2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 8

Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells.

For research use only. We do not sell to patients.

Topoisomerase I inhibitor 8 Chemical Structure

Topoisomerase I inhibitor 8 Chemical Structure

CAS No. : 210346-40-0

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Topoisomerase I inhibitor 8 Related Antibodies

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Description

Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].

IC50 & Target

Topoisomerase I

 

In Vitro

Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1].
Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 8 Related Antibodies
Molecular Weight

420.43

Formula

C24H21FN2O4
CAS No.
SMILES

CC1=C(F)C=C2C3=C1CCCC3=C4C(C(N5C4)=CC([C@](CC)(O)C(OC6)=O)=C6C5=O)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase I inhibitor 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 8210346-40-0Topoisomerase I inhibitor8Topoisomerase I inhibitor-8Topoisomerasecamptothecinhexacyclic analogueantitumor activity,Inhibitionketonespeptides and proteinstoxicityInhibitorinhibitorinhibit

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