2. Stem Cell/Wnt
  3. Smo
  4. SMO-IN-4

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity.

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SMO-IN-4

SMO-IN-4 構造式

CAS 番号 : 1567963-99-8

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SMO-IN-4 関連抗体

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製品説明

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity[1].

体外実験

SMO-IN-4 (10 μM) shows minimal inhibition of all CYP isoforms, and also has low inhibition on hERG (IC50 = 38 µM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMO-IN-4 関連抗体
体内実験

SMO-IN-4 (50 mg/kg, daily by oral gavage) leads to regression of subcutaneous tumor in a subcutaneous xenograft model of Ptch1+/- mouse medulloblastoma[2].
PK properties of SMO-IN-4 (compound 24)[2].

Species Dose (mg/kg) AUC0-24h (ng·h/mL) Cmax (ng/mL) t1/2 (h) F%
Mouse p.o. (10 mg/kg) 4183 4132 1.0 49
Rat p.o. (10 mg/kg) 5541 2180 2.3 62
Dog p.o. (5 mg/kg) 7656 1300 5.4 72

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

450.96

分子式

C24H27ClN6O
CAS 番号
SMILES

ClC1=CN=C(N2CC3=CN=C(N4CCC(CC4)O)N=C3CC2)C=C1C5=C(C)C=C(C)C=N5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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SMO-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-41567963-99-8SmoSmoothenedtumorxenograft modelPtch1medulloblastomaInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-153499
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