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Results for "

translation initiation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Eukaryotic Initiation Factor (eIF) (20) AAK1 (1) ADC Payload (2) Akt (1) Amino Acid Derivatives (2) Antibiotic (9) AP-1 (1) Apoptosis (6) Autophagy (1) Bacterial (10) Bcl-2 Family (1) Biochemical Assay Reagents (2) c-Myc (4) Caspase (2) CDK (4) Cyclin G-associated Kinase (GAK) (1) DNA/RNA Synthesis (5) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (1) Environmental Pollutants (1) Fungal (1) HCV (2) HPV (2) HSP (2) HSV (2) Interleukin Related (1) LIM Kinase (LIMK) (1) MDM-2/p53 (3) Microtubule/Tubulin (1) MNK (1) mRNA (1) mTOR (1) NF-κB (4) P2Y Receptor (3) Phosphatase (1) PROTACs (1) Reference Standards (5) Salt-inducible Kinase (SIK) (1) SARS-CoV (1) Sirtuin (1) SnRK (1) Wee1 (1)
By Research Areas:	Cancer (26) Infection (20) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	mRNA (1) Antisense Oligonucleotides (6) Cap Analogs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Eukaryotic Initiation Factor (eIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108666

ATPγS tetralithium salt 1 Publications Verification Adenosine-5'-O-3-thiotriphosphate tetralithium salt; Adenosine 5'-[γ-thio]triphosphate tetralithium salt	Eukaryotic Initiation Factor (eIF) P2Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis .

HY-19356

Rocaglamide 25+ Cited Publications Roc-A	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-13251

Silvestrol Maximum Cited Publications 52 Publications Verification (-)-Silvestrol	Eukaryotic Initiation Factor (eIF) Apoptosis Autophagy	Cancer
Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis .

HY-13250

Silvestrol aglycone	Drug Derivative	Cancer
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC₅₀s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity .

HY-15969

Sal003 4 Publications Verification	Phosphatase Apoptosis	Cancer
Sal003 is a potent, specific and cell-permeable inhibitor of the *eukaryotic translation* initiation factor 2α (eIF2α) phosphatase**. Sal003 is a derivative of salubrinal .

HY-B1864A

Kasugamycin hydrochloride 1 Publications Verification Ksg hydrochloride	Environmental Pollutants Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-16366

Briciclib ON 014185	Eukaryotic Initiation Factor (eIF) CDK c-Myc MDM-2/p53 Caspase Apoptosis	Cancer
Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors .

HY-B1864B

Kasugamycin hydrochloride hydrate 1 Publications Verification Ksg hydrochloride hydrate	Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-148448

eIF4A3-IN-14	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the eIF4F translation complex, with EC₅₀ values of 40 nM and > 2000 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .

HY-10393

Eperezolid PNU-100592	Bacterial Antibiotic	Infection
Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of chloramphenicol (HY-B0239) and lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC₉₀ for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .

HY-148447

eIF4A-IN-3	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A-IN-3, Silvestrol (HY-13251) analogue, is an eIF4A inhibitor. eIF4A-IN-3 blocks protein translation initiation by interfering with eIF4F complex assembly, preferentially inhibiting translation of mRNAs with long, highly structured 5'-untranslated regions. eIF4A-IN-3 inhibits proliferation of human breast cancer cells. eIF4A-IN-3 has moderate apical to basolateral permeability in intestinal cell monolayers and a low efflux ratio .

HY-153108

3'-O-Me-m7G(5')ppp(5')A solution (100 mM) ARCA cap solution (100 mM)	DNA/RNA Synthesis	Others
3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation .

HY-19831A

(Z)-4EGI-1	Eukaryotic Initiation Factor (eIF)	Cancer
(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of **translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC₅₀ of 43.5 μM and a K_d** value of 8.74 μM. (Z)-4EGI-1 has anticancer activity .

HY-176844

eIF4A-IN-1 intermediate	ADC Payload Drug Intermediate	Cancer
eIF4A-IN-1 intermediate (Compound 71E) is an intermediate of *Eukaryotic translation* initiation factor 4A (eIF4A)** inhibitor. eIF4A-IN-1 intermediate can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-139098

7-Methyl-diguanosine triphosphate m7Gp3G	DNA/RNA Synthesis	Others
7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK	Others
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].

HY-N11857

Gentamicin C2	Antibiotic Bacterial	Infection
Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections .

