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racemic isomer

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製品番号 製品名 Target 研究分野 構造式
  • HY-16950A
    (E/Z)-4-Hydroxytamoxifen
    3 Publications Verification

    Afimoxifene; 4-OHT

    		 Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite Metabolic Disease Cancer
    (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .
    (E/Z)-4-Hydroxytamoxifen
  • HY-118590
    ICRF-193
    2 Publications Verification

    		 Topoisomerase DNA/RNA Synthesis Apoptosis Fungal Infection Cardiovascular Disease Inflammation/Immunology Cancer
    ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
    ICRF-193
  • HY-N2064
    Racanisodamine
    1 Publications Verification

    		 mAChR Neurological Disease
    Racanisodamine is one of the racemic isomers of anisodamine, resembles anisodamine in pharmacological effect. Racanisodamine is a non-selective muscarinic antagonist, used as a component of eye drops for myopic control .
    Racanisodamine
  • HY-107501
    (Rac)-1-Oleoyl lysophosphatidic acid sodium

    (Rac)-1-Oleoyl-sn-glycero-3-phosphate sodium; (Rac)-1-Oleoyl-LPA sodium

    		 Drug Isomer Neurological Disease
    (Rac)-1-Oleoyl lysophosphatidic acid ((Rac)-1-Oleoyl-sn-glycero-3-phosphate) sodium is the racemic isomer of 1-Oleoyl lysophosphatidic acid sodium (HY-107614) .
    (Rac)-1-Oleoyl lysophosphatidic acid sodium
  • HY-112163A
    rel-Zotatifin

    rel-eFT226

    		 Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis Infection Cancer
    rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex .
    rel-Zotatifin
  • HY-111226A
    (E/Z)-GSK5182

    		Estrogen Receptor/ERR Reactive Oxygen Species (ROS) Cardiovascular Disease Cancer
    (E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM . GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma .
    (E/Z)-GSK5182
  • HY-135113
    DL/meso-Lanthionine

    		Amino Acid Derivatives Others
    DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.
    DL/meso-Lanthionine
  • HY-102094
    (E/Z)-SIB-1893

    		mGluR Neurological Disease
    (E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist .
    (E/Z)-SIB-1893
  • HY-119961
    (+)-Mepivacaine

    Dexivacaine; (S)-Mepivacaine

    		 Sodium Channel Cardiovascular Disease
    (+)-Mepivacaine is a racemic isomer of Mepivacaine (HY-B0517), which has analgesic and vasoconstrictive activity. Mepivacaine is an amide type agent that temporarily causes local loss of consciousness. Mepivacaine binds to specific voltage-gated sodium channels on neuronal cell membranes, inhibiting sodium influx and membrane depolarization .
    (+)-Mepivacaine
  • HY-B0267C
    (R)-Oxybutynin

    Aroxybutynin

    		 mAChR Neurological Disease
    (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction .
    (R)-Oxybutynin
  • HY-112149A
    (E/Z)-ZL0420

    		Epigenetic Reader Domain Inflammation/Immunology Cancer
    (E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 .
    (E/Z)-ZL0420
  • HY-B0203B
    (Rac)-Nebivolol

    (Rac)-R 065824

    		 Adrenergic Receptor NADPH Oxidase Cardiovascular Disease
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
    (Rac)-Nebivolol
  • HY-126144A
    (E/Z)-GSK-3β inhibitor 1

    		GSK-3 Metabolic Disease
    (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM .
    (E/Z)-GSK-3β inhibitor 1
  • HY-138794A
    (Rac)-XL177A

    		Deubiquitinase Cancer
    (Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
    (Rac)-XL177A
  • HY-14735
    Arbaclofen placarbil

    XP 19986

    		 GABA Receptor Neurological Disease
    Arbaclofen placarbil is a novel transported proagent of the active R-isomer of baclofen. Baclofen is a racemic GABAB receptor agonist
    Arbaclofen placarbil
  • HY-W295313
    (+)-Neoisomenthol

    		Drug Derivative Others
    (+)-Neoisomenthol is one of the isomers of (±)-Neoisomenthol. (±)-Neoisomenthol is a compound that belongs to the class of monoterpenes. (±)-Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. It is a chiral compound, existing as a racemic mixture of two enantiomers, (+)-neoisomenthol and (-)-neoisomenthol.
    (+)-Neoisomenthol
  • HY-106601A
    Picenadol hydrochloride

    LY-150720 hydrochloride

    		 Opioid Receptor Neurological Disease
    Picenadol (LY-150720) hydrochloride is an opioid mixed agonist-antagonist analgesic. Picenadol hydrochloride is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol hydrochloride has anticholinergic activity .
    Picenadol hydrochloride
  • HY-107459
    (E/Z)-AG490
    1 Publications Verification

    (E/Z)-Tyrphostin AG490; (E/Z)-Tyrphostin B42

    		 EGFR STAT JAK Cancer
    (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
    (E/Z)-AG490
  • HY-120723
    (Rac)-Phox-I1

    		Reactive Oxygen Species (ROS) Others
    (Rac)-Phox-I1 is a racemic isomer of Phox-I1. Phox-I1 is a p67 phox inhibitor. Phox-I1 inhibits ROS production .
    (Rac)-Phox-I1
  • HY-118590A
    ICRF-196

