Tetrazine-Amine monohydrochloride
Based on 2 publication(s) in Google Scholar
Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition. Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 1416711-59-5
- Formula: C9H10ClN5
- Molecular Weight:223.67
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tetrazine-Amine monohydrochloride
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Biological Activity
Click chemistry is used to describe the selective, modular, wide range and high-yield chemical reactions that allow rapid synthesis of new compounds through heteroatom linking (C-X-C). Bertozzi developed click chemistry in a new dimension —Bioorthogonal chemistry. It is defined as a rapid and selective reaction that does not interfere with biological processes under physiological conditions. Common reaction structures of click chemistry, such as Azide, Alkyne, DBCO, BCN, TCO and Tetrazine.?
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1416711-59-5
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Appearance Solid
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Molecular Weight 223.67
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Formula C9H10ClN5
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Color Purple to purplish red
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SMILES
NCC1=CC=C(C2=NN=CN=N2)C=C1.Cl
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Synonyms
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine (monohydrochloride); Tetrazine-NH2 monohydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : ≥ 100 mg/mL (447.09 mM)
DMSO : ≥ 50.5 mg/mL (225.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Devaraj NK, et, al. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6. [Content Brief]
[2]. Devaraj NK, et, al. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec;19(12):2297-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.4709 mL | 22.3547 mL | 44.7093 mL | 111.7733 mL |
| 5 mM | 0.8942 mL | 4.4709 mL | 8.9419 mL | 22.3547 mL | |
| 10 mM | 0.4471 mL | 2.2355 mL | 4.4709 mL | 11.1773 mL | |
| 15 mM | 0.2981 mL | 1.4903 mL | 2.9806 mL | 7.4516 mL | |
| 20 mM | 0.2235 mL | 1.1177 mL | 2.2355 mL | 5.5887 mL | |
| 25 mM | 0.1788 mL | 0.8942 mL | 1.7884 mL | 4.4709 mL | |
| 30 mM | 0.1490 mL | 0.7452 mL | 1.4903 mL | 3.7258 mL | |
| 40 mM | 0.1118 mL | 0.5589 mL | 1.1177 mL | 2.7943 mL | |
| 50 mM | 0.0894 mL | 0.4471 mL | 0.8942 mL | 2.2355 mL | |
| 60 mM | 0.0745 mL | 0.3726 mL | 0.7452 mL | 1.8629 mL | |
| 80 mM | 0.0559 mL | 0.2794 mL | 0.5589 mL | 1.3972 mL | |
| 100 mM | 0.0447 mL | 0.2235 mL | 0.4471 mL | 1.1177 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tetrazine-Amine monohydrochloride Related Classifications
HY-W053709A Related Classifications
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