Thymine 1-β-D-arabinofuranoside

Cat. No.: HY-137848 Pureza: 98.0%: Ficha de datos
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Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

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Thymine 1-β-D-arabinofuranoside Estructura química

No. CAS : 605-23-2

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	>1 mM Compound: 6	Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay	[PMID: 2033590]
HL-60	IC₅₀	>1 mM Compound: 6	Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay	[PMID: 2033590]
KB	IC₅₀	>500 μg/mL Compound: ara-T	In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells	[PMID: 2838633]
KB	IC₅₀	0.6 μg/mL Compound: ara-T	Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells	[PMID: 2838633]
OST	IC₅₀	0.0062 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK Cytotoxicity against human OST TK- cells expressing HSV1 TK	[PMID: 17181158]
OST	IC₅₀	0.055 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.1 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.12 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.15 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.24 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.37 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]

Peso molecular

258.23

Fòrmula

C₁₀H₁₄N₂O₆

No. CAS

605-23-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@H]1[C@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pureza y Documentación

Purity: 98.0%

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Ficha de datos (269 KB) SDS (393 KB)

COA (253 KB) HNMR (134 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]