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skin

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1163

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4

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18

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84

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159

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1

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19

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275

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67

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8

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4

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18

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3

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145191
    MrgprX2 antagonist-1
    5 Publications Verification

    		 Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-1 is an MrgprX2 antagonist extracted from patent WO2021092264A1, example E23. MrgprX2 antagonist-1 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-1
  • HY-145192
    MrgprX2 antagonist-2

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-2 is an MrgprX2 antagonist extracted from patent WO2021092262A1, example E163. MrgprX2 antagonist-2 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-2
  • HY-145193
    MrgprX2 antagonist-3

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-3 is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E117. MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-3
  • HY-Y1365L
    Porcine skin Gelatin,suitable for cell culture(high gel strength)

    		Biochemical Assay Reagents Others
    Porcine skin Gelatin,suitable for cell culture(high gel strength) can be used to coat cells to improve cell attachment .
    Porcine skin Gelatin,suitable for cell culture(high gel strength)
  • HY-141582
    Ceramide 3

    N-Stearoyl phytosphingosine

    		 JNK NF-κB Interleukin Related TNF Receptor Inflammation/Immunology
    Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .
    Ceramide 3
  • HY-P0097
    Nonapeptide-1
    2 Publications Verification

    Melanostatine-5

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1
  • HY-13102
    UK-383367

    		Procollagen C Proteinase Others
    UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring .
    UK-383367
  • HY-145195
    MrgprX2 antagonist-5

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-5
  • HY-NP175
    Collagen (bovine skin)

    		Biochemical Assay Reagents Integrin Discoidin Domain Receptor Others
    Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development .
    Collagen (bovine skin)
  • HY-W010056
    Diethyl fumarate
    1 Publications Verification

    		 NOD-like Receptor (NLR) Neurological Disease Inflammation/Immunology
    Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin (HY-N0005) hybridize to exert neuroprotective effects .
    Diethyl fumarate
  • HY-112959
    Telavancin

    TD-6424

    		 Antibiotic Bacterial Infection
    Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria .
    Telavancin
  • HY-P0095
    Acetyl tetrapeptide-5

    		Angiotensin-converting Enzyme (ACE) Others
    Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .
    Acetyl tetrapeptide-5
  • HY-W015300
    Suberic acid

    Octanedioic acid

    		 Endogenous Metabolite Akt TGF-β Receptor p38 MAPK Metabolic Disease
    Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness .
    Suberic acid
  • HY-124190
    Isopropyl myristate

    		Environmental Pollutants Biochemical Assay Reagents Others
    Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate is used for transdermal delivery of some compounds. Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired .
    Isopropyl myristate
  • HY-130187A
    Sapienic acid sodium
    1 Publications Verification

    		 Bacterial Infection
    Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .
    Sapienic acid sodium
  • HY-N7132
    (-)-Menthyl acetate

    L-Menthyl acetate

    		 Biochemical Assay Reagents Drug Derivative Others
    (-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .
    (-)-Menthyl acetate
  • HY-145194
    MrgprX2 antagonist-4

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-4 is an MrgprX2 antagonist extracted from patent US20210128561A1, compound B-51 E117. MrgprX2 antagonist-4 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-4
  • HY-B1695
    Methyl nicotinate

    Nicotinic acid methyl ester

    		 Others Cardiovascular Disease Inflammation/Immunology
    Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .
    Methyl nicotinate
  • HY-Y1365E
    Porcine skin Gelatin,suitable for cell culture(medium gel strength)

    		Biochemical Assay Reagents Others
    Porcine skin Gelatin, suitable for cell culture (medium gel strength) can be used to coat cells to improve cell attachment .
    Porcine skin Gelatin,suitable for cell culture(medium gel strength)
  • HY-P0104
    Palmitoyl tripeptide-38

    		Collagen Metabolic Disease
    Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone) .
    Palmitoyl tripeptide-38
  • HY-U00058
    Diflucortolone valerate

    		Fungal Bacterial Infection Inflammation/Immunology
    Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .
    Diflucortolone valerate
  • HY-P3452
    Tetrapeptide-30

    		Tyrosinase Inflammation/Immunology
    Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .
    Tetrapeptide-30
  • HY-B1365
    Prednicarbate

    		Glucocorticoid Receptor Inflammation/Immunology
    Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis .
    Prednicarbate
  • HY-W040996R
    2-Octyldodecanol (Standard)

    		Biochemical Assay Reagents Reference Standards Others
    2-Octyldodecanol (Standard) is the analytical standard of 2-Octyldodecanol. This product is intended for research and analytical applications. 2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .
    2-Octyldodecanol (Standard)
  • HY-145955
    Stearoyl glutamic acid sodium

    Sodium stearoyl glutamate

    		 Biochemical Assay Reagents Others
    Sodium stearoyl glutamate is a sodium salt of monocarboxylic acid anionic surfactant, which serves as a chelating agent, skin sensitizer and anionic co-emulsifier .
    Stearoyl glutamic acid sodium
  • HY-P0097A
    Nonapeptide-1 acetate salt
    2 Publications Verification

    Melanostatine-5 acetate salt

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1 acetate salt
  • HY-N10496
    Sericoside