HY-B1864

Kasugamycin 1 Publications Verification Ksg	Antibiotic Bacterial	Infection
Kasugamycin (Ksg) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-W348485

WRX606	mTOR	Cancer
WRX606 is an orally active nonrapalog inhibitor for mTOR complex 1 (mTORC1M). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (S6K1) (IC₅₀ = 10 nM) and eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC₅₀ = 0.27 μM) in MCF-7 cells. WRX606 suppresses tumor growth in mice without promotion of metastasis. WRX606 can be studied in research as an antitumor agent .

HY-148443

eIF4A3-IN-9	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the eIF4F translation complex, with EC₅₀ values of 29 and 450 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .

HY-134361

ATP-γ-S tetrasodium	P2Y Receptor Eukaryotic Initiation Factor (eIF)	Neurological Disease Metabolic Disease Inflammation/Immunology
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis .

HY-111522

RK-9123016	Sirtuin c-Myc	Cancer
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC₅₀ value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression .

HY-176843

eIF4A-IN-2	Eukaryotic Initiation Factor (eIF) ADC Payload	Cancer
eIF4A-IN-2 (Compound 93) is an *Eukaryotic translation* initiation factor 4A (eIF4A)** inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-148664

eIF4E-IN-4	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4E-IN-4 (Compound 33) is a selective inhibitor of *eukaryotic initiation* factor 4E (eIF4E)** with biochemical activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC₅₀ value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .

HY-129767

CMLD012612	Eukaryotic Initiation Factor (eIF)	Cancer
CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent *eukaryotic initiation* factor 4A (eIF4A)** inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC₅₀ value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity .

HY-177610

Afovirsen ISIS 2105	HPV	Infection
Afovirsen is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

HY-P11006

Onc112	Bacterial	Infection
Onc112 is a proline-rich antimicrobial peptide that displays potent activity against Gram-negative bacteria. Onc112 inhibits translation by blocking and destabilizing the initiation complex .

HY-177638

ISIS 1082	HSV	Infection
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-179110

ISR activator 1	Eukaryotic Initiation Factor (eIF)	Infection Cancer
ISR activator 1 (compound B) is an eIF2B allosteric inhibitor. ISR activator 1 stabilizes the inactive state of eIF2B, inhibits translation initiation and global protein synthesis, and selectively activates the ISR pathway. ISR activator 1 can be used for research on cancer and viral infections .

HY-19356B

(+)-Rocaglamide	Drug Derivative NF-κB HSP Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
(+)-Rocaglamide is the dextrorotatory enantiomer of Rocaglamide (HY-19356). Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of 50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

HY-106801

Girolline RP 49532	Interleukin Related NF-κB AP-1 MDM-2/p53 Apoptosis	Infection Inflammation/Immunology Cancer
Girolline (RP 49532) is a protein synthesis inhibitor and a functional modulator of eIF5A. Girolline induces ribosome stalling by interfering with the binding of eIF5A to ribosomes. Girolline also inhibits the production of IL-6 and IL-8, and induces cell cycle arrest in tumor cells. Girolline is applicable to research related to inflammatory diseases, solid tumors, leukemia and malaria .

HY-164524

SBI-0640726	Eukaryotic Initiation Factor (eIF) Akt NF-κB	Cancer
SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro .

HY-121722

Deoxyhypusine	Amino Acid Derivatives	Cancer
Deoxyhypusine is an unusual amino acid formed during the posttranslational modification of eukaryotic translation initiation factor 5A (eIF-5A) by the enzyme deoxyhypusine hydroxylase (DOHH) .

HY-177610A

Afovirsen sodium ISIS 2105 sodium	HPV	Infection
Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

HY-129769

CMLD012073	Eukaryotic Initiation Factor (eIF)	Cancer
CMLD012073 is an amidino-rocaglates and is a potent *eukaryotic initiation* factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC₅₀** of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) .

HY-155676

eIF4E-IN-5	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .

HY-153837A

ISIS 14803 sodium	HCV	Infection
ISIS 14803 sodium is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-153837

ISIS 14803	HCV	Infection
ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-177638A

ISIS 1082 sodium	HSV	Infection
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-N7151R

Aurachin D (Standard)	Reference Standards Antibiotic Bacterial Fungal	Infection
Kasugamycin (hydrochloride) (Standard) is the analytical standard of Kasugamycin (hydrochloride). This product is intended for research and analytical applications. Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-W235043

Methyl 3-oxodecanoate	DNA/RNA Synthesis	Infection
Methyl 3-Oxodecanoate has been shown to have virulence factor activity against human pathogens and is active against fluorescent haplophyllum and culture supernatant. Methyl 3-oxodecanoate has also been shown to inhibit DNA synthesis by inhibiting protein synthesis at the level of translation initiation. Reagent grade, for research purpose.

