Topoisomerase I inhibitor 8
Based on 1 Customer Validation
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 210346-40-0
- Formula: C24H21FN2O4
- Molecular Weight:420.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
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Topoisomerase I |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HOC-21 cell line | IC50 |
2.06 ng/mL
Compound: 57
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In vitro antitumor activity against HOC-21 (human ovarian cancer) cells.
In vitro antitumor activity against HOC-21 (human ovarian cancer) cells.
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[PMID: 9632364] |
| P388 | IC50 |
0.22 ng/mL
Compound: 57
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In vitro antitumor activity against P388 (murine leukemia) cells.
In vitro antitumor activity against P388 (murine leukemia) cells.
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[PMID: 9632364] |
| QG-56 | IC50 |
0.17 ng/mL
Compound: 57
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In vitro antitumor activity against QG-56 (human lung cancer) cells.
In vitro antitumor activity against QG-56 (human lung cancer) cells.
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[PMID: 9632364] |
Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1].
Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 210346-40-0
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Appearance Solid
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Molecular Weight 420.43
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Formula C24H21FN2O4
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Color Light yellow to brown
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SMILES
CC1=C(F)C=C2C3=C1CCCC3=C4C(C(N5C4)=CC([C@](CC)(O)C(OC6)=O)=C6C5=O)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (118.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3785 mL | 11.8926 mL | 23.7852 mL | 59.4629 mL |
| 5 mM | 0.4757 mL | 2.3785 mL | 4.7570 mL | 11.8926 mL | |
| 10 mM | 0.2379 mL | 1.1893 mL | 2.3785 mL | 5.9463 mL | |
| 15 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 20 mM | 0.1189 mL | 0.5946 mL | 1.1893 mL | 2.9731 mL | |
| 25 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3785 mL | |
| 30 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL | |
| 40 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4866 mL | |
| 50 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1893 mL | |
| 60 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL | |
| 80 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL | |
| 100 mM | 0.0238 mL | 0.1189 mL | 0.2379 mL | 0.5946 mL |
Topoisomerase I inhibitor 8 Related Classifications
HY-148058 Related Classifications
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