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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
troponin I
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "troponin I" in MCE Product Catalog:
Target:
Research Areas:
GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure .
Cat. No.: HY-W996116
CAS No.: 1933460-23-1
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
AZM198 is an orally active myeloperoxidase (MPO) inhibitor. AZM198 irreversibly inactivates MPO (IC50=0.015 μM) via covalent binding to the heme prosthetic group, preferentially targets extracellular MPO activity, and reduces neutrophil extracellular trap formation, reactive oxygen species production and degranulation. AZM198 increases the fibrous cap thickness of atherosclerotic plaques, reduces lesion area, ameliorates hepatic steatosis and fibrosis in non-alcoholic steatohepatitis, and alleviates proteinuria and inflammatory infiltration associated with glomerulonephritis. AZM198 also decreases circulating levels of high-sensitivity Cardiac Troponin I and IL-1β, and mitigates endothelial cell injury. Therefore, AZM198 is suitable for research on various MPO-related diseases, including atherosclerotic cardiovascular disease, myocardial infarction, ischemic stroke, non-alcoholic steatohepatitis and crescentic glomerulonephritis .
Cat. No.: HY-P11206A
Synonyms: Murine cardiac TnI peptide TFA
Target:
Research Areas:
Murine cardiac troponin I peptide TFA (Murine cardiac TnI peptide TFA) is a murine cardiac troponin I (cTnI) peptide. Murine cardiac troponin I peptide TFA can induce significant myocardial inflammation followed by fibrosis and heart failure with increased mortality in mice model. Murine cardiac troponin I peptide TFA can be used for heart failure research .
Target:
Research Areas:
GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 μM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue .
Cat. No.: HY-P11206
Synonyms: Murine cardiac TnI peptide
Target:
Research Areas:
Murine cardiac troponin I peptide (Murine cardiac TnI peptide) is a murine cardiac troponin I (cTnI) peptide. Murine cardiac troponin I peptide can induce significant myocardial inflammation followed by fibrosis and heart failure with increased mortality in mice model. Murine cardiac troponin I peptide can be used for heart failure research .
Cat. No.: HY-137749A
Synonyms: 2'-Deoxy-3'-MANT-ADP trisodium
Target:
Research Areas:
MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y12 receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils .
Cat. No.: HY-130272
CAS No.: 2387506-35-4
Target:
Research Areas:
Anti-MI/R injury agent 1 (compound 18), a Panaxatriol derivative, is an orally active, potent anti-myocardial ischemia/reperfusion (anti-MI/R) injury agent. Anti-MI/R injury agent 1 enhances oxygen-glucose deprivation and reperfusion (OGD/R)-induced cardiomyocyte injury cell viability. Anti-MI/R injury agent 1 can markedly reduce myocardial infarction size, decrease circulating cardiac troponin I (cTnI) leakage, and alleviate cardiac tissue damage in the rats .
Cat. No.: HY-176316S
Cat. No.: HY-P2142
CAS No.: 98353-69-6
Research Areas:
Troponin I (104-115) is a polypeptide derived from Troponin I. Troponin I is an inhibitor of Acto-S1-TM ATPase, with an IC50 of 2.25 μM against skeletal muscle Acto-S1-TM ATP enzyme . Troponin I is used in research on muscle contraction-relaxation and restrictive cardiomyopathy .
Cat. No.: HY-P71469
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNNI3; troponin I Type 3 (Cardiac); Prev. CMD2A; troponin I Type 3; TNNC1; Mutant Cardiac troponin I; troponin I, Cardiac Muscle; troponin I Type 3 Cardiac; CMH7; CMD1FF; CTNI; RCM1; Cardiomyopathy, Dilated 2A (Autosomal Recessive); troponin I3, Cardiac T
Species:
Mouse
Source:
E. coli
Cat. No.: HY-N18070
CAS No.: 25090-71-5
Target:
Cat. No.: HY-P81144
Synonyms: troponin I type 3 (cardiac); Cardiac troponin I; troponin I, cardiac muscle; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; troponin I cardiac; troponin I cardiac muscle; troponin I cardiac muscle isoform; troponin I type 3 cardiac; troponin I, cardiac 3; troponinI; troponin I; TNNI3_HUMAN.
Cat. No.: HY-P705691
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: troponin I, cardiac muscle; Cardiac troponin I; TNNI3; TNNC1
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
