Tetrazine-Ph-NHCO-C3-NHS ester
Based on 1 Customer Validation
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
For research use only. We do not sell to patients.
- Purity: 98.40%
- CAS No.: 1244040-64-9
- Formula: C18H18N6O5
- Molecular Weight:398.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1244040-64-9
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Appearance Solid
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Molecular Weight 398.37
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Formula C18H18N6O5
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Color Pink to red
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SMILES
O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC2=CC=C(C3=NN=CN=N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (251.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5102 mL | 12.5511 mL | 25.1023 mL | 62.7557 mL |
| 5 mM | 0.5020 mL | 2.5102 mL | 5.0205 mL | 12.5511 mL | |
| 10 mM | 0.2510 mL | 1.2551 mL | 2.5102 mL | 6.2756 mL | |
| 15 mM | 0.1673 mL | 0.8367 mL | 1.6735 mL | 4.1837 mL | |
| 20 mM | 0.1255 mL | 0.6276 mL | 1.2551 mL | 3.1378 mL | |
| 25 mM | 0.1004 mL | 0.5020 mL | 1.0041 mL | 2.5102 mL | |
| 30 mM | 0.0837 mL | 0.4184 mL | 0.8367 mL | 2.0919 mL | |
| 40 mM | 0.0628 mL | 0.3138 mL | 0.6276 mL | 1.5689 mL | |
| 50 mM | 0.0502 mL | 0.2510 mL | 0.5020 mL | 1.2551 mL | |
| 60 mM | 0.0418 mL | 0.2092 mL | 0.4184 mL | 1.0459 mL | |
| 80 mM | 0.0314 mL | 0.1569 mL | 0.3138 mL | 0.7844 mL | |
| 100 mM | 0.0251 mL | 0.1255 mL | 0.2510 mL | 0.6276 mL |
Tetrazine-Ph-NHCO-C3-NHS ester Related Classifications
HY-133479 Related Classifications
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