Dipeptidyl Peptidase (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (8)

Drug Derivative (2)

Drug Intermediate (2)

Drug Metabolite (3)

Endogenous Metabolite (6)

ERK (1)

FAP (4)

Ferroptosis (3)

FKBP (3)

Fluorescent Dye (4)

Fungal (2)

GLUT (1)

HCV (1)

iGluR (1)

IKZF Family (1)

Influenza Virus (1)

Interleukin Related (2)

Isotope-Labeled Compounds (2)

JNK (2)

Ligands for E3 Ligase (1)

MDM-2/p53 (2)

MicroRNA (1)

Microtubule/Tubulin (1)

MMP (4)

Molecular Glues (1)

mTOR (2)

Neprilysin (1)

NF-κB (3)

NO Synthase (2)

Parasite (10)

PIN1 (9)

PINK1/Parkin (2)

Polo-like Kinase (PLK) (1)

PPAR (3)

Reactive Oxygen Species (ROS) (6)

Reference Standards (19)

Ser/Thr Protease (3)

Sodium Channel (7)

STAT (1)

TGF-beta/Smad (7)

TGF-β Receptor (1)

Thrombin (1)

Wnt (1)

α-synuclein (1)

β-catenin (1)

By Research Areas:

Cancer (59)

Cardiovascular Disease (30)

Endocrinology (3)

Infection (26)

Inflammation/Immunology (32)

Metabolic Disease (24)

Neurological Disease (26)

162

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Prolyl Endopeptidase (PREP) HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13426

Roxadustat Maximum Cited Publications 59 Publications Verification FG-4592	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Infection Cancer
Roxadustat is an orally active *hypoxia-inducible factor prolyl-hydroxylase (PHD)* inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-N0109

Salidroside Maximum Cited Publications 44 Publications Verification Rhodioloside	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)	Cancer
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-17608

Daprodustat 15+ Cited Publications GSK1278863	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Daprodustat (GSK1278863) is an orally active *hypoxia-inducible factor prolyl* hydroxylase (HIF-PH)** inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

HY-D1670

Z-Gly-Pro-AMC 3 Publications Verification	Fluorescent Dye	Others
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-Amino-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

HY-109057

Enarodustat 4 Publications Verification JTZ-951; SAL0951	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
Enarodustat is a potent and orally active *hypoxia-inducible factor prolyl* hydroxylase inhibitor, with an EC₅₀** of 0.22 μM. Enarodustat has the potential for renal anemia treatment.

HY-100684

UAMC-1110 2 Publications Verification	Prolyl Endopeptidase (PREP) FAP	Cancer
UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC₅₀ of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC₅₀ of 1.8 μM .

HY-139361

Sulfopin 3 Publications Verification PIN1-3	PIN1	Cancer
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent K_i of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors .

HY-121172

1,4-DPCA 1 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
1,4-DPCA, a potent *prolyl-4-hydroxylase* inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC₅₀ of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM .

HY-N2481

Oroxylin A-7-O-glucuronide 1 Publications Verification Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-P1939

Cyclo(L-Leu-L-Pro) Cyclo(L-prolyl-L-leucyl)	Fungal Bacterial Influenza Virus	Infection
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .

HY-101277

Vadadustat 5+ Cited Publications PG-1016548; AKB-6548	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-120110

IOX4 5+ Cited Publications	HIF/HIF Prolyl-Hydroxylase	Neurological Disease Inflammation/Immunology
IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC₅₀ value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2 .

HY-103068

Diethyl-pythiDC 4 Publications Verification	MMP	Cancer
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

HY-145983

Suc-Gly-Pro-AMC 1 Publications Verification	FAP Prolyl Endopeptidase (PREP)	Cancer
Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .

HY-100475

KYP-2047 1 Publications Verification	Apoptosis MDM-2/p53 Prolyl Endopeptidase (PREP)	Neurological Disease Inflammation/Immunology Cancer
KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an K_i value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation .

HY-15641

FG-2216 5+ Cited Publications IOX3; YM311	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
FG-2216 (IOX3) is a potent and orally active inhibitor of *HIF prolyl* hydroxylase-2 (PHD2), with an IC₅₀** of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo .

HY-N1477

Dencichine Dencichin; ODAP	HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl* hydroxylase-2 (PHD-2)** activity.

HY-101023

MK-8617 3 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC₅₀ of 1 nM for PHD2.

HY-12832

JNJ-42041935	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD; inhibits PHD1, PHD2, and PHD3 with pK_i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.

HY-44809

Izilendustat	HIF/HIF Prolyl-Hydroxylase Bacterial	Cardiovascular Disease Infection Inflammation/Immunology
Izilendustat is a potent prolyl hydroxylase inhibitor. Izilendustat competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia .

HY-113951

Prolyl Endopeptidase Inhibitor 1 Boc-Pro-prolinal; (Boc)-prolyl-prolinal	Prolyl Endopeptidase (PREP)	Neurological Disease
Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a K_i value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect .

HY-17455

Pramiracetam CI-879 free base	Prolyl Endopeptidase (PREP)	Neurological Disease
Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dye	Others
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

HY-P4490

Suc-Ala-Pro-pNA 1 Publications Verification	Prolyl Endopeptidase (PREP)	Others
Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .

HY-129079A

TFMB-(S)-2-HG 2 Publications Verification	DNA Methyltransferase Wnt β-catenin	Endocrinology Cancer
TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the *EglN prolyl* hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, β-catenin** (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML) .

