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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
tri-GalNAc
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "tri-GalNAc" in MCE Product Catalog:
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Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .
Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .
Tri-GalNAc(OAc)3 is a trivalent N-acetylgalactosamine (tri-GalNAc) derivative, which can be used as a linker to synthesize LYTACs .
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tri-GalNAc biotin is a biotinylated ASGPR (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC) .
tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .
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TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies .
Cat. No.: HY-157950
CAS No.: 2936651-86-2
DSPE-PEG2K-triGalNAc ammonium is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).
Cat. No.: HY-145368B
Purity: ≥95.0%
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Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation.Tri-GalNAc(OAc)3-Perfluorophenyl can be used for the study of liver metabolism .
Cat. No.: HY-171910
CAS No.: 3099288-71-5
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tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .
Cat. No.: HY-145013
CAS No.: 3008204-26-7
tri-GalNAc-COOH acetylation is the acetylated and modified form of tri-GalNAc-COOH. tri-GalNAc-COOH acetylation can be used for the synthesis of LYTAC.
Cat. No.: HY-171987
CAS No.: 1469730-77-5
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trans-4-Hydroxyprolinol-C10-tri-GalNAc (Formula XXIV) is a Tri-GaINAc derivative that can be used for nucleic acid drug coupling .
Cat. No.: HY-P5045
CAS No.: 133575-43-6
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Cat. No.: HY-171342
CAS No.: 2893765-20-1
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Mal-C2-amide-C10-tri-GalNAc is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases .
Cat. No.: HY-185590
CAS No.: 3084453-02-8
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tri-GalNAc-phosphoric acid is a specific ligand of ASGPR with cell-specific internalization capability. tri-GalNAc-phosphoric acid can mediate the delivery of conjugated sclerostin aptamers to lysosomes of cells expressing ASGPR. tri-GalNAc-phosphoric acid is applicable to anticancer research .
Cat. No.: HY-184774
CAS No.: 1551528-06-3
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tri-GalNAc-C10-COOH (P290 232) is a targeted delivery intermediate composed of a trivalent N-acetylgalactosamine (GalNAc) cluster attached to a C10 linker ending with a carboxylic acid (-COOH) group. tri-GalNAc-C10-COOH is a standard building block used to synthesize LYTACs (lysosome-targeting chimeras) and cell-specific oligonucleotides like siRNA or ASO therapeutics .
Cat. No.: HY-173261
CAS No.: 1159408-63-5
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Tri-GalNAc(OAc)3-Cbz is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Cat. No.: HY-P5511
CAS No.: 869012-68-0
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Cat. No.: HY-P5508
CAS No.: 869012-67-9
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Cat. No.: HY-P5512
CAS No.: 869012-66-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
