A-889425
A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freund's adjuvant (HY-153808)-inflamed rat hind paws.
For research use only. We do not sell to patients.
- CAS No.: 1072921-02-8
- Formula: C19H18F3N3O3S
- Molecular Weight:425.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1072921-02-8
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Molecular Weight 425.42
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Formula C19H18F3N3O3S
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SMILES
O=C(C1=CCN(C2=NC=CC=C2C)CC1)NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. McGaraughty S, et al. Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats. J Neurophysiol. 2008;100(6):3158-3166. [Content Brief]
[2]. Brederson JD, et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse. 2012;66(3):187-195. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-889425 Related Classifications
HY-133166 Related Classifications
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