HY-139287

M1002 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase	Cancer
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors .

HY-116716

PIN1 inhibitor API-1 1 Publications Verification	MicroRNA	Cancer
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC₅₀ of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .

HY-122542A

PPACK dihydrochloride 2 Publications Verification Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK dihydrochloride is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK dihydrochloride binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK dihydrochloride also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK dihydrochloride can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-N2454

β-Elemonic acid	Apoptosis Reactive Oxygen Species (ROS) COX Endogenous Metabolite Prolyl Endopeptidase (PREP)	Inflammation/Immunology Cancer
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects .

HY-137220

Z-Gly-Pro-pNA	Prolyl Endopeptidase (PREP)	Others
Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity .

HY-15114

S 17092 1 Publications Verification S 17092-1	Prolyl Endopeptidase (PREP) Apoptosis	Neurological Disease
S 17092 (S 17092-1) is an orally active cerebral prolyl-endopeptidase (PEP) inhibitor with an IC₅₀ of 1.2 nM. S 17092 inhibits cell apoptosis. S 17092 mechanism of action is to inhibit the activity of PEP, slowing down the degradation of neuroactive peptides and thus enhancing memory function. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging .

HY-139648

PREP inhibitor-1	Prolyl Endopeptidase (PREP)	Others
PREP inhibitor-1 (compound 27a) is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC₅₀ < 1 nM).

HY-W404002

BR102910	Prolyl Endopeptidase (PREP)	Metabolic Disease
BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC₅₀ of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC₅₀ of 49.00 μM. BR102910 can be used for the researchof type 2

HY-103070

PythiDC	MMP	Inflammation/Immunology
PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC₅₀ value of 4.0 μM. PythiDC can be used as a CP4H probe and also can be used for the development of a new class of antifibrotic and antimetastatic agents .

HY-161794A

SP3N hydrochloride	FKBP	Cancer
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF ^FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer .

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-119351

BNS	HIF/HIF Prolyl-Hydroxylase	Others
BNS is a cell penetrant, potent and selective PHD2 (prolyl-hydroxylase 2) inhibitor .

HY-P4559

H-Pro-Met-OH	Dipeptidyl Peptidase Drug Intermediate	Others
H-Pro-Met-OH is a dipeptide containing proline and methionine. H-Pro-Met-OH also serves as a substrate for prolinase and prolyl dipeptidase .

HY-151880

Antibacterial agent 124	DNA/RNA Synthesis	Infection
Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC₅₀ of 0.18 μM against Staphylococcus aureus ProRS (SaProRS) .

HY-W009686

H-Pro-Leu-OH L-prolyl-L-leucine; Pro-Leu	Amino Acid Derivatives	Others
H-Pro-Leu-OH is a leucine derivative .

HY-145555

Bersiporocin DWN12088	Aminoacyl-tRNA Synthetase	Inflammation/Immunology
Bersiporocin (DWN12088) is an orally effective prolyl-tRNA synthetase (PRS) inhibitor. Bersiporocin exerts antifibrotic effects by inhibiting collagen synthesis. Bersiporocin can be used in the research of pulmonary fibrosis .

HY-162452

Prolyl endopeptidase inhibitor 2	Prolyl Endopeptidase (PREP)	Neurological Disease
Prolyl endopeptidase inhibitor 2 (Compound 8) was a proline endopeptidase (PEP) inhibitor with IC₅₀ value 31.11 μM. Prolyl endopeptidase inhibitor 2 can be used in the study of neurodegenerative diseases .

HY-13426S

Roxadustat-d5	HIF/HIF Prolyl-Hydroxylase Ferroptosis	Cancer
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-112441

Prolyl Hydroxylase inhibitor 1	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 62.23 nM . Antianemia agent .

HY-129502

Fibrostatin C P-23924C	HIF/HIF Prolyl-Hydroxylase	Others
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-148332

Z-Thioprolyl-Thiazolidine	Prolyl Endopeptidase (PREP)	Neurological Disease
Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor with an K_i value of 0.36 nM for bovine brain prolyl endopeptidase

HY-P4359

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .

HY-109057A

Enarodustat hydrochloride JTZ-951 hydrochloride; SAL0951 hydrochloride	HIF/HIF Prolyl-Hydroxylase	Metabolic Disease
Enarodustat hydrochloride is a potent and orally active HIF/HIF Prolyl-Hydroxylase inhibitor, with an EC₅₀ of 0.22 μM. Enarodustat hydrochloride has the potential for renal anemia treatment.

HY-N8743

Cyclo(Pro-Leu) A 65190; Cyclo-(leucyl-prolyl)	Endogenous Metabolite	Cancer
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .

HY-143475

POP-IN-2	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a K_i of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer .

Cat. No.	Product Name

HY-L173

Anti-Ovarian Cancer Compound Library

2,817 compounds

Ovarian cancer is the most common cause of death in female genital malignancies, with the highest mortality rate in female genital malignancies. It is characterized by difficulty in detection in the early stage of the disease, high recurrence rate and poor prognosis. In fact, ovarian cancer includes many pathologic types. It is usually divided into epithelial ovarian cancer, malignant germ cell tumors and sex cord stromal tumors, of which epithelial ovarian cancer is the most dominant form. Clinical treatment of ovarian cancer prioritizes surgery combined with paclitaxel chemotherapy. However, due to the spread and drug resistance of tumor cells, the recurrence of ovarian cancer is high. In this case, combined with traditional methods, the development of new therapeutic agents can help to improve the treatment effect of ovarian cancer.

