Search Result

Results for "

rheumatic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Deaminase (1) Akt (2) Antibiotic (6) Antifolate (1) Apoptosis (8) Autophagy (4) Bacterial (7) Biochemical Assay Reagents (3) c-Myc (1) Calcium Channel (1) Collagen (1) COX (16) Drug Derivative (1) Endogenous Metabolite (2) ERK (1) Ferroptosis (4) HIV (1) IFNAR (2) Interleukin Related (4) Isotope-Labeled Compounds (5) JAK (2) Keap1-Nrf2 (2) MMP (4) NF-κB (10) NO Synthase (3) P2X Receptor (1) p38 MAPK (1) PI3K (2) Polo-like Kinase (PLK) (1) Reactive Oxygen Species (ROS) (2) Reference Standards (12) TGF-beta/Smad (2) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Endocrinology (1) Infection (8) Inflammation/Immunology (50) Metabolic Disease (4) Neurological Disease (6)

By Targets:

Adenosine Deaminase (1)

Akt (2)

Antibiotic (6)

Antifolate (1)

Apoptosis (8)

Autophagy (4)

Bacterial (7)

Biochemical Assay Reagents (3)

c-Myc (1)

Calcium Channel (1)

Collagen (1)

COX (16)

Drug Derivative (1)

Endogenous Metabolite (2)

ERK (1)

Ferroptosis (4)

HIV (1)

IFNAR (2)

Interleukin Related (4)

Isotope-Labeled Compounds (5)

JAK (2)

Keap1-Nrf2 (2)

MMP (4)

NF-κB (10)

NO Synthase (3)

P2X Receptor (1)

p38 MAPK (1)

PI3K (2)

Polo-like Kinase (PLK) (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (12)

TGF-beta/Smad (2)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (8)

Inflammation/Immunology (50)

Metabolic Disease (4)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14655

Sulfasalazine Maximum Cited Publications 78 Publications Verification NSC 667219	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-B0256

Azathioprine 5+ Cited Publications BW 57-322	Apoptosis	Inflammation/Immunology Cancer
Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-N0283

Diacerein 5+ Cited Publications Diacerhein; Diacetylrhein	Interleukin Related Calcium Channel	Inflammation/Immunology
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-N0847

Micheliolide 5+ Cited Publications	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N0807

Swertiamarin 1 Publications Verification	MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

HY-W040672

Ibufenac Dytransin	COX	Inflammation/Immunology
Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-B0212

Sulfapyridine 2 Publications Verification	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits *recombinant P. carinii* dihydropteroate synthetase (DHPS) with an IC₅₀** of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-A0068

Aurothioglucose 2 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-17361

Etofenamate	COX	Inflammation/Immunology
Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-106579

Tiaprofenic acid 1 Publications Verification	COX	Inflammation/Immunology
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases .

HY-14655S

Sulfasalazine-d4	Isotope-Labeled Compounds NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-P10710

BMP-4 (15-24)	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) can be used in the research of arthritis .

HY-N5025

Bullatine A	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

HY-106583

Piroxicam cinnamate Cinnoxicam; SPA-S-510; Sinartol	COX	Inflammation/Immunology
Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .

HY-17475

Nifenazone	Biochemical Assay Reagents	Inflammation/Immunology
Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders.

HY-P10710A

BMP-4 (15-24) acetate 1 Publications Verification	IFNAR Interleukin Related COX NO Synthase	Inflammation/Immunology
BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis .

HY-N0131R

Stigmasterol (Standard) Maximum Cited Publications 13 Publications Verification Stigmasterin (Standard)	Reference Standards MMP Endogenous Metabolite	Inflammation/Immunology
Stigmasterol (Standard) is the analytical standard of Stigmasterol (HY-N0131). This product is intended for research and analytical applications. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

HY-W338346

Salicylate choline	Drug Derivative Interleukin Related TNF Receptor Polo-like Kinase (PLK)	Inflammation/Immunology Cancer
Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer .

HY-B1130

Isoxicam	COX	Inflammation/Immunology
Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders .

HY-B0212R

Sulfapyridine (Standard)	Reference Standards Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits *recombinant P. carinii* dihydropteroate synthetase (DHPS) with an IC₅₀** of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-B0256R

Azathioprine (Standard) BW 57-322 (Standard)	Reference Standards Apoptosis	Inflammation/Immunology Cancer
Azathioprine (Standard) is the analytical standard of Azathioprine. This product is intended for research and analytical applications. Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-B1130R

Isoxicam (Standard)	Reference Standards COX	Inflammation/Immunology
Isoxicam (Standard) is the analytical standard of Isoxicam (HY-B1130). This product is intended for research and analytical applications. Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders .

HY-145455

Salazopyridazine	Bacterial	Infection
Salazopyridazine is an antibacterial agent. Salazopyridazine shows activities against ulcerative colitis. Salazopyridazine can be used for the research of rheumatic diseases .

HY-W014750

3-Acetamidocoumarin 1 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology Cancer
3-Acetamidocoumarin plays an important role in biology and medicine. 3-Acetamidocoumarin has physiological effects and has been used for many diseases such as research of burns, brucellosis-rheumatic diseases and cancer .

HY-14750

Rabeximod ROB-803	Toll-like Receptor (TLR)	Neurological Disease Inflammation/Immunology
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research .

HY-127150

Clofezone Perclusone	Collagen	Inflammation/Immunology
Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS) .

HY-N4030

Humantenmine Gelsenicine	Others	Inflammation/Immunology
Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment .

HY-151241

Sinomenine N-oxide (+)-Sinomenine N-oxide	NO Synthase	Inflammation/Immunology
Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC₅₀ value of 23.04 μM .