HY-B1864C

Kasugamycin sulfate Ksg sulfate	Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-122039

Hypusine dihydrochloride	Amino Acid Derivatives	Others
Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A). Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety .

HY-168326

Antiproliferative agent-64	DNA/RNA Synthesis Microtubule/Tubulin	Cancer
Antiproliferative agent-64 (Compound 76) is an inhibitor for *eukaryotic translation* initiation factor 4E (eIF4E*), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC₅₀* of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC₅₀ of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC₅₀ of 7 nM .

HY-174720

Human EIF2AK2 mRNA	mRNA	Inflammation/Immunology
Human EIF2AK2 mRNA encodes the human eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) protein, a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. EIF2AK2 plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation.

HY-B1864AR

Kasugamycin hydrochloride (Standard) Ksg hydrochloride (Standard)	Reference Standards Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride (Standard) is the analytical standard of Kasugamycin hydrochloride (HY-B1864A). This product is intended for research and analytical applications. Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-B1864BR

Kasugamycin hydrochloride hydrate (Standard) Ksg hydrochloride hydrate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate (Standard) is the analytical standard of Kasugamycin hydrochloride hydrate (HY-B1864B). This product is intended for research and analytical applications. Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-12770R

Mebeverine alcohol (Standard) Mebeverine metabolite Mebeverine alcohol (Standard)	Reference Standards Drug Metabolite	Neurological Disease
Mebeverine alcohol (Standard) is an analytical standard for Mebeverine alcohol. This product is intended for research and analytical applications. Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of Chloramphenicol (HY-B0239) and Lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .

HY-16366A

Briciclib sodium ON 014185 sodium	Eukaryotic Initiation Factor (eIF) CDK c-Myc MDM-2/p53 Caspase Apoptosis	Cancer
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors .

HY-183328

MNK1/2-IN-11	MNK Bcl-2 Family	Cancer
MNK1/2-IN-11 is a potent, selective and orally active MNK1/2 inhibitor with MNK1 IC₅₀ of 1.2 nM, MNK2 IC₅₀ of 1.3 nM. MNK1/2-IN-11 reduces eukaryotic translation initiation factor 4E phosphorylation, decreases Mcl-1 and Cyclin D1 expression. MNK1/2-IN-11 inhibits tumor growth in mouse CT26 colorectal tumor models. MNK1/2-IN-11 can be used for the research of colorectal cancer .

Cat. No.	Product Name	Type

HY-153108

3'-O-Me-m7G(5')ppp(5')A solution (100 mM)

ARCA cap solution (100 mM)

Biochemical Assay Reagents

3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation .

HY-139098

7-Methyl-diguanosine triphosphate

m7Gp3G

Biochemical Assay Reagents

7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

HY-139098A

7-Methyl-diguanosine triphosphate ammonium

m7Gp3G ammonium

Biochemical Assay Reagents

7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

Cat. No.	Product Name	Target	Research Area

HY-P11006

Onc112	Bacterial	Infection
Onc112 is a proline-rich antimicrobial peptide that displays potent activity against Gram-negative bacteria. Onc112 inhibits translation by blocking and destabilizing the initiation complex .

Species:	Human (18)
Tag:	SUMO (3) His (12) Tag Free (1) Myc (1) GST (7) B2M (1)
Source:	Sf9 insect cells (3) E. coli (15)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700506

	EIF3G Protein, Human (His-SUMO) eukaryotic translation initiation factor 3 subunit G; EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 RNA-binding subunit; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa	Human	E. coli
	The EIF3G protein is an RNA-binding component of the eIF-3 complex that initiates protein synthesis by promoting the recruitment of factors to form the 43S PIC. EIF3G is critical in both mRNA recruitment and AUG recognition scanning. EIF3G Protein, Human (His-SUMO) is the recombinant human-derived EIF3G protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P70207