    		Topoisomerase DNA/RNA Synthesis Apoptosis Fungal Infection Cardiovascular Disease Inflammation/Immunology Cancer
    ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is a DNA Topoisomerase II inhibitor. ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .
    ICRF-196
  • HY-16950AR
    (E/Z)-4-Hydroxytamoxifen (Standard)

    Afimoxifene (Standard); 4-OHT (Standard)

    		 Reference Standards Estrogen Receptor/ERR Endogenous Metabolite Cancer
    (E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .
    (E/Z)-4-Hydroxytamoxifen (Standard)
  • HY-B0203BS2
    (Rac)-Nebivolol-d2,15N

    (Rac)-R 065824-d2,15N

    		 NADPH Oxidase Adrenergic Receptor Isotope-Labeled Compounds Cardiovascular Disease
    (Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
    (Rac)-Nebivolol-d2,15N
  • HY-12993A
    RSV604 racemate

    A-60444 racemate

    		 RSV Others
    RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
    RSV604 racemate
  • HY-N2064R
    Racanisodamine (Standard)

    		Reference Standards mAChR Neurological Disease
    Racanisodamine is one of the racemic isomers of anisodamine, resembles anisodamine in pharmacological effect. Racanisodamine is a non-selective muscarinic antagonist, used as a component of eye drops for myopic control .
    Racanisodamine (Standard)
  • HY-115441
    (Rac)-Luliconazole

    (Rac)-NND 502

    		 Antibiotic Fungal Infection
    (Rac)-Luliconazole ((Rac)-NND 502) is the racemic isomer of Luliconazole (HY-14283). Luliconazole is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity .
    (Rac)-Luliconazole
  • HY-176106
    1-Naphthyl U-47700

    		Opioid Receptor Others
    1-Naphthyl U-47700 is an α-isomer. 1-Naphthyl U-47700 is a racemic mixtures of the trans-isomers [R,R and S,S]. 1-Naphthyl U-47700 activates MOR in a concentration-dependent manner (EC50 > 23 μM) .
    1-Naphthyl U-47700
  • HY-W008914
    (E/Z)-CP-724714

    		EGFR Cancer
    (E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent and selective orally active ErbB2 (HER2) inhibitor .
    (E/Z)-CP-724714
  • HY-113972A
    (E/Z)-Methyl mycophenolate

    		Drug Isomer Inflammation/Immunology
    (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides .
    (E/Z)-Methyl mycophenolate
  • HY-106601
    Picenadol

    LY-150720

    		 Opioid Receptor Neurological Disease
    Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity .
    Picenadol
  • HY-126108
    (±)8-HEPE

    		Others Metabolic Disease
    (±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of (±)8-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.
    (±)8-HEPE
  • HY-B0267CS
    (R)-Oxybutynin-d10

    Aroxybutynin-d10

    		 Isotope-Labeled Compounds mAChR Neurological Disease
    (R)-Oxybutynin-d10 (Aroxybutynin-d10) is deuterium labeled (R)-Oxybutynin. (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction .
    (R)-Oxybutynin-d10
  • HY-Z7721
    (Rac)-Beraprost sodium

    (Rac)-TRK-100; (Rac)-ML 1129 sodium

    		 Prostaglandin Receptor Cardiovascular Disease
    (Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
    (Rac)-Beraprost sodium
  • HY-126072
    (Rac)-GK563

    		Drug Isomer Others
    (Rac)-GK563 is the isomer of GK563 (HY-138990). GK563 is a Ca 2+-independent group VI phospholipase A2 (GVIA iPLA2) inhibitor .
    (Rac)-GK563
  • HY-Z16647
    (-)-Neoisomenthol

    		Others Others
    (-) -Neoisomenthol is one of the isomers of (±) -Neoisomenthol. (±) -Neoisomenthol is a compound that belongs to the class of monoterpenes. (±) -Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. It is a chiral compound, existing as a racemic mixture of two enantiomers, (+) -neoisomenthol and (-) -neoisomenthol.
    (-)-Neoisomenthol
  • HY-102094R
    (E/Z)-SIB-1893 (Standard)

    		Reference Standards mGluR Neurological Disease
    (E/Z)-SIB-1893 (Standard) is the analytical standard of (E/Z)-SIB-1893 (HY-102094). This product is intended for research and analytical applications. (E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist .
    (E/Z)-SIB-1893 (Standard)
  • HY-107459R
    (E/Z)-AG490 (Standard)

    (E/Z)-Tyrphostin AG490 (Standard); (E/Z)-Tyrphostin B42 (Standard)

    		 Reference Standards EGFR STAT JAK Cancer
    (E/Z)-AG490 (Standard) is the analytical standard of (E/Z)-AG490 (HY-107459). This product is intended for research and analytical applications. (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine Kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
    (E/Z)-AG490 (Standard)
  • HY-137258A
    (R)-N-3-Benzylnirvanol

    		Drug Isomer Cytochrome P450 Metabolic Disease
    (R)-N-3-Benzylnirvanol is the R-isomer of (±)-N-3-Benzylnirvanol (HY-137258). (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively .
    (R)-N-3-Benzylnirvanol

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