    		Others Inflammation/Immunology
    Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .
    Sericoside
  • HY-W040996
    2-Octyldodecanol

    		Environmental Pollutants Others
    2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .
    2-Octyldodecanol
  • HY-14737A
    Ceftaroline fosamil hydrate
    2 Publications Verification

    TAK-599 hydrate; PPI0903 hydrate

    		 Antibiotic Bacterial Infection
    Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) .
    Ceftaroline fosamil hydrate
  • HY-125407
    Palmitoyl serinol

    N-Palmitoyl serinol

    		 Cannabinoid Receptor Inflammation/Immunology
    Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin .
    Palmitoyl serinol
  • HY-118157
    3,5,7-Trimethoxyflavone

    		MMP Inflammation/Immunology
    3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .
    3,5,7-Trimethoxyflavone
  • HY-P4848
    Dermcidin-1L (human)

    		Antibiotic Infection
    Dermcidin-1L (human) is an antibiotic peptide secreted by sweat glands. Dermcidin-1L (human) has antimicrobial activity. Dermcidin-1L (human) can be used for the research of inflammatory skin disorders .
    Dermcidin-1L (human)
  • HY-NP101
    Highly purified Type I collagen, from bovine skin
    1 Publications Verification

    Bovine Type I collagen, immunization grade

    		 Biochemical Assay Reagents Inflammation/Immunology
    Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .
    Highly purified Type I collagen, from bovine skin
  • HY-NP109
    Highly purified type I collagen, from mouse skin

    Mouse Type I collagen, immunization grade

    		 MMP Inflammation/Immunology
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified type I collagen, from mouse skin
  • HY-P5237
    Tetrapeptide-4

    		Collagen Others
    Tetrapeptide-4 is a synthetic tetrapeptide. Tetrapeptide-4 upregulates hyaluronic acid synthetase, and collagen production in human dermal fibroblasts. Tetrapeptide-4 reduces skin aging, improves skin firmness, elasticity, and appearance, and benefits hair .
    Tetrapeptide-4
  • HY-132818
    Idrevloride

    P-1037

    		 Sodium Channel Others
    Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .
    Idrevloride
  • HY-P3915
    Esculentin 1A

    		Bacterial Infection
    Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .
    Esculentin 1A
  • HY-W250145
    Acid Black 2

    Nigrosine

    		 Biochemical Assay Reagents Others
    Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin .
    Acid Black 2
  • HY-130187
    Sapienic acid
    1 Publications Verification

    		 Bacterial Infection
    Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .
    Sapienic acid
  • HY-133027
    Myristyl nicotinate

    Tetradecyl nicotinate

    		 Biochemical Assay Reagents Cancer
    Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .
    Myristyl nicotinate
  • HY-W009051
    Decamethylcyclopentasiloxane

    		Environmental Pollutants Biochemical Assay Reagents Others
    Decamethylcyclopentasiloxane (D5), an organosilicon compound that is used as a skin emollient in cosmetics and personal products .
    Decamethylcyclopentasiloxane
  • HY-164066
    Sodium Acetylated Hyaluronate

    		Biochemical Assay Reagents Others
    Sodium Acetylated Hyaluronate is an acetylated hyaluronic acid derivative with anti-wrinkle and deep skin penetration properties, which can be used in skin aging research and cosmetic development .
    Sodium Acetylated Hyaluronate
  • HY-W591838
    Perfluoropentanesulfonic acid

    PFPeS

    		 Biochemical Assay Reagents Phosphatase Metabolic Disease
    Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin .
    Perfluoropentanesulfonic acid
  • HY-112809
    GSK2646264

    		Syk Src LRRK2 GSK-3 JAK VEGFR Aurora Kinase Inflammation/Immunology
    GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin .
    GSK2646264
  • HY-30272R
    Monobenzone (Standard)

    		DNA/RNA Synthesis Apoptosis Reference Standards Inflammation/Immunology
    Monobenzone (Standard) is the analytical standard of Monobenzone. This product is intended for research and analytical applications. Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research .
    Monobenzone (Standard)
  • HY-N2466A
    Melanotan I acetate
    1 Publications Verification

    MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate

    		 Melanocortin Receptor Cancer
    Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .
    Melanotan I acetate
  • HY-NP103
    Highly purified Type III collagen, from bovine skin

    Bovine Type III collagen, immunization grade

    		 MMP Inflammation/Immunology
    Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type III collagen, from bovine skin
  • HY-Y1356
    2,4-Dimethoxybenzaldehyde

    		Biochemical Assay Reagents Cancer
    2,4-Dimethoxybenzaldehyde is a tumor initiator with genotoxic property. 2,4-Dimethoxybenzaldehyde can induce benign papilloma development and converse to squamous cell carcinoma in the skin of susceptible mouse models. 2,4-Dimethoxybenzaldehyde can be used for skin cancer research .
    2,4-Dimethoxybenzaldehyde
  • HY-121069
    Elubiol

    Dichlorophenyl imidazoldioxolan

    		 Fungal Others
    Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff .
    Elubiol
  • HY-106647
    Abacavir hydroxyacetate

    		Interleukin Related Inflammation/Immunology
    Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems .
    Abacavir hydroxyacetate

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