	EIF1B Protein, Human (His) rHuEukaryotic translation initiation factor 1b/EIF1B, His; Eukaryotic translation initiation Factor 1b; eIF1b; Protein translation Factor SUI1 Homolog GC20; EIF1B	Human	E. coli
	EIF1B Protein likely intricately participates in translation, playing a crucial role in facilitating accurate and efficient protein synthesis within cellular machinery. Its involvement suggests a key function in orchestrating various steps required for proper decoding of mRNA and subsequent assembly of polypeptide chains. EIF1B Protein, Human (His) is the recombinant human-derived EIF1B protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70355

	EIF1AX Protein, Human (His) rHuEukaryotic translation initiation factor 1A, X-chromosomal/EIF1AX, His; Eukaryotic translation initiation Factor 1A X-Chromosomal; eIF-1A X Isoform; Eukaryotic translation initiation Factor 4C; eIF-4C; EIF1AX; EIF1A; EIF4C	Human	E. coli
	The EIF1AX protein is an important member of the 43S preinitiation complex (43S PIC) and is responsible for coordinating mRNA cap-proximal binding, scanning the 5'-untranslated region, and pinpointing the start codon. EIF1AX Protein, Human (His) is the recombinant human-derived EIF1AX protein, expressed by E. coli , with N-6*His labeled tag.

HY-P75255

	EIF5 Protein, Human (His) Eukaryotic translation initiation factor 5; eIF-5	Human	E. coli
	The EIF5 protein is a key member of the 43S pre-initiation complex (43S PIC) and actively participates in mRNA cap-proximal binding, scanning 5'-untranslated regions and locating start codons. EIF5 Protein, Human (GST) is the recombinant human-derived EIF5 protein, expressed by E. coli , with N-GST labeled tag.

HY-P70910

	EIF5A2 Protein, Human (His) Eukaryotic translation initiation factor 5A-2; Eukaryotic initiation factor 5A isoform 2; EIF5A2	Human	E. coli
	EIF5A2 is a translation factor critical for promoting elongation and termination, helping stalled ribosomes encounter specific amino acid environments. EIF5A2 is located between the ribosome exit (E) and peptidyl (P) sites and rescues stalled ribosomes, especially those translating polyproline-containing peptides. EIF5A2 Protein, Human (His) is the recombinant human-derived EIF5A2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700526

	EIF4A2 Protein, Human (GST) eukaryotic translation initiation factor 4A2; EIF4F, eukaryotic translation initiation factor 4A, isoform 2; eukaryotic initiation factor 4A-II; BM 010; DDX2B; EIF4A; ATP-dependent RNA helicase eIF4A-2; eukaryotic translation initiation factor 4A, isoform 2; EIF4F; BM-010; eIF4A-II; eIF-4A-II	Human	E. coli
	EIF4A2, an ATP-dependent RNA helicase, is a vital subunit of the eIF4F complex, pivotal in cap recognition and mRNA binding to ribosomes. In translation initiation, EIF4A2 crucially unwinds RNA secondary structures in mRNA 5'-UTRs. This activity facilitates small ribosomal subunit binding and efficient scanning for the initiator codon, orchestrating translation initiation. EIF4A2 Protein, Human (GST) is the recombinant human-derived EIF4A2 protein, expressed by E. coli , with N-GST labeled tag.

HY-P701439

	EIF3S5 Protein, Human (GST) EIF3F; Eukaryotic translation initiation factor 3 subunit F; eIF3f; Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47	Human	E. coli
	The EIF3S5 protein is an important component of the eukaryotic translation initiation factor 3 (eIF-3) complex and plays a crucial role in various stages of protein synthesis initiation. It stimulates mRNA recruitment, scans for AUG recognition, and promotes disassembly and recycling of posttermination ribosomal complexes within the 43S preinitiation complex (43S PIC). EIF3S5 Protein, Human (GST) is the recombinant human-derived EIF3S5 protein, expressed by E. coli , with N-GST labeled tag.

HY-P70152

	EIF4E Protein, Human rHuEukaryotic translation initiation factor 4E/EIF4E; Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; EIF4E; EIF4EL1; EIF4F	Human	E. coli
	IF4E protein plays multiple roles in cells, regulating processes such as protein synthesis, mRNA export, RNA processing and splicing. As part of the eIF4F protein complex, IF4E recognizes the mRNA cap and promotes ribosome binding. It is also involved in translation repression and regulation of mRNA stability. In P bodies, IF4E is involved in storing translationally inactive mRNA. In addition, IF4E also plays a role in spermatogenesis, neurogenesis, and mRNA nuclear-cytoplasmic transport. The ability of IF4E to participate in mRNA export relies on binding to the m7G cap and the EIF4E-sensitive element (4ESE). LRPPRC promotes the formation of EIF4E-dependent mRNA export complexes. The action of IF4E changes the composition of nuclear pores and promotes the nuclear export of specific mRNAs. EIF4E Protein, Human is the recombinant human-derived EIF4E protein, expressed by E. coli , with tag free.

