Topoisomerase IIα-IN-7
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability.
For research use only. We do not sell to patients.
- Formula: C25H27Cl3N4O3
- Molecular Weight:537.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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topoisomerase II alpha 7.7 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
2.1 μM
Compound: 53b
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Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 36689894] |
| HepG2 | IC50 |
0.13 μM
Compound: 53b
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 36689894] |
| K562 | IC50 |
0.19 μM
Compound: 53b
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Cytotoxicity against human K562 cells assessed as reduction in cell viability at 10 uM by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability at 10 uM by MTT assay
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[PMID: 36689894] |
| MCF7 | IC50 |
0.15 μM
Compound: 53b
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 36689894] |
Topoisomerase IIα-IN-7 (Compound 53b) has cytotoxicity to MCF-7 cancer cell line, HepG2 cancer cell line and human embryonic kidney derived HEK293 cells with IC50 values of 0.15 µM, 0.13 µM and 2.1 µM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 537.87
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Formula C25H27Cl3N4O3
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SMILES
O=C(NC1=C(OCC2=CC(C(NC3CCCNC3)=O)=CC=C2)C=CC=C1)C4=C(Cl)C(Cl)=C(C)N4.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase IIα-IN-7 Related Classifications
HY-152479 Related Classifications
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