6980-18-3
6980-18-3
Chemical Structure
Kasugamycin
Synonym(s): Ksg
- CAS No.: 6980-18-3
- Formula:C14H25N3O9
- Molecular Weight:379.36
IUPAC Name: 2-(((2R,3S,5S,6R)-5-amino-2-methyl-6-(((1S,2R,3S,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)amino)-2-iminoacetic acid
InChIKey: PVTHJAPFENJVNC-MHRBZPPQSA-N
SMILES: OC(C(N[C@@H](C[C@@H]1N)[C@@H](C)O[C@]1([H])O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]2O)=N)=O
Biological Activity: Kasugamycin (Ksg) is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin possesses anti-infective activity. Kasugamycin is used in research on bacterial translation and Pseudomonas infection[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kasugamycin | 99.84% | Kasugamycin (Ksg) is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin possesses anti-infective activity. Kasugamycin is used in research on bacterial translation and Pseudomonas infection. | ||||||||||||||||||||
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Galactinol dihydrate | 98.0% | Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot. | ||||||||||||||||||||
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Paromamine | Paromamine is an antibiotic that recognizes ribosomal RNA (rRNA) components. | |||||||||||||||||||||
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Kasugamycin hydrochloride (Standard) | ≥98% | Kasugamycin hydrochloride (Standard) (Ksg hydrochloride (Standard)) is the analytical standard of Kasugamycin hydrochloride (HY-B1864A). This product is intended for research and analytical applications. Kasugamycin (Ksg) hydrochloride is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin hydrochloride binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin hydrochloride possesses anti-infective activity. Kasugamycin hydrochloride is used in research on bacterial translation and Pseudomonas infection. | ||||||||||||||||||||
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Kasugamycin hydrochloride hydrate | 99.93% | Kasugamycin (Ksg) hydrochloride hydrate is an aminoglycoside antibiotic (antibiotic) that binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate binds to the P-site and E-site codon regions in the mRNA channel and interferes with mRNA-tRNA codon-anticodon interactions, thereby destabilizing initiator tRNA binding. Kasugamycin hydrochloride hydrate possesses anti-infective activity. Kasugamycin hydrochloride hydrate is used in research on bacterial translation and Pseudomonas infection. | ||||||||||||||||||||
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Galactinol | 99.92% | Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot. | ||||||||||||||||||||
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Blood group H disaccharide | Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes. | |||||||||||||||||||||
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2-Acetamido-2-deoxy-6-O-(α-L-fucopyranosyl)-D-glucopyranose | 2-Acetamido-2-deoxy-6-O-(α-L-fucopyranosyl)-D-glucopyranose is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology. | |||||||||||||||||||||
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Fuc1-α-3GlcNAc1-β-Ome | Fuc1-α-3GlcNAc1-β-Ome is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology. | |||||||||||||||||||||
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Isogalactinol | Isogalactinol is a biochemical assay reagent. | |||||||||||||||||||||
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Amikacin impurity 2 | Amikacin impurity 2 (compound Impurity VI) is an impurity of Amikacin (HY-B0509A) identified in Amikacin sulfate (HY-107813). | |||||||||||||||||||||
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References
- [1]. Zhang H, et al. Simultaneous determination of kasugamycin and validamycin-A residues in cereals by consecutive solid-phase extraction combined with liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2018 Mar;35(3):487-497. [Content Brief]
- [2]. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nature structural & molecular biology. 2006 Oct;13(10):871-8. [Content Brief]
- [3]. Kasuga K, et al. Heterologous production of kasugamycin, an aminoglycoside antibiotic from Streptomyces kasugaensis, in Streptomyces lividans and Rhodococcus erythropolis L-88 by constitutive expression of the biosynthetic gene cluster. Applied microbiology and biotechnology. 2017 May;101(10):4259-4268. [Content Brief]
- [4]. Takeuchi T, et al. Pharmacology of kasugamycin and the efeect on Pseudomonas infection. J Antibiot. 1965;18:107-110.