HY-P70416

	EIF4EBP2 Protein, Human (His) rHuEukaryotic translation initiation factor 4E-binding protein 2/EIF4EBP2, His; Eukaryotic translation initiation Factor 4E-Binding Protein 2; 4E-BP2; eIF4E-Binding Protein 2; EIF4EBP2	Human	E. coli
	EIF4EBP2 is a translation initiation repressor protein that plays a critical regulatory role in synaptic plasticity, learning, and memory. In the hypophosphorylated state, EIF4EBP2 competes with EIF4G1/EIF4G3, forms a complex with EIF4E, and inhibits translation. EIF4EBP2 Protein, Human (His) is the recombinant human-derived EIF4EBP2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P78232

	EIF5A Protein, Human (His) Eukaryotic translation initiation factor 5A-1; eIF-5A1; Rev-binding factor; eIF-4D	Human	E. coli
	The GSK-3 beta protein is an enzyme that plays a crucial role in multiple cellular processes, including cell proliferation, differentiation, and apoptosis. It regulates various signaling pathways and is involved in the development of several diseases, such as cancer and neurodegenerative disorders. GSK-3 beta is active in its unphosphorylated form and can phosphorylate a wide range of substrates to modulate cellular functions. EIF5A Protein, Human (His) is the recombinant human-derived EIF5A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700519

	EIF1 Protein, Human (GST) eukaryotic translation initiation factor 1; A121; EIF 1; EIF1A; ISO1; SUI1; EIF-1	Human	E. coli
	The EIF1 protein is a key member of the 43S preinitiation complex (43S PIC), binding to the mRNA cap-proximal region, scanning the 5′-untranslated region, and localizing the initiation codon. EIF1 Protein, Human (GST) is the recombinant human-derived EIF1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P70415

	EIF4EBP1 Protein, Human (His) rHuEukaryotic translation initiation factor 4E-binding protein 1/EIF4EBP1, His; Eukaryotic translation initiation Factor 4E-Binding Protein 1; 4E-BP1; eIF4E-Binding Protein 1; Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1; PHAS-I; EIF4EBP1	Human	E. coli
	EIF4EBP1 is a translation initiation repressor protein that complexly regulates EIF4E activity. In the hypophosphorylated state, EIF4EBP1 competes with EIF4G1/EIF4G3 to inhibit translation by binding to EIF4E. EIF4EBP1 Protein, Human (His) is the recombinant human-derived EIF4EBP1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76901

	EIF3K Protein, Human (sf9, His-GST) Eukaryotic translation initiation factor 3 subunit K; PLAC-24; eIF-3 p25; EIF3S12	Human	Sf9 insect cells
	The eIF3K protein is an important component of the eukaryotic translation initiation factor 3 (eIF-3) complex and plays a crucial role in various steps of protein synthesis initiation.It stimulates recruitment of mRNA to the 43S preinitiation complex (43S PIC) and promotes AUG recognition scanning.EIF3K Protein, Human (sf9, His-GST) is the recombinant human-derived EIF3K protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P700566

	EIF5 Protein, Human (His-SUMO) 2810011H21Rik; D12Ertd549e; EIF 5; EIF 5A; eIF-5; Eif5; Eukaryotic initiation factor 5; Eukaryotic translation initiation factor 5; IF5_HUMAN; MGC36374; MGC36509	Human	E. coli
	The EIF5 protein is a key member of the 43S pre-initiation complex (43S PIC) and actively participates in mRNA cap-proximal binding, scanning 5'-untranslated regions and locating start codons. EIF5 Protein, Human (His-SUMO) is the recombinant human-derived EIF5 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P705590

	EIF2AK4 Protein, Human (sf9, His-GST) eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2; KIAA1338; EC:2.7.11.1	Human	Sf9 insect cells

HY-P705694

	EIF4G1 Protein, Human (His-B2M-JD, Myc) eIF 4 gamma 1; eIF 4G 1; eIF 4G1; eIF-4-gamma 1; EIF4G; Eukaryotic translation initiation factor 4 gamma 1	Human	E. coli
	EIF4G1 is a key component of the eIF4F complex and plays a critical regulatory role in translation initiation. EIF4G1 plays different roles in complexes with EIF1 or EIF4E. EIF4G1 Protein, Human (His-B2M-JD, Myc) is the recombinant human-derived EIF4G1 protein, expressed by E.coli , with N-10*-B2M-JD and C- Myc labeled tag.

