134362-79-1
134362-79-1
Chemical Structure
Ro 0437626
- CAS. Nr.: 134362-79-1
- Formula:C27H35N5O4S
- Molecular Weight:525.66
IUPAC Name: N-((R)-1-(((2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl)amino)-1-oxo-3-(thiazol-4-yl)propan-2-yl)-1H-benzo[d]imidazole-2-carboxamide
InChIKey: JHRSGCIIDRWHCD-UARRHKHWSA-N
SMILES: O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O
Biological Activity: Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1].
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Ro 0437626 | Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM). | |||||||||||||||||||||
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