MCE designs a unique collection of 2,817 compounds with definite or potential anti-ovarian cancer activity, which mainly targeting the main targets of ovarian cancer such as PARP, ATM/ATR, VEGFR and HIF/HIF Prolyl-Hydroxylase, etc. It is an essential tool for development and research of anti-ovarian compounds.

HY-L045

Oxygen Sensing Compound Library

4,029 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 4,029 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-D1670

Z-Gly-Pro-AMC 3 Publications Verification	Fluorescent Dyes
Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-Amino-4-methylcoumarin (HY-D0027). (λ_ex=380 nm, λ_em=465 nm) .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Fluorescent Dyes
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidyl-prolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA is used to evaluate the inhibitory effect of target compounds on Pin1, the catalytic activity of Pin1, and other related assays .

HY-16710

GPDA 1 Publications Verification GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dyes
GPDA (GPN; Glycylproline p-nitroanilide tosylate) is a chromogenic substrate of prolyl dipeptidyl aminopeptidase. GPDA is used to detect the activity of prolyl dipeptidyl aminopeptidase in human serum .

Cat. No.	Product Name	Target	Research Area

HY-P1939

Cyclo(L-Leu-L-Pro) Cyclo(L-prolyl-L-leucyl)	Fungal Bacterial Influenza Virus	Infection
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidyl-prolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA is used to evaluate the inhibitory effect of target compounds on Pin1, the catalytic activity of Pin1, and other related assays .

HY-P4490

Suc-Ala-Pro-pNA 1 Publications Verification	Prolyl Endopeptidase (PREP)	Others
Suc-Ala-Pro-pNA is a peptide that serves as a substrate to detect the activity and stability of prolyl endopeptidase (PEP) .

HY-P4581

Suc-Ala-Leu-Pro-Phe-pNA Suc-ALPF-pNA	FKBP	Others
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a synthetic polypeptide substrate that targets FK506-binding protein (FKBP). Suc-Ala-Leu-Pro-Phe-pNA can be used to determine peptidyl-prolyl cis-trans isomerase activity via the chymotrypsin-coupled assay. Suc-Ala-Leu-Pro-Phe-pNA serves as a substrate for human FK506-binding protein hFKBP-12 in the chymotrypsin-FKBP coupled PPIase assay. Suc-Ala-Leu-Pro-Phe-pNA is applicable for the detection and research of PPIase activity .

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-P4559

H-Pro-Met-OH	Dipeptidyl Peptidase Drug Intermediate	Others
H-Pro-Met-OH is a dipeptide containing proline and methionine. H-Pro-Met-OH also serves as a substrate for prolinase and prolyl dipeptidase .

HY-W009686

H-Pro-Leu-OH L-prolyl-L-leucine; Pro-Leu	Amino Acid Derivatives	Others
H-Pro-Leu-OH is a leucine derivative .

HY-P4359

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .

HY-W101495

Boc-Leu-OH hydrate N-Boc-L-leucine monohydrate	Amino Acid Derivatives	Others
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-P4308

Z-Pro-Pro-aldehyde-dimethyl acetal	Prolyl Endopeptidase (PREP)	Neurological Disease
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC₅₀= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease .

HY-125432

Poststatin	Prolyl Endopeptidase (PREP)	Metabolic Disease
Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine .

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-P1497

Bradykinin (1-3)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

HY-P3480

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA	Fluorescent Dye	Others
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins .

HY-P4528

Ala-Phe-Pro-βNA	Ser/Thr Protease	Others
Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with K_i values of 88.1 nM and 48.8 nM, respectivley .

HY-P10411

BING	Bacterial	Infection
BING is an antimicrobial peptide that can be isolated from Japanese medaka fish. BING shows a broad-spectrum toxicity against pathogenic bacteria including drug-resistant strains. BING induces a deregulation of periplasmic peptidyl-prolyl isomerases in gram-negative bacteria, and reduces the RNA level of cpxR, which plays a crucial role in the development of antimicrobial resistance .

HY-P11489

RN-0001	Cyclophilin Reactive Oxygen Species (ROS) NF-κB Caspase Apoptosis	Metabolic Disease
RN-0001 is a cyclophilin (Cyp) inhibitor with K_i values of 4.1 nM and 12.0 nM against CypA and CypD, respectively, and an EC₅₀ of 916 nM for CypD. RN-0001 binds directly to CypD, inhibits the peptidyl-prolyl cis-trans isomerase activities of CypD and CypA, and prevents CypD-dependent mitochondrial permeability transition pore opening. RN-0001 improves mitochondrial function, reduces ROS production, inhibits the expression of lipogenic markers, blocks the nuclear translocation of NF-κB p65, and decreases the release of activated caspase-3 and cytochrome c. RN-0001 can be used in the research of alcohol-associated liver disease .

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0843

N-Ethylmaleimide 35+ Cited Publications NEM	Microorganisms Source Classification	Cathepsin Deubiquitinase Apoptosis
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀ value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .

HY-N0109

Salidroside Maximum Cited Publications 44 Publications Verification Rhodioloside	Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Plants Disease Research Fields Cancer	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-N1584

Halofuginone 15+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N2481

Oroxylin A-7-O-glucuronide 1 Publications Verification Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Structural Classification Monophenols Flavonoids Neurological Disease Classification of Application Fields Flavones Labiatae Phenols Plants Medicago truncatula Gaertn. Disease Research Fields Source Classification	Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-N1584A

Halofuginone hydrobromide 15+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1477

Dencichine Dencichin; ODAP	Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Amino acids Plants Araliaceae Source Classification	HIF/HIF Prolyl-Hydroxylase
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit *HIF-prolyl* hydroxylase-2 (PHD-2)** activity.

HY-W016409

Ethyl 3,4-dihydroxybenzoate 1 Publications Verification Protocatechuic acid ethyl ester	Arachis hypogaea L. Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-N2454

β-Elemonic acid	Triterpenes other families Classification of Application Fields Terpenoids Plants Burseraceae Inflammation/Immunology Disease Research Fields Source Classification Boswellia carterii Cancer	Apoptosis Reactive Oxygen Species (ROS) COX Endogenous Metabolite Prolyl Endopeptidase (PREP)
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects .

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-N0109R

Salidroside (Standard) Maximum Cited Publications 44 Publications Verification Rhodioloside (Standard)	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Plants Disease Research Fields Source Classification Cancer	Prolyl Endopeptidase (PREP) mTOR Apoptosis PINK1/Parkin Reference Standards
Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-N1584R

Halofuginone (Standard) RU-19110 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584AR

Halofuginone hydrobromide (Standard) RU-19110 hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-129502

Fibrostatin C P-23924C	Natural Products Microorganisms Source Classification	HIF/HIF Prolyl-Hydroxylase
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-N8743

Cyclo(Pro-Leu) A 65190; Cyclo-(leucyl-prolyl)	Alkaloids Microorganisms Other Alkaloids Source Classification	Endogenous Metabolite
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .

HY-N2481R

Oroxylin A-7-O-glucuronide (Standard) Oroxyloside (Standard); Oroxylin A-7-O-β-D-glucuronide (Standard)	Monophenols Flavonoids Flavones Labiatae Phenols Plants Medicago truncatula Gaertn. Source Classification	Reference Standards Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-N6902

Linderene acetate	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Inflammation/Immunology Disease Research Fields Lindera aggregata (Sims) Kosterm. Source Classification	Prolyl Endopeptidase (PREP)
Linderene acetate, isolated from the root of Lindera strychnifolia, is a prolyl endopeptidase inhibitor .

HY-N6030

(Rac)-Dencichine (Rac)-Dencichin; (Rac)-ODAP	other families Classification of Application Fields Other Diseases Amino acids Plants Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .

HY-123550

Rosenonolactone	Microorganisms Terpenoids Diterpenoids Source Classification	Thrombin CETP
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein .

HY-N15070

Polyozellin	Natural Products Microorganisms Source Classification	Prolyl Endopeptidase (PREP)
Polyozellin is a prolyl endopeptidase inhibitor. Polyozellin has activities against inflammation, cancer, and oxidative stress-related disorders. .

HY-N14218

Eurystatin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A .

HY-N14226

Eurystatin B	Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Eurystatin B is a prolyl endopeptidase (PED) inhibitor. Eurystatin B has a protective effect during Scopolamine (HY-N0296)-induced amnesia in rats .

HY-N15009

Kynapcin-13	Natural Products Microorganisms Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-13 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-13 has a little inhibitory effect on other serine proteases .

HY-N15010

Kynapcin-28	Microorganisms Antibiotics Other Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-28 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-28 has a little inhibitory effect on other serine proteases .

HY-N15055

Propeptin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Propeptin is a peptide antibiotic composed of 19 amino acids. Propeptin has weaker activity against Pseudomonas aeruginosa, Mycobacterium monobacterium, and Xanthomonas oryzae. Propeptin has no effect on KB and L1210 cells of tumor cell lines, but has an inhibitory effect on prolyl endopeptidase .

HY-N16442

Pyrrocidine B	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	Endogenous Metabolite Prolyl Endopeptidase (PREP)
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .

HY-N7538

Dealanylalahopcin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .

HY-N2454R

β-Elemonic acid (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Burseraceae Source Classification Boswellia carterii	Reference Standards Apoptosis Reactive Oxygen Species (ROS) COX Endogenous Metabolite Prolyl Endopeptidase (PREP)
β-Elemonic acid (Standard) is the analytical standard of β-Elemonic acid. This product is intended for research and analytical applications. β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects .

HY-W105272R

2′-Deoxyadenosine 5′-monophosphate disodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-W016409R

Ethyl 3,4-dihydroxybenzoate (Standard) Protocatechuic acid ethyl ester (Standard)	Structural Classification Arachis hypogaea L. Leguminosae Phenols Polyphenols Plants Source Classification	Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

HY-N11615A

(R,R)-Cyclo(Pro-Val)	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Drug Derivative
(R,R)-Cyclo(Pro-Val) is a trans (D-L) diastereoisomer of valyl-prolyl diketopiperazine (cyclic dipeptide) .

