2. PROTAC Immunology/Inflammation
  3. Ligands for Target Protein for PROTAC STING
  4. STING-IN-2

STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research.

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CAS No. : 346691-38-1

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무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
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고객리뷰

Based on 10 publication(s) in Google Scholar

STING-IN-2 Related Antibodies

Top Publications Citing Use of Products

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17.  [Abstract]

    STING-IN-2 (1 μM; 24 h) significantly reduced the level of p-TBK1 in Lv-shAtg7 chondrocytes, a key kinase responsible for STING1 signal transduction.

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17.  [Abstract]

    Quantification of mRNA levels of Col2a1 and acan in the Lv-shAtg7 chondrocytes treated with STING-IN-2 (1 μM; 24 h).

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Aug 6:1-17.  [Abstract]

    STING-IN-2 (1 μM; 24 h) partially abolished the increased phosphorylation levels of MAPK14 (p-MAPK14) and MAP2K3/MKK3 (p-MAP2K3, a MAPK kinase responsible for MAPK14 activation) in Lv-shAtg7 chondrocytes.

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9.  [Abstract]

    STING-IN-2 (C-170) (4 mM; 2 h) largely abrogated the phosphorylation of PRPS1/2 T228 in the irradiated FHs 74 Int cells.

    STING-IN-2 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9.  [Abstract]

    STING-IN-2 (C-170) (4 mM; 2 h) abolished ionizing radiation-induced PRPS1/2 activity in FHs 74 Int cells.

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research[1].

    In Vitro

    THP-1 cells are pretreated with STING-IN-2 (C-170; 0.5 μM) and stimulated with cGAMP. STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    STING-IN-2 Related Antibodies
    분자량

    288.30

    화학식

    C15H16N2O4
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCC)C=C2
    선적

    Room temperature in continental US; may vary elsewhere.
    보관
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    용액&용해도
    In Vitro: 

    DMSO : 100 mg/mL (346.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4686 mL 17.3430 mL 34.6861 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    V1

    =
    Concentration (final)

    C2

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    Volume (final)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    순도&문서

    Purity: 99.71%

    SDS (393 KB)

    COA (245 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.4686 mL 17.3430 mL 34.6861 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 17.3430 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 8.6715 mL
    15 mM 0.2312 mL 1.1562 mL 2.3124 mL 5.7810 mL
    20 mM 0.1734 mL 0.8672 mL 1.7343 mL 4.3358 mL
    25 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4686 mL
    30 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8905 mL
    40 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1679 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.7343 mL
    60 mM 0.0578 mL 0.2891 mL 0.5781 mL 1.4453 mL
    80 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0839 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8672 mL
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    STING-IN-2 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    STING-IN-2346691-38-1Ligands for Target Protein for PROTACSTINGTarget Protein-binding MoietyStimulator of Interferon GenesTMEM173MITAERISMPYSpalmitoylationautoinflammatorycGAMPIFNB1p-TBK1TNFInhibitorinhibitorinhibit

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    상품명:
    STING-IN-2
    Cat. No.:
    HY-138682
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