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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
purinergic P2X2/3 receptors
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "purinergic P2X2/3 receptors" in MCE Product Catalog:
Cat. No.: HY-108673
CAS No.: 134362-79-1
Target:
Research Areas:
Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM) .
Cat. No.: HY-137610A
Target:
Research Areas:
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg) [1][2].
Cat. No.: HY-189007
Target:
Research Areas:
P2X2/3-antagonist-1 is a P2X2/3 purinergic receptor antagonist and taste blocker. P2X2/3-antagonist-1 binds to an allosteric site, induces a concentration-dependent rightward shift of the concentration-response curve of the α,β-Me-ATP agonist, and shares the binding site with AF-353 (HY-14483). P2X2/3-antagonist-1 blocks bitter taste perception in mice and abolishes their preference for plain water over bitter Quinine (HY-D0143) solution .
Cat. No.: HY-137609A
Synonyms: TNP-Guanosine 5'-triphosphate tetrasodium
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (Ki = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X2 and P2X2/3 receptors with IC50 values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (Ki = 11 nM) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
