2. Anti-infection Cell Cycle/DNA Damage
  3. Dengue Virus Flavivirus Virus Protease DNA/RNA Synthesis
  4. SP-471P

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

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SP-471P

SP-471P 화학구조

CAS No. : 2768011-36-3

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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SP-471P Related Antibodies

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  • 순도&문서

  • References

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제품 설명

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis[1].

IC50 & Target

EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 100 μM
Compound: 32a; SP-471P
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
[PMID: 34298282]
PBMC CC50
> 100 μM
Compound: 32a; SP-471P
Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
[PMID: 34298282]
In Vitro

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471P Related Antibodies

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 6-54 hours
Result: Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 30 hours
Result: Targeted the NS3int cleavage site of DENV.
분자량

604.50

화학식

C33H26BrN5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
선적

Room temperature in continental US; may vary elsewhere.
보관

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
순도&문서
References
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SP-471P Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-471P2768011-36-3Dengue VirusFlavivirusVirus ProteaseDNA/RNA SynthesisDENVDengue virusRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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상품명:
SP-471P
Cat. No.:
HY-144645
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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