Species:	Human (33) Rat (1) Mouse (6) E.coli (2) Cynomolgus (1)
Tag:	SUMO (3) His (33) Tag Free (6) GST (1) Trx (1) Fc (4)
Source:	HEK293 (16) Sf9 insect cells (3) E. coli (25)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73692

	Prolyl Endopeptidase/PREP Protein, Mouse (sf9, His) prolyl endopeptidase; PE; Prep; Pep	Mouse	Sf9 insect cells
	The prolyl endopeptidase (PREP) protein is an enzyme capable of cleaving peptide bonds at the C-terminus of prolyl residues within peptides, particularly peptides up to about 30 amino acids in length.This enzymatic activity suggests a role for PREP in selective processing of peptides, particularly toward proline-containing substrates.Prolyl Endopeptidase/PREP Protein, Mouse (sf9, His) is the recombinant mouse-derived Prolyl Endopeptidase/PREP protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703584

	Prolyl Endopeptidase/PREP Protein, Human PEP	Human	E. coli
	Prolyl Endopeptidase/PREP Protein, Human is the recombinant human-derived PREP, expressed by E. coli , with tag Free labeled tag.

HY-P70047

	*Peptidyl-prolyl* cis-trans isomerase A/CYPA Protein, Human (solution)** rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human (solution) is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P70047A

	*Peptidyl-prolyl* cis-trans isomerase A/CYPA Protein, Human (Tag Free)** rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P71205

	PIN4 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Parvulin-14; Parvulin-17; Peptidyl-prolyl cis-trans isomerase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; Rotamase Pin4; PIN4	Human	E. coli
	PIN4 isoform 1 functions as a ribosomal RNA processing factor in ribosome biogenesis and interacts with tightly bent AT-rich stretches of double-stranded DNA. Meanwhile, PIN4 isoform 2 specifically binds to double-stranded DNA. PIN4 Protein, Human (His) is the recombinant human-derived PIN4 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P706012

	EGLN1 Protein, Human (His) Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2); prolyl hydroxylase domain-containing protein 2 (PHD2); SM-20; C1orf12; PNAS-118; PNAS-137	Human	E. coli

HY-P703327

	EGLN1 Protein, Human (246a.a, His) C1orf12; PNAS-118; PNAS-137; Egl nine homolog 1; Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2); prolyl hydroxylase domain-containing protein 2 (PHD2)	Human	E. coli
	EGLN1 Protein, Human (246a.a, His) is the recombinant human-derived EGLN1, expressed by E. coli , with His labeled tag.

HY-P70007A

	Cyclophilin A Protein, Mouse 2 Publications Verification rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free.

HY-P71224A

	PPID Protein, Human (His) Peptidyl-prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag.

HY-P71224

	PPID Protein, Human (His, solution) 1 Publications Verification Peptidyl-prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His, solution) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag.

HY-P70007

	Cyclophilin A Protein, Mouse (solution) rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse (solution) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free.

HY-P75759

	FAP Protein, Cynomolgus (HEK293, His) prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Cynomolgus	HEK293
	FAP Protein is a type II transmembrane serine protease, a member of the propionyl peptidase family, that promotes cell invasion and tumor growth. FAP protein has the function of enhancing blood coagulation. FAP Protein is associated with a variety of human pathology, including fibrosis, arthritis, atherosclerosis, autoimmune diseases, metabolic diseases and cancer. FAP Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FAP protein, expressed by HEK293 , with N-His labeled tag.

HY-P704585

	FAP Protein, Human (HEK293, hFc) prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (HEK293, hFc) is the recombinant human-derived FAP protein, expressed by HEK293, with N-hFc labeled tag.

HY-P72659A

	FAP Protein, Human (HEK293, N-His) 2 Publications Verification prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (HEK293, His) is the recombinant human-derived FAP protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P77521

	FAP Protein, Human (Biotinylated, HEK293, His) prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FAP Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived FAP protein, expressed by HEK293 , with N-His labeled tag.

HY-P74211A

	Cyclophilin F/PPIF Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700260

	Aminopeptidase P1 Protein, Human (His-SUMO) Aminoacylproline aminopeptidase; aminopeptidase P, cytosolic; APP1; Cytosolic aminopeptidase P; RP11 451M19.1; sAmp; Soluble aminopeptidase P; soluble; X Pro aminopeptidase 1; X prolyl aminopeptidase (aminopeptidase P) 1; X prolyl aminopeptidase (Aminopeptidase P) 1 soluble; X prolyl aminopeptidase 1; X prolyl aminopeptidase 1 soluble; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1; Xaa Pro aminopeptidase 1; Xaa-Pro aminopeptidase 1; XPNPEP 1; XPNPEP; xpnpep1; XPNPEPL; XPNPEPL1; XPP1_HUMAN	Human	E. coli
	Aminopeptidase P1 Protein, a metalloaminopeptidase, crucially catalyzes the removal of penultimate prolyl residues from peptide N-termini, including substrates like Arg-Pro-Pro. This activity significantly contributes to specific peptide degradation, exemplified in bradykinin processing. Aminopeptidase P1's selective prolyl cleavage underscores its importance in modulating peptide structures and functions within biological systems. Aminopeptidase P1 Protein, Human (His-SUMO) is the recombinant human-derived Aminopeptidase P1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P74211

	Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-His labeled tag.

HY-P704586

	FITC-Labeled FAP Protein, Human (HEK293, hFc) prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FITC-Labeled FAP Protein, Human (HEK293, hFc) is the recombinant human-derived FITC-Labeled FAP protein, expressed by HEK293, with N-hFc labeled tag.

HY-P704587

	FITC-Labeled FAP Protein, Human (HEK293, His) prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha	Human	HEK293
	The FAP protein is a cell surface glycoprotein serine protease that is critical for extracellular matrix degradation and plays multiple roles in tissue remodeling, fibrosis, wound healing, inflammation, and tumor growth. FITC-Labeled FAP Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled FAP protein, expressed by HEK293, with N-His labeled tag.

