Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
terminal transferase
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "terminal transferase" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
1
1 Cited Publications
Research Areas:
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
1
1 Cited Publications
Cat. No.: HY-D1668
Cat. No.: HY-150145A
Purity: 99.26%
Cat. No.: HY-158712
Purity: ≥98.0%
Cat. No.: HY-D1725
Cat. No.: HY-150145
Synonyms: Spacer Phosphoramidite 18
Target:
Research Areas:
Hexaethylene glycol phosphoramidite (Spacer Phosphoramidite 18) is an amide reagent used for oligonucleotide synthesis. Hexaethylene glycol phosphoramidite serves as a linker for the synthesis of nucleotide chains and qPCR probes .
Cat. No.: HY-D1721
Target:
Research Areas:
Fluorescein-12-dATP is a fluorescein-labeled deoxyadenosine triphosphate and signal amplifier. Fluorescein-12-dATP can be incorporated into the 3'-end of exposed thrombin-binding aptamers via terminal deoxynucleotidyl transferase to form multi-labeled nucleic acid chains, which are used for signal amplification in thrombin detection. Fluorescein-12-dATP acts as a fluorescent detection probe in chip-based aptamer sandwich biosensors for the detection of thrombin in serum. Fluorescein-12-dATP can be used in studies related to thrombin detection .
Cat. No.: HY-160841
CAS No.: 2567941-52-8
Target:
Research Areas:
Biotin-16-dCTP is a biotinylated deoxycytidine triphosphate that serves as an important DNA labeling substrate. Biotin-16-dCTP can be enzymatically incorporated into the 3' end of DNA probes via terminal deoxynucleotidyl transferase, forming a 1-3 nucleotide-long tail to achieve biotinylation of the probes. Biotin-16-dCTP enhances chemiluminescent detection of low-abundance targets such as specific tRNA isoacceptors through Northern blotting. Biotin-16-dCTP can also replace conventional dCTP to be integrated into single-stranded DNA generated by asymmetric polymerase chain reaction, which is applicable for bioconjugation or pull-down assays. Repeated freeze-thaw cycles of Biotin-16-dCTP should be avoided to prevent degradation of its function for probe biotinylation .
Cat. No.: HY-118916
CAS No.: 251577-09-0
Target:
Research Areas:
FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively .
Cat. No.: HY-118916A
CAS No.: 817586-01-9
Target:
Research Areas:
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively .
Cat. No.: HY-174849
Target:
Research Areas:
TdT-IN-1 (Compound 8c) is a selective and non-nucleoside terminal deoxynucleotidyl transferase (TdT) inhibitor with IC50 s of 0.11 and 0.19 μM for Mg 2+ and Mn 2+. TdT-IN-1 can be used for leukaemias and skin cancer research .
Cat. No.: HY-E70904
Target:
Research Areas:
Terminal Transferase, Calf (EC 2.7.7.31) is a template independent polymerase that catalyzes the addition of deoxynucleotides to the 3' hydroxyl terminus of DNA molecules. Protruding, recessed or blunt-ended double or single-stranded DNA molecules serve as a substrate for Terminal Transferase. Terminal Transferase does not have 5' or 3' exonuclease activity. The addition of Co 2+ in the reacton makes tailing more efficient.
Cat. No.: HY-P71070
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DNTT; terminal transferase; DNA Nucleotidylexotransferase; Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase; TDT; terminal Deoxyribonucleotidyltransferase; terminal Deoxynucleotidyltransferase; Deoxynucleotidyltransferase, terminal; terminal Addi
Species:
Human
Source:
E. coli
Cat. No.: HY-P78946
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DNTT; terminal transferase; DNA Nucleotidylexotransferase; Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase; TDT; terminal Deoxyribonucleotidyltransferase; terminal Deoxynucleotidyltransferase; Deoxynucleotidyltransferase, terminal; terminal Addi
Species:
Others
Source:
E. coli
Cat. No.: HY-185452
CAS No.: 28070-54-4
Target:
Research Areas:
N4-Acetyldeoxycytidine triphosphate is a terminal deoxynucleotidyl transferase substrate. N4-Acetyldeoxycytidine triphosphate acts as a substrate for calf thymus terminal deoxynucleotidyl transferase and undergoes polymerization to form extended polydeoxynucleotide chains .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
