Tetrazine-Ph-NHCO-C3-NHS ester

Name: Tetrazine-Ph-NHCO-C3-NHS ester
Brand: MedChemExpress
SKU: HY-133479
Rating: 4.5 (1 reviews)

Cat. No.: HY-133479 Purity: 98.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Tetrazine-Ph-NHCO-C3-NHS ester Chemical Structure

CAS No. : 1244040-64-9

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

398.37

Formula

C₁₈H₁₈N₆O₅

CAS No.

1244040-64-9

Appearance

Solid

Color

Pink to red

SMILES

O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC2=CC=C(C3=NN=CN=N3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (251.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5102 mL	12.5511 mL	25.1023 mL
5 mM	0.5020 mL	2.5102 mL	5.0205 mL
10 mM	0.2510 mL	1.2551 mL	2.5102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (270 KB) SDS (392 KB)

COA (246 KB) HNMR (272 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5102 mL	12.5511 mL	25.1023 mL	62.7557 mL
	5 mM	0.5020 mL	2.5102 mL	5.0205 mL	12.5511 mL
	10 mM	0.2510 mL	1.2551 mL	2.5102 mL	6.2756 mL
	15 mM	0.1673 mL	0.8367 mL	1.6735 mL	4.1837 mL
	20 mM	0.1255 mL	0.6276 mL	1.2551 mL	3.1378 mL
	25 mM	0.1004 mL	0.5020 mL	1.0041 mL	2.5102 mL
	30 mM	0.0837 mL	0.4184 mL	0.8367 mL	2.0919 mL
	40 mM	0.0628 mL	0.3138 mL	0.6276 mL	1.5689 mL
	50 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2551 mL
	60 mM	0.0418 mL	0.2092 mL	0.4184 mL	1.0459 mL
	80 mM	0.0314 mL	0.1569 mL	0.3138 mL	0.7844 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6276 mL