HY-P74212

	Cyclophilin A Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase A; PPIase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag.

HY-P700388

	HP-0175 Protein, Helicobacter pylori (GST) Rotamase HP_0175; Putative peptidyl-prolyl cis-trans isomerase HP_0175	Others	E. coli
	HP-0175 is an antigen secreted by Helicobacter pylori. HP-0175 provides a link between helicobacter pylori-associated inflammation and gastric cancer by promoting the pro-inflammatory low-cytotoxic TIL response, stromal degradation, and pro-angiogenesis pathways. HP-0175 relies on the unfolded protein response (UPR) to autophagy in gastric epithelial cells and induce apoptosis. HP-0175 Protein, Helicobacter pylori (GST) is the recombinant HP-0175 protein, expressed by E. coli , with N-GST labeled tag.

HY-P71223

	PPIC Protein, Human (Trx-His) Peptidyl-prolyl Cis-Trans Isomerase C; PPIase C; Cyclophilin C; Rotamase C; PPIC; CYPC	Human	E. coli
	PPIC protein is a peptidyl-prolyl cis-trans isomerase (PPIase) that actively catalyzes the cis-trans isomerization of prolyl imide peptide bonds, which is a key step in protein folding. Its role in promoting conformational changes ensures correct folding and maturation of proteins, contributing to cellular proteostasis. PPIC Protein, Human (Trx-His) is the recombinant human-derived PPIC protein, expressed by E. coli , with N-Trx, N-6*His labeled tag.

HY-P71225

	PPIE Protein, Human (His) Peptidyl-prolyl Cis-Trans Isomerase E; PPIase E; Cyclophilin E; Cyclophilin-33; Rotamase E; PPIE; CYP33	Human	E. coli
	The PPIE protein is a key spliceosome component that complexly regulates pre-mRNA splicing through RNA binding and PPIase activity. It prefers single-stranded RNA with polyA and polyU stretches, indicating an affinity for the poly(A) region of the 3'-UTR. PPIE Protein, Human (His) is the recombinant human-derived PPIE protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76931

	FKBP14 Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase FKBP14; 22 kDa FKBP; FKBP-22; FKBP-14	Human	HEK293
	The FKBP14 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that uniquely accelerates protein folding, particularly in protein synthesis. FKBP14 particularly favors 4-hydroxyproline-modified substrates, exhibits significant affinity for type III collagen, and has potential effects on type VI and type X collagen. FKBP14 Protein, Human (HEK293, His) is the recombinant human-derived FKBP14 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76344

	FKBP11 Protein, Human (HEK293, Fc) Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase FKBP11; FKBP-19; Rotamase; FKBP-11	Human	HEK293
	The FKBP11 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that plays a crucial role in accelerating protein folding, especially in complex protein synthesis. FKBP11 uses its enzymatic abilities to promote rapid and precise conformational changes that are critical for correct protein folding and maturation. FKBP11 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP11 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76346

	FKBP12 Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Mouse	E. coli
	The FKBP12 protein is multifunctional and critical in TGF-β signaling by maintaining TGFBR1 in an inactive conformation, thereby preventing receptor activation in the absence of ligand. It recruits SMAD7 to ACVR1B, blocks the binding of SMAD2 and SMAD3 to the activin receptor complex, and thereby inhibits activin signaling. FKBP12 Protein, Mouse (His) is the recombinant mouse-derived FKBP12 protein, expressed by E. coli , with N-His labeled tag.

HY-P76345A

	FKBP12 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Human	E. coli

HY-P70333

	FKBP2 Protein, Human (HEK293, His) rHuPeptidyl-prolyl cis-trans isomerase FKBP2 Gene/FKBP2, His; Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short); also named 13 kDa FK506-binding protein; FK506-binding protein 2; Immunophilin FKBP13; Rotamase	Human	HEK293
	FKBP2 protein plays a central role in the complex process of protein folding and is an important peptidyl prolyl cis-trans isomerase (PPIase). Its unique ability to catalyze the cis-trans isomerization of proline imide peptide bonds accelerates dynamic conformational changes that are critical for efficient protein folding. FKBP2 Protein, Human (HEK293, His) is the recombinant human-derived FKBP2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71226

	PPIL1 Protein, Human (His) Peptidyl-prolyl Cis-Trans Isomerase-Like 1; PPIase; Rotamase PPIL1; PPIL1; CYPL1	Human	E. coli
	The PPIL1 protein is a spliceosome component that coordinates pre-mRNA splicing and controls RNA processing. As a peptidylprolyl cis-trans isomerase (PPIase), PPIL1 accelerates protein folding by catalyzing the cis-trans isomerization of proline imide peptide bonds. PPIL1 Protein, Human (His) is the recombinant human-derived PPIL1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76345

	FKBP12 Protein, Human (His, solution) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Human	E. coli
	FKBP12 protein maintains TGFBR1 in an inactive state, inhibits activin signaling by recruiting SMAD7, and modulates RYR1 calcium channel activity. As a PPIase, it speeds up protein folding. FKBP12's multifunctionality underscores its regulatory role in cellular processes, emphasizing its importance in signaling and protein folding. FKBP12 Protein, Human (His) is the recombinant human-derived FKBP12 protein, expressed by E. coli , with C-His labeled tag.

