2. Anti-infection Cell Cycle/DNA Damage
  3. Dengue Virus Flavivirus Virus Protease DNA/RNA Synthesis
  4. SP-471P

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

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SP-471P

SP-471P Chemische Struktur

CAS. Nr. : 2768011-36-3

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SP-471P Related Antibodies

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Beschreibung

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis[1].

IC50 & Target

EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 100 μM
Compound: 32a; SP-471P
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
[PMID: 34298282]
PBMC CC50
> 100 μM
Compound: 32a; SP-471P
Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
[PMID: 34298282]
In Vitro

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471P Related Antibodies

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 6-54 hours
Result: Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 30 hours
Result: Targeted the NS3int cleavage site of DENV.
Molekulargewicht

604.50

Formel

C33H26BrN5O2
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Reinheit & Dokumentation
Verweise
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SP-471P Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-471P2768011-36-3Dengue VirusFlavivirusVirus ProteaseDNA/RNA SynthesisDENVDengue virusRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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