144-83-2
144-83-2
Chemical Structure
Sulfapyridine
- CAS No.: 144-83-2
- Formula:C11H11N3O2S
- Molecular Weight:249.29
IUPAC Name: 4-amino-N-(pyridin-2-yl)benzenesulfonamide
InChIKey: GECHUMIMRBOMGK-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=C2)=O
Biological Activity: Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sulfapyridine | 99.85% | Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities. | ||||||||||||||||||||
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Sulfapyridine (Standard) | 99.86% | Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities. | ||||||||||||||||||||
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Sulfapyridine-d4 | 99.35% | Sulfapyridine-d4 is the deuterated-labeled Sulfapyridine (HY-B0212). Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities. | ||||||||||||||||||||
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Sulfaclozine | 99.0% | Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis). | ||||||||||||||||||||
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Sulfadiazine 100 µg/mL in methanol | Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection. | |||||||||||||||||||||
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Sulfadiazine-13C6 | 99.18% | Sulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is an orally active sulfonamide antibiotic. Sulfadiazine competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine targets Toxoplasma gondii DHPS enzyme. Sulfadiazine can be used for the research of congenital toxoplasmosis and bacterial infection. | ||||||||||||||||||||
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Sulfathiazole (100 µg/mL in acetonitrile) | Sulfathiazole (100 μg/mL in acetonitrile) is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole (100 μg/mL in acetonitrile) increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole (100 μg/mL in acetonitrile) is also a cathodic corrosion inhibitor. Sulfathiazole (100 μg/mL in acetonitrile) inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively. | |||||||||||||||||||||
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Sulfamerazine (Standard) | 99.72% | Sulfamerazine (Standard) is the analytical standard of Sulfamerazine. This product is intended for research and analytical applications. Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection. | ||||||||||||||||||||
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Sulfamerazine-13C6 | 99.11% | Sulfamerazine-13C6 (RP2632-13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection. | ||||||||||||||||||||
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Sulfaquinoxaline (Standard) | ≥98% | Sulfaquinoxaline (Standard) is the analytical standard of Sulfaquinoxaline. This product is intended for research and analytical applications. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections. | ||||||||||||||||||||
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Sulfachloropyridazine | 99.51% | Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters. | ||||||||||||||||||||
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Sulfachloropyridazine-13C6 | Sulfachloropyridazine-13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria. | |||||||||||||||||||||
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Sulfabenz | Sulfabenz (Compound 9) is an amine-substituted N1-phenylsulfonyl indole derivative. Sulfabenz has binding activity to human 5-HT6 serotonin receptor (Ki: 200 nM). Sulfabenz can be used to study the ligand binding mechanism of 5-HT6 receptor and 5-HT6 receptor-related neurological diseases. | |||||||||||||||||||||
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References
- [1]. Kazuki Omoteyama, et al. Effects of salazosulfapyridine on the profile of cell surface proteins, revealed by biotinylation of cell surface proteins and 2-dimentional electrophoresis. Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867(1):47-56. [Content Brief]
- [2]. J J Andreasen, et al. In vitro susceptibility of diarrhoea producing gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones. Brief report. APMIS. 1988 Jun;96(6):568-70. [Content Brief]
- [3]. Y L Hong, et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. [Content Brief]
