2. PROTAC
  3. PROTAC Linkers
  4. Tetrazine-Ph-NHS ester

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Tetrazine-Ph-NHS ester Chemical Structure

Tetrazine-Ph-NHS ester Chemical Structure

CAS No. : 1616668-55-3

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10 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

Tetrazine-Ph-NHS ester Related Antibodies

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Description

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrazine-Ph-NHS ester Related Antibodies
Molecular Weight

313.27

Formula

C14H11N5O4
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=C(ON1C(CCC1=O)=O)CC2=CC=C(C3=NN=CN=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (319.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1921 mL 15.9607 mL 31.9213 mL
5 mM 0.6384 mL 3.1921 mL 6.3843 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1921 mL 15.9607 mL 31.9213 mL 79.8034 mL
5 mM 0.6384 mL 3.1921 mL 6.3843 mL 15.9607 mL
10 mM 0.3192 mL 1.5961 mL 3.1921 mL 7.9803 mL
15 mM 0.2128 mL 1.0640 mL 2.1281 mL 5.3202 mL
20 mM 0.1596 mL 0.7980 mL 1.5961 mL 3.9902 mL
25 mM 0.1277 mL 0.6384 mL 1.2769 mL 3.1921 mL
30 mM 0.1064 mL 0.5320 mL 1.0640 mL 2.6601 mL
40 mM 0.0798 mL 0.3990 mL 0.7980 mL 1.9951 mL
50 mM 0.0638 mL 0.3192 mL 0.6384 mL 1.5961 mL
60 mM 0.0532 mL 0.2660 mL 0.5320 mL 1.3301 mL
80 mM 0.0399 mL 0.1995 mL 0.3990 mL 0.9975 mL
100 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7980 mL
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Tetrazine-Ph-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrazine-Ph-NHS ester1616668-55-3PROTAC LinkersInhibitorinhibitorinhibit

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