HY-P71577

	EIF3M Protein, Human (His-SUMO) B5; B5 receptor; Dendritic cell protein; eIF3m; EIF3M_HUMAN; Eukaryotic translation initiation factor 3 subunit M; Fetal lung protein B5; FLJ29030; GA17; hfl B5; hFL-B5; PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; PCID1; TANGO7	Human	E. coli
	The EIF3M protein is a component of the eIF-3 complex and promotes protein synthesis initiation (eg, mRNA recruitment, scanning, and ribosomal subunit attachment) (PubMed:17403899, PubMed:25849773). EIF3M Protein, Human (His-SUMO) is the recombinant human-derived EIF3M protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P704016

	EIF2AK2 Protein, Human (Active, sf9, GST) eukaryotic translation initiation factor 2-alpha kinase 2; PRKR, protein kinase, interferon inducible double stranded RNA dependent; interferon-induced, double-stranded RNA-activated protein kinase; EIF2AK1; PKR; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein kinase, interferon-inducible double stranded RNA dependent; PRKR; MGC126524;	Human	Sf9 insect cells
	The EIF2AK2 protein is an interferon-inducing kinase that initiates the innate immune response against viral infection. It phosphorylates eIF-2-α, activating the integrated stress response, inhibiting overall protein synthesis and favoring ISR-specific mRNAs such as ATF4. EIF2AK2 Protein, Human (Active, sf9, GST) is the recombinant human-derived EIF2AK2 protein, expressed by Sf9 insect cells, with N-GST labeled tag.

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Molecular Weight
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Appearance
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (6) Rabbit (24)
Reactivity:	Transfected (2) Human (27) Rat (24) Mouse (23) Monkey (3) Hamster (2)
Application:	IHC-P (19) ICC/IF (15) IP (14) IHC-F (3) WB (30) ChIP (1) FC (5) ELISA (9)
Isotype:	IgG (23) IgG1 (3) IgG/Kappa (1)
Conjugation:	Non-conjugated (30)
Clonality:	Polyclonal (1) Monoclonal (24) Recombinant (13)
Modification:	Phosphorylated (7) Unmodified (18)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86151

	eIF4B Antibody (YA5843) Eukaryotic translation initiation factor 4B; eIF-4B;	WB, IHC-P, ICC/IF, IP, ELISA	Human
	eIF4B Antibody (YA5843) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4B.

HY-P86419

	EIF2S1 Antibody (YA6111) EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EIF2S1 Antibody (YA6111) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EIF2S1.

HY-P80811

	Phospho-EIF2S1 (Ser51) Antibody (YA203) 3 Publications Verification EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB	Human, Mouse, Rat
	Phospho-EIF2S1 (Ser51) Antibody (YA203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EIF2S1 (Ser51).

HY-P86860

	EIF3S1/EIF3J Antibody (YA6553) eIF 3 alpha antibody; eIF-3-alpha antibody; eIF3 alpha antibody; eIF3 p35 antibody; eIF3j antibody; EIF3J_HUMAN antibody; EIF3S 1 antibody; EIF3S1 antibody; Eukaryotic translation initiation factor 3 subunit 1 antibody; Eukaryotic translation initiation factor 3 subunit J antibody; eIF 3 alpha antibody; eIF-3-alpha antibody; eIF3 alpha antibody; eIF3 p35 antibody; eIF3j antibody; EIF3J_HUMAN antibody; EIF3S 1 antibody; EIF3S1 antibody; Eukaryotic translation initiation factor 3 subunit 1 antibody; Eukaryotic translation initiation factor 3 subunit J antibody; Eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD) antibody; Eukaryotic translation initiation factor 3, subunit 1 alpha, 35kD antibody;	WB, ICC/IF, IHC-P, FC	Human, Rat, Monkey
	EIF3S1/EIF3J Antibody (YA6553) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EIF3S1/EIF3J.

HY-P80811A

	Phospho-EIF2S1 (Ser51) Antibody (YA203)(PBS only) EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB	Human, Mouse, Rat
	Phospho-EIF2S1 (Ser51) Antibody (YA203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EIF2S1 (Ser51).

