1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. Ro 0437626

Ro 0437626 

Cat. No.: HY-108673
Handling Instructions

Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).

For research use only. We do not sell to patients.

Ro 0437626 Chemical Structure

Ro 0437626 Chemical Structure

CAS No. : 134362-79-1

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Description

Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1].

IC50 & Target

IC50: 3 μM (P2X1 receptor)

In Vitro

Ro 0437626 reduces PMA-evoked Ca2+entry with 6.8 ± 4.7% of control[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rat (urethane-anaesthetized)[3]
Dosage: 1 and 10 μmol/kg
Administration: I.v.
Result: Caused a reduction in postinfusion isovolumetric contractions.
Molecular Weight

525.66

Formula

C₂₇H₃₅N₅O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Ro 0437626
Cat. No.:
HY-108673
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