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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
transferrin endocytosis
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "transferrin endocytosis" in MCE Product Catalog:
18
Target:
Research Areas:
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
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1 Cited Publications
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .
Cat. No.: HY-168943
Cat. No.: HY-186018
Pitstop 2d is a clathrin (Clathrin) terminal domain (TD) inhibitor with an IC50 of 1.7 μM. Pitstop 2d occupies the Clathrin box binding site within the clathrin TD, blocking the binding of endocytic protein ligands such as Epsin to clathrin. Pitstop 2d inhibits clathrin-mediated endocytosis (Endocytosis) and the cellular entry of vesicular stomatitis virus (VSV). Pitstop 2d has low cytotoxicity, does not disrupt the nuclear permeability barrier, and does not inhibit clathrin-independent endocytosis. Pitstop 2d can be used in studies related to endocytosis and vesicular stomatitis virus infection .
Cat. No.: HY-122564
CAS No.: 1440126-94-2
Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell [1.
Cat. No.: HY-168943A
Cat. No.: HY-168943B
Cat. No.: HY-168943C
Cat. No.: HY-D3122
Target:
Research Areas:
Mem-RhoNox is a fluorescent probe used to detect labile Fe (II) on the plasma membrane surface and inside endosomes during iron uptake in live cells. Mem-RhoNox can anchor to the extracellular surface of the plasma membrane; upon contact with Fe (II), its N-oxide group undergoes a deoxygenation reaction, converting weakly fluorescent Mem-RhoNox into strongly fluorescent Mem-Rhodamine. During transferrin-mediated endocytosis, Mem-RhoNox enters endosomes together with the transferrin-transferrin receptor complex, and reacts with Fe (II) released by transferrin to enable detection of endosomal Fe (II) .
Cat. No.: HY-13863R
CAS No.: 1256493-34-1
Target:
Research Areas:
Hydroxy-Dynasore (Standard) is the analytical standard of Hydroxy-Dynasore (HY-13863). This product is intended for research and analytical applications. Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
Cat. No.: HY-125188
CAS No.: 2306305-57-5
Target:
Research Areas:
NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