HY-P86859

	EIF3H Antibody (YA6552) eIF-3-gamma antibody; eIF3 gamma antibody; eIF3 p40 antibody; eIF3 p40 subunit antibody; eIF3h antibody; EIF3H_HUMAN antibody; EIF3S3 antibody; Eukaryotic translation initiation factor 3 subunit 3 antibody; Eukaryotic translation initiation factor 3 subunit H antibody; MGC102958 antibody;	WB, IHC-P	Human, Mouse, Rat
	EIF3H Antibody (YA6552) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EIF3H.

HY-P80781

	PERK Antibody (YA233) EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB	Human, Mouse, Rat
	PERK Antibody (YA233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

HY-P85324

	PERK Antibody (YA5016) EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB, ELISA	Mouse, Rat
	PERK Antibody (YA5016) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PERK.

HY-P86542

	PERK Antibody (YA6234) EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PERK Antibody (YA6234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

HY-P85622

	eIF4EBP2 Antibody (YA5314) 4E-BP2; 4EBP2; 4EBP2_HUMAN; eIF4E binding protein 2; eIF4E-binding protein 2; Eif4ebp2; Eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II.	WB	Transfected
	eIF4EBP2 Antibody (YA5314) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP2.

HY-P85623

	eIF4EBP3 Antibody (YA5315) 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879.	WB	Transfected
	eIF4EBP3 Antibody (YA5315) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP3.

HY-P87156

	eIF3A Antibody (YA6849) centrosomin homolog antibody; cytoplasmic protein p167 antibody; eIF 3 theta antibody; eIF-3-theta antibody; EIF3 antibody; eIF3 p167 antibody; eIF3 p170 antibody; eIF3 p180 antibody; EIF3 p180 subunit antibody; eIF3 p185 antibody; centrosomin homolog antibody; cytoplasmic protein p167 antibody; eIF 3 theta antibody; eIF-3-theta antibody; EIF3 antibody; eIF3 p167 antibody; eIF3 p170 antibody; eIF3 p180 antibody; EIF3 p180 subunit antibody; eIF3 p185 antibody; eIF3 theta antibody; eIF3a antibody; EIF3A_HUMAN antibody; EIF3S10 antibody; eukaryotic translation initiation factor 3 subunit 10 (theta 150 170kD) antibody; eukaryotic translation initiation factor 3 subunit 10 (theta 170kD) antibody; eukaryotic translation initiation factor 3 subunit 10 170kDa antibody; Eukaryotic translation initiation factor 3 subunit 10 antibody; eukaryotic translation initiation factor 3 subunit 10 theta 150 170kDa antibody; Eukaryotic translation initiation factor 3 subunit A antibody; OTTHUMP00000020589 antibody; P167 antibody; p180 antibody; p185 antibody; TIF32 antibody;	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	eIF3A Antibody (YA6849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF3A.

HY-P87155

	eIF-6 Antibody (YA6848) b(2)gcn antibody; B(2)GCN homolog antibody; B4 integrin interactor antibody; Binding protein of beta-4 integrin antibody; CAB antibody; eIF-6 antibody; EIF3A antibody; EIF6 antibody; Eukaryotic translation initiation factor 3A antibody; Eukaryotic translation initiation factor 6 antibody; b(2)gcn antibody; B(2)GCN homolog antibody; B4 integrin interactor antibody; Binding protein of beta-4 integrin antibody; CAB antibody; eIF-6 antibody; EIF3A antibody; EIF6 antibody; Eukaryotic translation initiation factor 3A antibody; Eukaryotic translation initiation factor 6 antibody; IF6_HUMAN antibody; Integrin beta 4 binding protein antibody; ITGB4BP antibody; OK/SW-cl.27 antibody; p27 beta 4 integrin binding protein antibody; p27(BBP) antibody; p27BBP antibody; RP4-614O4.1 antibody;	WB	Human, Mouse, Rat
	eIF-6 Antibody (YA6848) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to eIF-6.

HY-P80781A

	PERK Antibody (YA233)(PBS only) EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB	Human, Mouse, Rat
	PERK Antibody (YA233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

HY-P85133

	eIF4E Antibody (YA4825) EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-P, ICC/IF, FC, ELISA	Human
	eIF4E Antibody (YA4825) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4E.

HY-P86175

	eIF4E Antibody (YA5867) EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	eIF4E Antibody (YA5867) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4E.

