55 Results for "

rheumatic

" in MedChemExpress (MCE) Product Catalog:
Products (55)

55 Results for "rheumatic" in MCE Product Catalog:

84
84 Publications Verification
Cat. No.: HY-14655
CAS No.: 599-79-1
Purity:  98.75%
Synonyms: NSC 667219; Salicylazosulfapyridine
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
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10
10 Cited Publications
Cat. No.: HY-N0847
CAS No.: 68370-47-8
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
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8
8 Cited Publications
Cat. No.: HY-B0256
CAS No.: 446-86-6
Synonyms: BW 57-322
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .
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7
7 Cited Publications
Cat. No.: HY-N0283
CAS No.: 13739-02-1
Synonyms: Diacerhein; Diacetylrhein
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .
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2
2 Cited Publications
Cat. No.: HY-B0212
CAS No.: 144-83-2
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Inflammation/Immunology

Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .
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2
2 Cited Publications
Cat. No.: HY-A0068
CAS No.: 12192-57-3
Synonyms: Gold thioglucose
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .
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1
1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .
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1
1 Cited Publications
Cat. No.: HY-106579
CAS No.: 33005-95-7
Purity:  98.74%
Target:  

COX

Research Areas:  

Inflammation/Immunology

Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases .
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1
1 Cited Publications
Cat. No.: HY-P10710A
BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis .
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1
1 Cited Publications
Cat. No.: HY-W014750
CAS No.: 779-30-6
3-Acetamidocoumarin plays an important role in biology and medicine. 3-Acetamidocoumarin has physiological effects and has been used for many diseases such as research of burns, brucellosis-rheumatic diseases and cancer .
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Cat. No.: HY-W040672
CAS No.: 1553-60-2
Synonyms: Dytransin
Target:  

COX

Research Areas:  

Inflammation/Immunology

Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
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Cat. No.: HY-17361
CAS No.: 30544-47-9
Target:  

COX

Research Areas:  

Inflammation/Immunology

Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .
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Cat. No.: HY-14655S
CAS No.: 1346606-50-5
Purity:  98.95%
Synonyms: NSC 667219-d4; Salicylazosulfapyridine-d4
Sulfasalazine-d4 is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
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Cat. No.: HY-P10710
CAS No.: 1629625-47-3
BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis .
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Cat. No.: HY-N5025
CAS No.: 1354-84-3
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .
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Cat. No.: HY-106583
CAS No.: 87234-24-0
Purity:  99.19%
Synonyms: Cinnoxicam; SPA-S-510; Sinartol
Target:  

COX

Research Areas:  

Inflammation/Immunology

Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .
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Cat. No.: HY-17475
CAS No.: 2139-47-1
Research Areas:  

Inflammation/Immunology

Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders.
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Cat. No.: HY-N0131R
CAS No.: 83-48-7
Synonyms: Stigmasterin (Standard)
Stigmasterol (Standard) is the analytical standard of Stigmasterol (HY-N0131). This product is intended for research and analytical applications. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
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Cat. No.: HY-W338346
CAS No.: 2016-36-6
Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer .
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Cat. No.: HY-B1130
CAS No.: 34552-84-6
Target:  

COX

Research Areas:  

Inflammation/Immunology

Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders .
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