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Results for "

trypanosome alternative oxidase

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

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Natural
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178064
    Antiparasitic agent-29

    		Parasite Mitochondrial Metabolism Infection
    Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC50 of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .
    Antiparasitic agent-29
  • HY-176253
    Antitrypanosomal agent 26

    		Parasite Infection
    Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .
    Antitrypanosomal agent 26
  • HY-W414557
    Ethyl 2,4-dihydroxybenzoate

    		Drug Derivative Others
    Ethyl 2,4-dihydroxybenzoate is an ethyl ester derivative of 2,4-dihydroxybenzoate. The biological activities of Ethyl 2,4-dihydroxybenzoate are all mediated by its parent nucleus 2,4-dihydroxybenzoate .
    Ethyl 2,4-dihydroxybenzoate

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