HY-P80812

	Phospho-eIF4E (Ser209) Antibody (YA202) EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-eIF4E (Ser209) Antibody (YA202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4E (Ser209).

HY-P80812A

	Phospho-eIF4E (Ser209) Antibody (YA202)(PBS only) EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-eIF4E (Ser209) Antibody (YA202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4E (Ser209).

HY-P80526

	eIF4EBP1 Antibody (YA650) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	eIF4EBP1 Antibody (YA650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P86157

	PKR Antibody (YA5849) EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PKR Antibody (YA5849) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PKR.

HY-P86332

	eIF4EBP1 Antibody (YA6024) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	eIF4EBP1 Antibody (YA6024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P80786

	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1 (Thr46).

HY-P80526A

	eIF4EBP1 Antibody (YA650)(PBS only) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	eIF4EBP1 Antibody (YA650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P81299A

	Phospho-PKR (Thr446) Antibody (YA1026) EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB, IHC-P, IP, ChIP	Human
	Phospho-PKR (Thr446) Antibody (YA1026) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKR (Thr446).

HY-P86088

	Phospho-eIF4EBP1(Thr37/46) Antibody (YA5780) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-eIF4EBP1(Thr37/46) Antibody (YA5780) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1(Thr37/46).

HY-P81299

	Phospho-PKR (Thr451) Antibody (YA1025) EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k	WB	Human
	Phospho-PKR (Thr451) Antibody (YA1025) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PKR (Thr451).

HY-P80786A

	Phospho-eIF4EBP1 (Thr46) Antibody (YA230)(PBS only) EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1 (Thr46).

HY-P87157

	eIF4A2 Antibody (YA6850) ATP dependent RNA helicase eIF4A 2 antibody; ATP-dependent RNA helicase eIF4A-2 antibody; BM-010 antibody; DDX2B antibody; eIF 4A II antibody; eIF-4A-II antibody; EIF4A antibody; eIF4A II antibody; eIF4A-II antibody; EIF4A2 antibody; ATP dependent RNA helicase eIF4A 2 antibody; ATP-dependent RNA helicase eIF4A-2 antibody; BM-010 antibody; DDX2B antibody; eIF 4A II antibody; eIF-4A-II antibody; EIF4A antibody; eIF4A II antibody; eIF4A-II antibody; EIF4A2 antibody; EIF4F antibody; Eukaryotic initiation factor 4A II antibody; Eukaryotic initiation factor 4A-II antibody; eukaryotic translation initiation factor 4A isoform 2 antibody; Eukaryotic translation initiation factor 4A2 antibody; IF4A2_HUMAN antibody; N-terminally processed antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat, Monkey
	eIF4A2 Antibody (YA6850) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4A2.

HY-P81190

	Phospho-PERK (Thr980) Antibody 2 Publications Verification p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); mo(Thr980)/hu (Thr982)/rat (Thr974); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	Phospho-PERK (Thr980) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-PERK (Thr980).

HY-P83763

	EIF2S1 Antibody(YA3562) EIF 2 alpha antibody; EIF 2 antibody; EIF 2A antibody; EIF 2alpha antibody; eIF-2-alpha antibody; eIF-2A antibody; EIF-2alpha antibody; EIF2 alpha antibody; EIF2 antibody; EIF2A antibody; EIF2S1 antibody; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa antibody; IF2A_HUMAN antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat, Monkey
	EIF2S1 Antibody(YA3562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EIF2S1.

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-153108

3'-O-Me-m7G(5')ppp(5')A solution (100 mM) ARCA cap solution (100 mM)		Cap Analogs
3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation .

HY-139098

7-Methyl-diguanosine triphosphate m7Gp3G		Cap Analogs
7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

HY-177610

Afovirsen ISIS 2105		Antisense Oligonucleotides
Afovirsen is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

HY-177638

ISIS 1082		Antisense Oligonucleotides
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-177610A

Afovirsen sodium ISIS 2105 sodium		Antisense Oligonucleotides
Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

HY-153837A

ISIS 14803 sodium		Antisense Oligonucleotides
ISIS 14803 sodium is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-153837

ISIS 14803		Antisense Oligonucleotides
ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-177638A

ISIS 1082 sodium		Antisense Oligonucleotides
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-174720

Human EIF2AK2 mRNA		mRNA
Human EIF2AK2 mRNA encodes the human eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) protein, a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. EIF2AK2 plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation.

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