MB-0223
MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM).
For research use only. We do not sell to patients.
- CAS No.: 2247732-89-2
- Formula: C26H27N5OS
- Molecular Weight:457.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13863
Hydroxy-DynasoreDynamin I/II Inhibitor -
HY-152086
DRP1i27Drp1 Inhibitor -
HY-145080
Dynole 2−24Dynamin GTPase Inhibitor -
HY-125222
Drp1-IN-1Drp1 Inhibitor -
HY-131873
Dynapyrazole-ADynamin Inhibitor -
HY-152215
Dynamin IN-1Dynamin Inhibitor -
HY-W013158
Trimethyloctadecylammonium bromideDynamin Inhibitor -
HY-123572
Bis-T-23HIV-I Integrase Inhibitor -
HY-152216
Dynamin IN-2Dynamin Inhibitor -
HY-118244
Clathrin-IN-3Clathrin Inhibitor
Biological Activity
Description
IC50 & Target
IC50: 1.3 μM (Drp1)[1]
In Vitro
MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1].MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 2247732-89-2
-
Molecular Weight 457.59
-
Formula C26H27N5OS
-
SMILES
O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MB-0223 Related Classifications
HY-131037 Related Classifications
Powered by Bioz