α-Tocopherol phosphate disodium
Based on 8 publication(s) in Google Scholar
α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 60934-46-5
- Formula: C29H49Na2O5P
- Molecular Weight:554.65
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) α-Tocopherol phosphate disodium
More- Cell Death Dis. 2022 Jan 21;13(1):73. [Abstract]
- Cell Death Discov. 2025 Aug 22;11(1):398. [Abstract]
- Appl Mater Today. 2021, 101066.
- Cancer Cell Int. 2025 Dec 10. [Abstract]
- Pharmacol Res Perspect. 2026 Feb;14(1):e70213. [Abstract]
- bioRxiv. 2025 Sep 9:2025.09.04.674327. [Abstract]
- Research Square Preprint. 2024 Dec 29.
- Nigerian Journal of Scientific Research. 18 (3): 2019.
Biological Activity
α-Tocopherol phosphate disodium (100 μM, 24 h) inhibits high Glucose (HY-B0389)/ischemic-induced apoptosis and migration in endothelial progenitor cells, promotes capillary-like tube formation through regulation of Bcl-2, Akt, NF-κB, p38MAPK and JNK expressions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Endothelial progenitor cells derived from rat bone marrow
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Concentration:100 μM
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Incubation Time:24 h
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Result:Upregulated the expression of Bcl-2 and Akt.
Downregulated the expression of Tie2, Notch1, p38MAPK and JNK.
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Cell Line:Endothelial progenitor cells derived from rat bone marrow
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Concentration:100 μM
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Incubation Time:24 h
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Result:Promoted the cell migration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats type 2 diabetes and ischemia models[2]
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Dosage:100 μM α-Tocopherol phosphate disodium incubated with EPCs
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Administration:24 incubation, intramuscular injection of EPC into rats hind limbs
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Result:Increased the capillary density of the ischemic hindlimbs.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 60934-46-5
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Appearance Solid
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Molecular Weight 554.65
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Formula C29H49Na2O5P
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Color White to off-white
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SMILES
CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OP(O[Na])(O[Na])=O)=C1C)C
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Synonyms
alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (8)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner. [Abstract]2022 Jan 21;13(1):73. PMID: 35064112 -
Cell Death Discov
ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer. [Abstract]2025 Aug 22;11(1):398. PMID: 40846695 -
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Cancer Cell Int
Polysaccharides from Huaier induce autophagy-dependent ferroptosis to inhibit breast cancer stem cells in triple-negative breast cancer. [Abstract]2025 Dec 10. PMID: 41372887 -
Pharmacol Res Perspect
2026 Feb;14(1):e70213. PMID: 41445272 -
bioRxiv
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy. [Abstract]2025 Sep 9:2025.09.04.674327. PMID: 40964317 -
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Solvent & Solubility
DMSO : 4 mg/mL (7.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400. [Content Brief]
[2]. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8029 mL | 9.0147 mL | 18.0294 mL | 45.0735 mL |
| 5 mM | 0.3606 mL | 1.8029 mL | 3.6059 mL | 9.0147 mL |
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