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Cat. No.: HY-169628

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Topoisomerase I/II inhibitor 7

Name: Topoisomerase I/II inhibitor 7
Brand: MedChemExpress
SKU: HY-169628
Price: 332.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor.

For research use only. We do not sell to patients.

CAS No.: 489413-54-9
Formula: C₁₈H₁₃ClN₂O₃
Molecular Weight:340.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Topoisomerase I/II inhibitor 7 Chemical Structure

CAS No.: 489413-54-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor^[1].

IC₅₀ & Target

^[1]

Topoisomerase I

Topoisomerase II

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	>50 μM Compound: 5h	Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay	[PMID: 26988802]
HCT-15	IC₅₀	>50 μM Compound: 5h	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 26988802]
T47D	IC₅₀	>50 μM Compound: 5h	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 26988802]

Chemical Information

CAS No. 489413-54-9
Molecular Weight 340.76
Formula C₁₈H₁₃ClN₂O₃
SMILES

O=C(N1N=C(CC1C2=CC=CO2)C3=CC=C(Cl)C=C3)C4=CC=CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmad P, et al. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor[J]. Bioorganic & Medicinal Chemistry, 2016, 24(8): 1898-1908. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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