Sodium caseinates

Cat. No.: HY-139410: Data Sheet
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Sodium caseinates is a kind of sodium salts of major milk proteins, which act as protein-based biopolymers and innate immune system activators. Sodium caseinates induce granulopoiesis, activation and differentiation, promote the production of M-CSF, and increase serum levels of G-CSF and GM-CSF. Sodium caseinates inhibit the proliferation and reduce the viability of leukemia macrophage-like cells, thereby significantly improving the survival rate of mice inoculated with leukemia cells. Sodium caseinates can serve as carriers for probiotics in edible films and exhibit anti-Listeria activity. Sodium caseinates effectively protect vitamin A from degradation, enhance its stability, bioaccessibility and bioavailability, and regulate protein digestibility when complexed with vitamin A. Sodium caseinates can be applied to research related to acute monocytic leukemia and vitamin A deficiency.

For research use only. We do not sell to patients.

Sodium caseinates Chemical Structure

CAS No. : 9005-46-3

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Purity & Documentation
References
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Description

In Vitro

Sodium caseinates induce differentiation of mouse bone marrow band granulocytes and increase their M-CSF production in vitro^[1].
Sodium caseinate (4% (w/v); 9 days at 4°C) films containing Lactobacillus acidophilus exhibit significant antilisterial activity against Listeria monocytogenes PTCC 1163 after 9 days at 4°C, while films containing Lactobacillus casei only show significant activity after 6 days at 4°C compared to control sodium caseinate films^[2].
Sodium caseinates (0.5-2.0 mg/mL; 72 h) inhibits proliferation and induces macrophagic differentiation of J774 leukaemia macrophage-like cells without reducing cell viability^[3].
Sodium caseinates (2.0 mg/mL; 24-120 h) inhibits proliferation of J774 leukaemia macrophage-like cells starting at 48 h and significantly reduces cell viability to ~15% after 120 h of incubation^[3].
Sodium caseinates (¹³ μM VA; 20 h) do not exhibit cytotoxicity toward Caco-2 cells, resulting in 80-90% cell viability after 20 h of incubation with ¹³ μM VA^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	J774 leukaemia macrophage-like cells
Concentration:	0.5 mg/mL; 1.0 mg/mL; 2.0 mg/mL
Incubation Time:	72 h
Result:	Reduced J774 cell proliferation index to ~50% at 1.0 mg/mL. Reduced J774 cell proliferation index to ~40% at 2.0 mg/mL. Did not reduce J774 cell viability at 0.5, 1.0, and 2.0 mg/mL. Induced macrophagic differentiation of J774 cells at 1.0 and 2.0 mg/mL.

In Vivo

Sodium caseinate (10% (w/v) in PBS, 1 mL per dose; i.p.; four times every 48 hours; 6 days) induces granulopoiesis with functional granulocytes in healthy BALB/c mice, increasing the percentage of BrdU+/Gr-1+ granulocytic lineage cells to 64.94%, serum G-CSF levels to 3189 pg/mL, and the granulocyte phagocytic index to 0.6^[1].
Sodium caseinate (1 mL of 10% (w/v); i.p.; every 48 hours) increases survival of J774-induced leukaemic BALB/c mice to 60% in females and 50% in males at 160 days, while reducing splenomegaly, hepatomegaly, and tumour burden^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c (male, 8-12 weeks old)^[1]
Dosage:	10% (w/v) in PBS, 1 mL per dose
Administration:	i.p.; four times every 48 hours; 6 days
Result:	Increased total bone marrow leukocyte count to 34.6 × 10⁶ cells per femur, and mononuclear cell count to 4.8 × 10⁶ cells per femur. Increased percentage of myeloblasts, band cells, and segmented granulocytes in bone marrow, with a corresponding decrease in lymphocyte population. Increased BrdU incorporation in bone marrow mononuclear cells to 34.86%, and increased percentage of BrdU+/Gr-1+ granulocytic lineage cells to 64.94%. Increased serum G-CSF levels to 3189 pg/mL, and increased bone marrow plasma G-CSF levels to 1160 pg/mL; serum GM-CSF levels were detectable at 1.25 pg/mL. Increased granulocyte phagocytic index to 0.6.

Animal Model:	BALB/c (8-12 weeks old; female and male; intraperitoneal inoculation with 1.0×10⁶ J774 leukaemia macrophage-like cells)^[3]
Dosage:	1 mL of 10% (w/v)
Administration:	i.p.; every 48 hours
Result:	Significantly reduced splenomegaly, hepatomegaly, and solid tumour burden in leukaemic mice. Extended survival of treated mice: 60% of female mice survived beyond 160 days, and 50% of male mice survived beyond 160 days (all untreated leukaemic mice died before 100 days). Eliminated residual autonomous leukaemic cell growth, as mononuclear bone marrow cells isolated from treated surviving mice did not proliferate in vitro without recombinant mouse interleukin-3.

CAS No.

9005-46-3

Appearance

Solid

Color

White to off-white

SMILES

[Sodium caseinates]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

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Data Sheet (273 KB) SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)

References

[1]. Domínguez-Melendez V, et al. Sodium caseinate induces mouse granulopoiesis. Inflamm Res. 2012;61(4):367-373. [Content Brief]

[2]. Abdollahzadeh E, et al. Effects of probiotic cells on the mechanical and antibacterial properties of sodium-caseinate films[J]. Applied Food Biotechnology, 2018, 5(3): 155-162.

[3]. Córdova-Galaviz Y, et al. Sodium caseinate induces increased survival in leukaemic mouse J774 model. In Vivo. 2014;28(5):819-825.

[4]. Rana S, et al. Effect of sodium caseinate and vitamin A complexation on bioaccessibility and bioavailability of vitamin A in Caco-2 cells. Food Res Int. 2019;121:910-918.