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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
six-membered rings
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "six-membered rings" in MCE Product Catalog:
49
49 Cited Publications
Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
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Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .
Cat. No.: HY-15917S2
CAS No.: 850153-85-4
Synonyms: DTT-d6
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2-Coumaranone is a bicyclic heteroaromatic compound in which a six-membered benzene ring is annulated with a five-membered γ-butyrolactone ring. 2-Coumaranone can be used to synthesize chemiluminescent and fluorescent dyes .
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DTBT is a six-membered heterocyclic ring that is commonly used in the preparation of organic electronic devices, such as P-type organic semiconductors (OFETs) and P-type organic photodiodes (OLEDs). DTBT has good performance in electron transmission and photoelectric conversion. DTBT polymerizes to form donor-acceptor polymers, which are used to prepare solar cells .
Synonyms: Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride
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Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .
Cat. No.: HY-15917S
CAS No.: 302912-05-6
Synonyms: DTT-d10
Synonyms: Bonomycin (Standard); 6-Demethyl-6-deoxytetracycline (Standard)
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Sancycline (Standard) is the analytical standard of Sancycline. This product is intended for research and analytical applications. Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
Cat. No.: HY-15917S1
CAS No.: 203633-21-0
Synonyms: DTTl-d10-1
Cat. No.: HY-E71129
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The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. (S)-Norcoclaurine synthase (EC 3.5.99.14) , formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl) benzene-1,2-diol + (3,4-dihydroxyphenyl) acetaldehyde to form (S)-norlaudanosoline.
Cat. No.: HY-N20714
CAS No.: 197449-09-5
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Cat. No.: HY-L950
2,787 compounds
Seven-membered rings are privileged medium-sized scaffolds with distinct twist-chair conformations and greater 3D diversity than five- and six-membered rings. Their flexible conformations allow induced-fit protein binding and precise pharmacophore positioning. They also modulate Fsp³, pKa and logP to enhance solubility and permeability. Azepanes, oxepanes and benzodiazepines serve as bioisosteres for hit discovery against GPCRs, ion channels and kinases.
Widely found in plant and microbial alkaloids, seven-membered heterocycles show excellent biocompatibility and target affinity. They underpin many approved drugs for CNS, cancer and infectious diseases, including diazepam, imipramine and carbamazepine. Clinical candidates further highlight their unique value. However, high transannular strain and synthetic difficulty limit their availability, leaving them rare in standard screening libraries.
MCE 7 Membered Scaffold Library contains 2,792 structurally diverse, lead-like molecules covering azepanes, oxepanes, benzodiazepines and dibenzazepines. With varied substitutions, chiral centers and synthetic accessibility, it fills the shortage of medium-ring scaffolds. Ideal for HTS, virtual screening and SAR studies, these novel, patent-clear compounds offer a distinctive starting point for drug discovery in CNS disorders, oncology, antivirals and challenging targets such as PPIs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