HY-P71477

	FkpA Protein, E.coli (His-SUMO) fkpA; c4121FKBP-type peptidyl-prolyl cis-trans isomerase FkpA; PPIase; EC 5.2.1.8; Rotamase	E.coli	E. coli
	The FkpA protein plays a central role in cellular processes, acting as a key catalyst in the complex dance of protein folding. Its catalytic efficiency is excellent in promoting the cis-trans isomerization of proline-imine peptide bonds, thus accelerating the overall folding of proteins. FkpA Protein, E.coli (His-SUMO) ) is the recombinant E. coli-derived FkpA protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P76932

	FKBP7 Protein, Human (HEK293, Fc) Peptidyl-prolyl Cis-Trans Isomerase FKBP7; FKBP-23; FK506-Binding Protein 7; Rotamase	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70405

	FKBP4 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP4/FKBP4, His; Peptidyl-prolyl cis-trans isomerase FKBP4; 51kDa FK506-binding protein; 51kDa FK506-binding protein; 59kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; immunophilin FKBP52; Rotamase; FKBP4	Human	E. coli
	The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P70403

	FKBP3 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP3/FKBP3, His; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase; FKBP25	Human	E. coli
	FKBP3 is a member of the FK506 and rapamycin-binding protein (FKBP) family and serves as a receptor for the immunosuppressants FK506 and rapamycin, both of which inhibit two distinct cytoplasmic signaling pathways. T cell proliferation. In addition to serving as a receptor for these immunosuppressants, FKBP3, like other peptidyl prolyl cis-trans isomerases (PPIases), also functions to accelerate protein folding. FKBP3 Protein, Human (His) is the recombinant human-derived FKBP3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71501

	PPIase A Protein, E.coli (His-SUMO) ppiA; Z4724; ECs4214; Peptidyl-prolyl cis-trans isomerase A; PPIase A; EC 5.2.1.8; Cyclophilin A; Rotamase A	E.coli	E. coli
	The PPIase A protein plays a central role in complex protein folding, utilizing its peptidyl-prolyl cis-trans isomerase (PPIase) activity to accelerate dynamic conformational changes that are critical for proper protein maturation. PPIase A specifically catalyzes the cis-trans isomerization of proline imide peptide bonds, effectively promoting protein folding. PPIase A Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PPIase A protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P703785

	Aminopeptidase P2 Protein, Rat (HEK293, His) Xaa-Pro aminopeptidase 2; Membrane-bound aminopeptidase P; Membrane-bound APP; mAPP; X-prolyl aminopeptidase 2; Xpnpep2	Rat	HEK293
	Aminopeptidase P2 Protein, Rat (HEK293, His) is the recombinant rat-derived Aminopeptidase P2 protein, expressed by HEK293, with C-His tag.

HY-P703772

	Aminopeptidase P2 Protein, Mouse (HEK293, His) Xaa-Pro aminopeptidase 2; Membrane-bound aminopeptidase P; Membrane-bound APP; mAPP; X-prolyl aminopeptidase 2; Xpnpep2;	Mouse	HEK293
	Aminopeptidase P2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Aminopeptidase P2 protein, expressed by HEK293, with C-His tag.

HY-P71917

	P4HB Protein, Human (His) 1 Publications Verification Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71029

	PPIH Protein, Human (His) Peptidyl-prolyl Cis-Trans Isomerase H; PPIase H; Rotamase H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; CypH; U-snRNP-Associated Cyclophilin SnuCyp-20; USA-CYP; PPIH; CYP20; CYPH	Human	E. coli
	The PPIH protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and may contribute to protein folding. It plays a crucial role in pre-mRNA splicing and contributes to the formation of the U4/U5/U6 tri-snRNP complex in spliceosome assembly. PPIH Protein, Human (His) is the recombinant human-derived PPIH protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701873

	DPP8 Protein, Human (sf9) DPP8; Dipeptidyl peptidase 8; DP8; Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; prolyl dipeptidase DPP8	Human	Sf9 insect cells
	The DPP8 protein cleaves N-terminal dipeptides from proteins with Pro or Ala at position 2. DPP8 Protein, Human (sf9) is the recombinant human-derived DPP8 protein, expressed by sf9 insect cells , with tag free.

HY-P701874

	DPP8 Protein, Human (sf9, His) DPP8; Dipeptidyl peptidase 8; DP8; Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; prolyl dipeptidase DPP8	Human	Sf9 insect cells
	The DPP8 protein cleaves N-terminal dipeptides from proteins with Pro or Ala at position 2. DPP8 Protein, Human (sf9, His) is the recombinant human-derived DPP8 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P71087

	P4HB Protein, Human (HEK293, His) Protein Disulfide-Isomerase; PDI; Cellular Thyroid Hormone-Binding Protein; prolyl 4-Hydroxylase Subunit Beta; p55; P4HB; ERBA2L; PDI; PDIA1; PO4DB	Human	HEK293
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (HEK293, His) is the recombinant human-derived P4HB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70949

	FKBP7 Protein, Human (HEK293, His) Peptidyl-prolyl Cis-Trans Isomerase FKBP7; PPIase FKBP7; 23 kDa FK506-Binding Protein; 23 kDa FKBP; FKBP-23; FK506-Binding Protein 7; FKBP-7; Rotamase; FKBP7; FKBP23	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, His) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-13426S

Roxadustat-d5
Roxadustat-d₅ is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin .

HY-101277S1

Vadadustat-13C6
Vadadustat- ¹³C₆ (PG-1016548- ¹³C₆) is ¹³C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-W101495S

Boc-Leu-OH·H2O-13C
Boc-Leu-OH·H₂O- ¹³C is a ¹³C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-W778057

Ethyl 3,4-Dihydroxybenzoate-13C3

Ethyl 3,4-Dihydroxybenzoate- ¹³C₃ (Protocatechuic acid ethyl ester- ¹³C₃) is the ¹³C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .

Host:	Mouse (5) Rabbit (9)
Reactivity:	Human (14) Rat (9) Mouse (9)
Application:	IHC-P (11) ICC/IF (2) IF-Tissue (1) IP (2) WB (12) FC (2)
Isotype:	IgG (9) IgG1 (4)
Conjugation:	Non-conjugated (14) Biotin (1)
Clonality:	Monoclonal (9) Recombinant (4)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88144

	P4HA3 Antibody (YA7828) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

HY-P88144A

	P4HA3 Antibody (YA7828)(PBS only) 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); alpha III subunit; alpha polypeptide III; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III); procollagen-proline; prolyl 4-hydroxylase	IHC-P	Human, Mouse, Rat
	P4HA3 Antibody (YA7828) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P4HA3.

HY-P87578

	PHD1 Antibody (YA7262) DKFZp434E026 antibody; Egl nine homolog 2 antibody; EGLN 2 antibody; EIT 6 antibody; Estrogen-induced tag 6 antibody; HIF P4H 1 antibody; HIF prolyl hydroxylase 1 antibody; HIF-PH1 antibody; HIF-prolyl hydroxylase 1 antibody; HIFPH 1 antibody; HPH-3 antibody; HPH3 antibody; Hypoxia-inducible factor prolyl hydroxylase 1 antibody; P4H1 antibody; PHD 1 antibody; prolyl hydroxylase domain containing protein 1 antibody	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	PHD1 Antibody (YA7262) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PHD1.

HY-P82857

	Cyclophilin F Antibody (YA2602) PPIF; CYP3; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; Cyclophilin F; Rotamase F	WB, IHC-P	Human, Mouse, Rat
	Cyclophilin F Antibody (YA2602) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclophilin F.

HY-P83230

	*HIF Prolyl* Hydroxylases Antibody (YA2975)** PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM	WB, IHC-P, IP	Human
	HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.

HY-P82857A

	Cyclophilin F Antibody (YA2602)(PBS only) PPIF; CYP3; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; Cyclophilin F; Rotamase F	WB, IHC-P	Human, Mouse, Rat
	Cyclophilin F Antibody (YA2602) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclophilin F.

HY-P83230A

	*HIF Prolyl* Hydroxylases Antibody (YA2975)(PBS only)** PH4; PH-4; PHD4; EGLN4; HIDEA; HIFPH4; P4H-TM	WB, IHC-P, IP	Human
	HIF Prolyl Hydroxylases Antibody (YA2975) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF Prolyl Hydroxylases.

HY-P80638

	Cyclophilin B Antibody (YA787) PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP	WB, IHC-P	Human, Rat, Mouse
	Cyclophilin B Antibody (YA787) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclophilin B.

HY-P85744

	Cyclophilin B Antibody (YA5436) PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP	WB, IHC-P, ICC/IF	Human, Rat, Mouse
	Cyclophilin B Antibody (YA5436) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclophilin B.

HY-P80638A

	Cyclophilin B Antibody (YA787)(PBS only) PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP	WB, IHC-P	Human, Rat, Mouse
	Cyclophilin B Antibody (YA787) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclophilin B.

HY-P86275

	PPIL1 Antibody (YA5967) PPIL1; CYPL1; CGI-124; UNQ2425/PRO4984; Peptidyl-prolyl cis-trans isomerase-like 1 ; PPIase; Rotamase PPIL1;	WB, FC	Human
	PPIL1 Antibody (YA5967) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPIL1.

HY-P86673

	FAP Antibody (YA6365) prolyl endopeptidase FAP; FAPA; Fibroblast activation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; Fibroblast activation protein alpha; Integral membrane serine protease; SEPR_HUMAN; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.	WB	Human
	FAP Antibody (YA6365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAP.

HY-P86673A

	FAP Antibody (YA6365)(PBS only) prolyl endopeptidase FAP; FAPA; Fibroblast activation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; Fibroblast activation protein alpha; Integral membrane serine protease; SEPR_HUMAN; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.	WB	Human
	FAP Antibody (YA6365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FAP.

HY-P86940

	LAP3 Antibody (YA6633) AMPL_HUMAN antibody; Cytosol aminopeptidase antibody; epididymis secretory protein Li 106 antibody; HEL-S-106 antibody; LAP 3 antibody; LAP antibody; LAP-3 antibody; Lap3 antibody; LAPEP antibody; Leucine aminopeptidase 3 antibody; AMPL_HUMAN antibody; Cytosol aminopeptidase antibody; epididymis secretory protein Li 106 antibody; HEL-S-106 antibody; LAP 3 antibody; LAP antibody; LAP-3 antibody; Lap3 antibody; LAPEP antibody; Leucine aminopeptidase 3 antibody; Leucyl aminopeptidase antibody; PEPS antibody; Peptidase S antibody; Proline aminopeptidase antibody; prolyl aminopeptidase antibody;	WB, IHC-P	Human, Mouse, Rat
	LAP3 Antibody (YA6633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LAP3.