DSPE-PEG2000-triGalNAc ammonium 

DSPE-PEG2K-triGalNAc ammonium is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

DSPE, or distearate phosphatidylethanolamine, is a phospholipid molecule with excellent biocompatibility and membrane fusion capabilities.
PEG, or polyethylene glycol, is a commonly used polymer that can increase the stability and bioavailability of materials.
A multivalent structure composed of three GalNAc units, it achieves highly selective enrichment of liver cells by recognizing the desialylate glycoprotein receptor (ASGPR) on the surface of hepatocytes with high affinity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2000(Average)

(C₂H₄O)_nC₉₇H₁₈₀N₉O₃₈P_.H₃N

2936651-86-2

Solid

White to off-white

CCCCCCCCCCCCCCCCCC(O[C@]([H])(COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCNC(COCCOCC(NCCCCC(N(CC(NCCOCCOCCO[C@H]1O[C@H]([C@H]([C@H]([C@@H]1NC(C)=O)O)O)CO)=O)CC(NCCOCCOCCO[C@H]2O[C@H]([C@H]([C@H]([C@@H]2NC(C)=O)O)O)CO)=O)C(NCCOCCOCCO[C@H]3O[C@H]([C@H]([C@H]([C@@H]3NC(C)=O)O)O)CO)=O)=O)=O)([O-])=O)=O.[NH4+].[n]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Green Ahn, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021, 17, 9.