HY-14655R

Sulfasalazine (Standard) NSC 667219 (Standard)	Reference Standards NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine (Standard) is the analytical standard of Sulfasalazine. This product is intended for research and analytical applications. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-106579S

Tiaprofenic acid-d3	COX	Inflammation/Immunology
Tiaprofenic acid-d₃ is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases .

HY-N1006

10-Hydroxyscandine	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
10-Hydroxyscandine is an alkaloid from Melodinus tenuicaudatus. 10-Hydroxyscandine can be used for the research of hernia, dyspepsia, abdominal pain, and rheumatic heart .

HY-E70233

Histidyl-tRNA synthetase, human	Others	Inflammation/Immunology
Histidyl-tRNA synthetase, human is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. Histidyl-tRNA synthetase has been found to act as a particularly important antigen in autoimmune diseases such as rheumatic arthritis or myositis .

HY-105630

Pipebuzone LD-4644	Others	Inflammation/Immunology
Pipebuzone (LD 4644) is an anti-inflammatory, antipyretic and analgesic agent. Pipebuzone plays an important raol in rheumatic diseases .

HY-N0847R

Micheliolide (Standard)	Reference Standards NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-122154

FR234938	Adenosine Deaminase	Inflammation/Immunology
FR234938 is a non-nucleoside adenosine deaminase inhibitor with an IC₅₀ of 17 nM for recombinant human adenosine deaminase enzyme. FR234938 has anti-rheumatic and anti-inflammatory effects .

HY-W040672R

Ibufenac (Standard) Dytransin (Standard)	Reference Standards COX	Inflammation/Immunology
Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-N0131S1

Stigmasterol-d5-1 Stigmasterin-d₅-1	Isotope-Labeled Compounds MMP Endogenous Metabolite	Inflammation/Immunology
Stigmasterol-d₅-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases .

HY-N0807R

Swertiamarin (Standard)	Reference Standards MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin (Standard) is the analytical standard of Swertiamarin. This product is intended for research and analytical applications. Swertiamarin is an orally active iridoid compound with hypoglycemic, hypolipidemic, anti rheumatic and antioxidant activities, which can be used in the research of diabetes and arthritis .

HY-106579R

Tiaprofenic acid (Standard)	Reference Standards COX	Inflammation/Immunology
Tiaprofenic acid (Standard) is the analytical standard of Tiaprofenic acid. This product is intended for research and analytical applications. Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases .

HY-17361S

Etofenamate-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Etofenamate-d₄ is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-14655S1

Sulfasalazine-d3,15N NSC 667219-d₃,¹⁵N	Antibiotic Autophagy NF-κB Apoptosis Bacterial Ferroptosis Isotope-Labeled Compounds	Infection Inflammation/Immunology Cancer
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-17361R

Etofenamate (Standard)	Reference Standards COX	Inflammation/Immunology
Etofenamate (Standard) is the analytical standard of Etofenamate. This product is intended for research and analytical applications. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-105028A

Tenidap sodium CP-66248 sodium	COX	Inflammation/Immunology
Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC₅₀ values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3 .

HY-W756637

Ibufenac-13C6 Dytransin-¹³C₆	Isotope-Labeled Compounds COX	Inflammation/Immunology
Ibufenac-13C6 (Dytransin-13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-B0256A

Azathioprine sodium BW 57-322 sodium	Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .

HY-19242

MX-68	Antifolate	Inflammation/Immunology
MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis .

HY-N9602

6,7,4'-Trihydroxyflavanone	Others	Inflammation/Immunology
6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells .

HY-106583R

Piroxicam cinnamate (Standard) Cinnoxicam (Standard); SPA-S-510 (Standard); Sinartol (Standard)	Reference Standards COX	Inflammation/Immunology
Piroxicam cinnamate (Standard) is the analytical standard of Piroxicam cinnamate (HY-106583). This product is intended for research and analytical applications. Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research .

HY-N7002

Nagarine 10-Hydroxy aconitine	Others	Neurological Disease Inflammation/Immunology
Nagarine, an alkaloid isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), is used to treat Rheumatic and neuralgic disorders .

HY-N18761

Willow bark extract	Others	Neurological Disease Inflammation/Immunology
Willow Bark Extract is derived from the branch or bark extract of weeping willow of the Salix family. It has antipyretic, analgesic, anti-inflammatory, and anti-rheumatic effects.

Cat. No.	Product Name

HY-L210

Anti-Rheumatic Arthritis Compound Library

1,883 compounds

Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA).

MCE has collected 1,883 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.

HY-L191

Tibetan Medicine Compound Library

1,136 compounds

Tibetan medicine, as one of the treasures of traditional Chinese medicine, carries the profound cultural heritage of the Tibetan people and their unique understanding of health. Tibet is the birthplace of Tibetan medicine, and its plateau climate and unique ecological environment have nurtured its rich medicinal resources. Among them, cordyceps, saffron and snow lily are favored by people for their excellent medicinal value and unique growth characteristics. Tibetan medicine, with its profound heritage, plays a crucial role in the management of diseases that are unique to high-altitude regions, such as altitude stress. It facilitates a swifter adaptation to high-altitude conditions and mitigates the symptoms of altitude sickness by meticulously recalibrating the internal environment within the human body. For rheumatic diseases, cardiovascular diseases, etc., Tibetan medicine has also shown its remarkable effect.

MCE included 1,136 natural products from Tibetan medicine, including animal, plant and mineral sources.

HY-L046

Anti-Cardiovascular Disease Compound Library

2,282 compounds

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk.

MCE supplies a unique collection of 2,282 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Cat. No.	Product Name	Target	Research Area