34552-84-6
Chemical Structure
Isoxicam
- CAS No.: 34552-84-6
- Formula:C14H13N3O5S
- Molecular Weight:335.34
IUPAC Name: 4-hydroxy-2-methyl-N-(5-methylisoxazol-3-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide
InChIKey: YYUAYBYLJSNDCX-UHFFFAOYSA-N
SMILES: O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NOC(C)=C3
Biological Activity: Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders[1][2].
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Isoxicam | 99.83% | Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders. | ||||||||||||||||||||
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Isoxicam (Standard) | 99.58% | Isoxicam (Standard) is the analytical standard of Isoxicam (HY-B1130). This product is intended for research and analytical applications. Isoxicam is an orally active nonsteroidal anti-inflammatory compound and a COX-1/COX-2 inhibitor. Isoxicam exhibits potent anti-inflammatory activity in rat models of inflammation and significantly lower ulcerogenic risk. Isoxicam can be used for the study of inflammatory diseases and rheumatic disorders. | ||||||||||||||||||||
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- [1]. Xu S, et al. Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J Biol Chem. 2014;289(10):6799-6808.
- [2]. DiPasquale G, et al. The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide). Agents Actions. 1975;5(3):256-263. [Content Brief]
Keywords
